Febbre puerperale

What is puerperal pyrexia?¹

Puerperal (postpartum) is defined as the presence of a fever, which is greater than or equal to 38°C, in a woman within six weeks of her having given birth. Pyrexia complicates 5% of pregnancies, with an infective cause identified in about 50% of cases.

Sepsi occurs when an infective cause results in multi-organ dysfunction. The most common site of sepsis is the genital tract. It is also important to consider indirect sepsis (eg, influenza, pneumonia) and non-infective causes amongst the differential diagnosis.

Causes of puerperal pyrexia (aetiology)

Specific causes of puerperal pyrexia may include:

• Infezione del tratto urinario:

  • Frequency, dysuria, haematuria.

  • Rigors from pielonefrite.

  • 95% caused by Escherichia coli, Proteus spp. and Klebsiella spp.

• Genital tract infection:

  • Tender bulky uterus.

  • Prolonged bleeding/pink or discoloured lochia.

  • Painful inflamed perineum.

  • May be caused by E. coli, other anaerobes, Group A streptococcus (GAS) (also known as Streptococcus pyogenes), Staphylococcus spp. and Clostridium welchii (rare, but serious).

• Mastite:

  • Sintomi simili all'influenza.

  • Painful, hard, red breast with possible abscess.

  • Nipple trauma and cellulitis.

  • Usually caused by Staphylococcus spp.

• Endometrite: see link for separate article but symptoms include:

  • Febbre.

  • Dolore addominale inferiore.

  • Smelly vaginal discharge.

  • Increased vaginal bleeding.

  • Disuria.

• Deep venous thrombosis:²
  

  • A low-grade pyrexia can be caused by tromboembolismo venoso.

  • Caused by venous stasis and hypercoagulability.

  • Painful, swollen calf.

  • Ovarian vein thrombophlebitis is a rare cause of persistent puerperal pyrexia.³

• Altre infezioni:

  • Pyrexia in a recently delivered mother may also be due to causes common to all, such as viral infection or chest infection.

  • Febbre ghiandolare may be a common cause of fever in the postpartum period.⁴

Symptoms of puerperal pyrexia (presentation)

The symptoms with which the mother presents may well provide some idea of the source of the infection or there may be many symptoms referring to more than one system, which will require a systematic method of determining the problem.

Storia

A full history should be taken, to include a full history of the delivery - establish:

• When the membranes ruptured.

• The length of labour.

• The instrumentation used.

• Sutures required.

• Whether the placenta was complete.

• Whether there was any bleeding during or after delivery.

Esame

• Take the patient's temperature and blood pressure.

• Palpate the uterus to assess size and tenderness.

• Assess any perineal wounds and lochia.

• Examine the breasts.

• Examine the chest for signs of infection.

• Examine the abdomen.

• Examine the legs for possible thromboses.

Indagini

• High vaginal swab.

• Urine culture and microscopy.

• Other swabs as felt necessary - eg, wound swabs, throat swabs.

• FBC.

• Blood culture x 2.

• Ultrasound scan may be required to assist diagnosis of retained products of conception.

• Sputum culture if indicated.

Management of puerperal pyrexia

Misure generali

Ice packs may be helpful for pain from perineal wounds or mastitis.

Rest and adequate fluid intake are required, particularly for mothers who are breastfeeding.

The following signs and symptoms should prompt urgent referral for hospital assessment and, if the woman appears seriously unwell, by emergency ambulance¹:

• Pyrexia (greater than or equal to 38°C).

• Sustained tachycardia (≥90 beats/minute).

• Breathlessness (respiratory rate ≥20 breaths/minute).

• Dolore addominale o toracico.

• Diarrhoea and/or vomiting - may be due to endotoxins.

• Dolore e sensibilità all'angolo uterino o renale.

• The woman is generally unwell or seems unduly anxious or distressed.

Prophylaxis should be considered for close family members if either Group A streptococcal (GAS) or meningococcus (Neisseria meningitidis) infection is suspected.

Farmacologico

Administration of intravenous broad-spectrum antibiotics within one hour of suspicion of severe sepsis, with or without septic shock, is recommended:¹

• Analgesia may be required. NB: non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided for pain relief in cases of sepsis, as they impede the ability of polymorphs to fight GAS infection.

• Antibiotics should be commenced after taking specimens and should not be delayed until the results are available.

• A combination of either piperacillin/tazobactam or a carbapenem plus clindamycin provides one of the broadest ranges of treatment for severe sepsis.

• Meticillin-resistant Staphylococcus aureus (MRSA) may be resistant to clindamycin; hence, if the woman is, or is highly likely to be, MRSA-positive, vancomycin or teicoplanin may be added until sensitivity is known.

• Allattamento al seno limits the use of some antimicrobials; hence, the advice of a consultant microbiologist should be sought at an early stage.

• Intravenous immunoglobulin (IVIg) is recommended for severe invasive streptococcal or staphylococcal infection if other therapies have failed. It has an immunomodulatory effect and, in staphylococcal and streptococcal sepsis, it also neutralises the super-antigen effect of exotoxins. It also inhibits production of tumour necrosis factor and interleukins.

• If the fever is prolonged then treatment with heparin should also be considered.

Chirurgico

Surgical intervention may be required if it is thought that an abscess has formed, as in this case the fever will not settle until the abscess has been incised and drained.

Complications of puerperal pyrexia

The possible complications of the infection will depend on the site, although several complications such as setticemia, embolo polmonare, coagulazione intravascolare disseminata e polmonite are common to all. Sepsis with acute organ dysfunction has a mortality rate of 20-40%, rising to around 60% if septicaemic shock develops.⁵

• Genital tract infection may lead to abscess formation, adhesions, peritonitis, haemorrhage and subsequent infertility if not treated early and aggressively.

• Urinary tract infection may progress to pyelonephritis and renal scarring if left untreated.

• Mastitis may lead to the formation of breast abscesses if treatment is not started early.

Prognosi

The majority of patients will make a full recovery with no lasting effects if treated speedily with appropriate antibiotic therapy and fluids.

However, the possibility of sepsis and lasting sequelae or even death mean it is important to treat all cases of puerperal pyrexia early and aggressively.

Preventing puerperal pyrexia

• Scrupulous attention to hygiene should be used during all examinations and use of instrumentation during and after labour.

• Any GAS identified during pregnancy should be treated aggressively.

• Some centres advocate the use of prophylactic antibiotics during prolonged labour.

• Catheterisation should be avoided where possible.

• Perineal wounds should be cleaned and sutured as soon as possible after delivery.

• All blood losses and the completeness of the placenta should be recorded at all deliveries.

• Early mobilisation of delivered mothers will help to protect against venous thrombosis.

• New mothers should be helped to acquire the skills required for successful breastfeeding in order to reduce the risk of mastitis.⁶

Postoperative infection following caesarean section

• Lower segment caesarean section (LSCS) is the most important risk factor for puerperal pyrexia; there is a significantly increased risk of postpartum sepsis, wound problems, urinary tract infections and fever following LSCS.

• In the UK there is an 8% risk of infection following LSCS - appropriate antibiotic prophylaxis before skin incision should be offered routinely. Choose antibiotics that are effective against endometritis, urinary tract and wound infections, but avoid co-amoxiclav.⁷

• Compared with placebo or no treatment, the use of prophylactic antibiotics in women undergoing caesarean section reduced the incidence of wound infection, endometritis and serious infectious complications by 60-70%.⁸