Eczema on hands and feet

Che cos'è l'eczema?

Eczema is a very nonspecific term. It is often used synonymously with dermatitis which simply means inflammation of skin. The different appearance, descriptions and distribution on the hands and feet can be confusing but they do give clues about aetiology.

For further information, see the separate Contact and occupational dermatitis articolo.

Acute pompholyx (dyshidrotic) eczema¹

• On the palms or soles it often starts as tiny vesicles deep under the skin, described as like 'sago'. If severe, the vesicles may coalesce to form tense bullae. In time, these burst to release exudate to the surface, with subsequent formation of erosions. Eventually, crusting occurs followed by healing or new lesions breaking out.

• Severe pompholyx around the nail folds may cause nail dystrophy, resulting in irregular ridges and chronic paronychia.

Subacute eczema on palms and soles

• This presents as erosions, crusting and some exudate; however, often the vesicles are not seen.

Chronic eczema on palms and soles

• This results in excessive scaling or keratinisation.

• Thick keratin or scale forms, which prevents easy movement of the hands and fingers, resulting in painful fissures.

Dorsum of hands or feet

• Acute or subacute eczema presents as weeping, erosions and crusting.

• Chronic eczema is dry, scaling and may show chapping with shallow erosions if contact with irritants has occurred.

Eczema on the hands and feet may be classified as endogenous or exogenous, although the aetiology may be mixed.

Exogenous eczema

Contact irritant dermatitis may result from any weak acid or alkali, including detergents, shampoos and cleaning materials. It may result from foodstuffs, oils and greases. These may affect the dorsum of the hand first; however, prolonged use over months or years leads to involvement of the palms. Chronic hand eczema (CHE) is commonly seen in adults and often in the context of occupational exposures, but occurrences in children should prompt a detailed history of leisure-time and school activities where exposures can occur.³

Contact allergy is due to a type IV hypersensitivity reaction and may be precipitated by such substances as formaldehyde, rubber compounds and preservative in creams or cutting oils. The eczema should only occur at the site of contact, for instance this will be the soles from rubber in shoes but all over the hands from creams.

Endogenous eczema

Endogenous eczema occurs when internal factors that are usually unknown precipitate the eczema. Pompholyx eczema is usually endogenous but is more common in hot climates. Atopic individuals are susceptible to hand eczema, especially if exposed to irritants.

• Irrespective of the cause, continued contact with irritant substances will make any hand or foot eczema worse. This may mean taking time off work for engineers, cooks, hairdressers and others. Sometimes a change of employment has to be considered.

• Treat blisters, exudate or erosions by soaking the affected part in potassium permanganate solution four-hourly until it is dry. Potassium permanganate is available as crystals or in a 1:1,000 solution. The strong solution is purple in colour but a few drops should be put into a basin to produce a light pink colour. If the solution is too strong, brown staining will occur.

• Apply a potent steroid cream or ointment twice a day to gain control of the condition. The evidence for long-term maintenance therapy is limited and there is a risk of scarring due to inhibition of the repair system of the stratum corneum. Treatment should therefore be limited to six weeks unless necessary. A potent form is required for such tough skin, especially the palms and soles. No steroid cream will suppress the eczema if the causative agent is not removed.

• Steroid creams may be applied under occlusion. There is some doubt as to whether the usual twice-daily application of steroid creams is superior to just once-daily application.⁶ The latter may be more convenient and cheaper.

• Topical pimecrolimus and tacrolimus are licensed for the treatment of atopic eczema not controlled by maximal topical corticosteroid treatment or where corticosteroid side-effects have occurred (especially skin atrophy).

• Topical pimecrolimus is recommended for moderate atopic eczema on the face and neck of children aged 2-16 years. Topical tacrolimus can be used for moderate-to-severe atopic eczema in adults and in children aged over 2 years. They are normally prescribed under supervision from a dermatologist.^{7 8}

• Hyperkeratotic plaques can be treated with emollients containing urea (under cotton gloves at night for the hands and socks for the feet if needed), or Diprosalic ® ointment OD-BD is often effective for erythema with scale. Very thick scale on the feet can be treated by higher strengths of urea (eg, Flexitol 25% ® Urea Heel Balm; various 20% urea products can be purchased online) should be applied to the skin under a damp sock with a dry sock on top, starting 3 nights a week.⁹

  • In Secondary Care 10-20% preparations of salicylic acid in yellow soft paraffin can be used, however, these are often made up as a 'special' and can be costly.

• Avoid soap and detergents, and wash hands using a moisturiser such as aqueous cream or emulsifying ointment. Regularly apply a moisturiser for dry skin between steroid applications. Protect hands when doing wet work, with rubber or PVC gloves, or use cotton gloves for dry work.

• Oral alitretinoin, a retinoid, is licensed for the treatment of chronic refractory hand eczema. It is contra-indicated in uncontrolled hyperlipidaemia, uncontrolled hypothyroidism and hypervitaminosis A.¹⁰

• Systemic corticosteroids have been used in short courses for refractory eczema. Likewise, ciclosporin is occasionally used off-label for refractory hand eczema if first-line and second-line treatment have failed.

• Phototherapy with ultraviolet B (UVB) or psoralen with ultraviolet A (PUVA) can be used in refractory cases of hand eczema, although prolonged use should be avoided, as this increases the risk of skin cancer.

A Cochrane review of interventions for hand eczema found:¹¹

• Topical corticosteroids and UV phototherapy were two of the major standard treatments, but evidence is insufficient to support one specific treatment over another.

• The effect of topical calcineurin inhibitors (for example, pimecrolimus, tacrolimus) is not certain.

• Alitretinoin is more effective than placebo in controlling symptoms, but advantages over other treatments need evaluating.

Most findings were from single studies with low precision, so should be interpreted with caution.

If the offending irritant can be avoided then gradual improvement may occur over about six months but some will still have troublesome eczema. If exposure persists then symptoms will continue and the overall quality of life may be poor.¹² Cement dermatitis is due to the chromium content and it produces a very nasty dermatitis that often continues even after stopping exposure.

Most children will outgrow eczema, and their symptoms will be resolved by adulthood. However, children with later onset, or more severe disease may have increased persistence.¹³

• Refer urgently to dermatology if eczema is severe and has not responded to optimum topical treatment after 1 week.

• Refer for a routine dermatology appointment if the diagnosis is, or has become, uncertain; current management has not controlled eczema satisfactorily (for example, the person is having one to two flares per month), or the person is reacting adversely to many emollients; treatment (application) advice is needed (for example, bandaging techniques); contact allergic dermatitis is suspected and allergen testing is required; there is recurrent secondary infection.

Most patients with eczema on the hands and feet should be patch tested to establish a cause. Diagnosis of irritant and contact dermatitis on clinical grounds alone is unreliable.