Iniezione a lunga durata di Paliperidone
Xeplion, Trevicta, Byannli
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 17 Ago 2024
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Paliperidone long-acting injection will be given to you by your doctor or nurse every four weeks to begin with.
If you miss an appointment for an injection, please make another appointment as soon as possible.
The most common side-effects are headache and difficulties sleeping.
A colpo d'occhio
Paliperidone is an antipsychotic medicine given as a long-acting injection.
It is used for adults with schizophrenia to help regulate brain chemicals and control symptoms.
Injections are given regularly, typically once a month, with 3-monthly and 6-monthly options available.
Benefits include not having to remember to take daily tablets.
Keep all regular appointments for your injections and monitoring.
Tell your doctor if you are pregnant, have a heart condition, or other specified health issues.
Do not drink alcohol while on paliperidone as it increases the risk of side-effects.
About paliperidone long-acting injection
Tipo di medicinale | Un medicinale antipsicotico |
Utilizzato per | Schizophrenia in adults |
Chiamato anche | Xeplion®; Trevicta®; Byannli® |
Disponibile come | Long-acting intramuscular depot injection |
Schizofrenia is a mental health condition that causes disordered ideas, beliefs and experiences. You will have been prescribed paliperidone to relieve the symptoms of schizophrenia. Such symptoms include hearing, seeing, or sensing things that are not real, having mistaken beliefs and feeling unusually suspicious. Paliperidone works on the balance of chemical substances in your brain to help control these types of symptoms.
Long-acting or 'depot' injections are used for maintenance once your symptoms have been eased by taking tablets. The injection slowly releases paliperidone into your body. You will need to receive the injection regularly, once every month. A three-monthly injection (Trevicta®) is available for people who are stable on once-monthly injections. There is also a six-monthly injection (Byannli®). The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having paliperidone injection
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having paliperidone injections, it is important that your doctor knows:
Se sei incinta o stai allattando.
Se hai una malattia cardiaca o dei vasi sanguigni.
Se hai problemi al fegato, ai reni o alla prostata.
Se hai problemi con la respirazione.
If you have any of the following: epilepsy, depressione, Malattia di Parkinson, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called miastenia grave.
If you have ever had yellowing of your skin or the whites of your eyes (ittero) or a blood disorder.
If you are scheduled to have chirurgia della cataratta.
If you have a tumour on your adrenal gland (a condition called phaeochromocytoma), or if you have been told you have 'a prolactin-dependent tumour'.
Se hai avuto una reazione allergica a un medicinale.
Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
How paliperidone long-acting injection is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paliperidone and it will also provide you with a full list of the side-effects which you may experience from having it.
Paliperidone injection will be given to you by your doctor or nurse. The first two doses will be injected into a muscle in your upper arm. After this, the injections can either be given into a muscle in your arm, or if preferred, the buttocks.
If you haven't received paliperidone injection before, you will initially be given a dose of 150 mg and then a dose of 100 mg a week later. From then on, you will need to have one injection each month. Your doctor will adjust the amount of paliperidone given to suit what is right for you.
When your dose of once-monthly injection is stabilised, a three-monthly injection is available and may be suitable for you.
Ottenere il massimo dal tuo trattamento
Your treatment will require careful monitoring to make sure that you get the best possible benefit from paliperidone. Keep your regular doctor's appointments so that you get your injections on time and your progress can be checked. If you miss an appointment for an injection, contact your doctor to arrange for another appointment as soon as possible. This is so that you can be given the injection without any further delay.
If you are due to have any dental treatment or an operation, please tell the person carrying out the treatment that you have had a paliperidone injection. This is important because it may interfere with any anaesthetic you receive. If you are having cataract surgery, it is particularly important that you tell your surgeon that you are on paliperidone. This is because an eye problem known as 'floppy iris syndrome' has developed in some people and your doctor will want to advise you about the risks of this.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with paliperidone.
If you have diabetes you may need to check your blood glucose more frequently, as paliperidone may affect the levels of sugar in your blood. Your doctor will advise you about this.
If you drink alcohol, please ask your doctor for advice. Alcohol increases the risk of side-effects from paliperidone, so it is best avoided.
Can paliperidone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with paliperidone long-acting injection. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common paliperidone injection side-effects (these affect more than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Difficulties sleeping | Discuss this with your doctor if it becomes troublesome |
Mal di testa | Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico |
Common paliperidone injection side-effects (these affect fewer than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Pain at the site of the injection | This should quickly pass. If the area becomes red, swollen or 'lumpy', let your doctor know |
Feeling dizzy, tired or sleepy | Non guidare e non utilizzare strumenti o macchinari. Non bere alcolici |
Sensazione di tremore o irrequietezza, movimenti insoliti o incontrollabili | Speak with your doctor |
Feeling sick (nausea) or being sick (vomiting), indigestion, tummy (abdominal) discomfort | Attieniti a pasti semplici - evita cibi ricchi o piccanti |
Diarrea | Bevi molta acqua per reintegrare i liquidi persi |
Costipazione | Bevi molta acqua e segui una dieta equilibrata |
Increased infections, weight increase or loss, mood changes, high blood pressure, toothache, rash, aches and pains | Discuti questi con il tuo medico se qualcuno diventa problematico |
Changes to the results of some medical tests | Il tuo medico controllerà questi |
Importante: if you experience symptoms such as muscle stiffness, a very high temperature (fever), feeling confused, a fast heartbeat and sweating, you should contact your doctor immediately. These can be signs of a rare but serious condition known as neuroleptic malignant syndrome.
If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice.
How to store paliperidone
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
If you suspect that you have had an overdose of this medicine, contact your doctor or go to the accident and emergency department of your local hospital.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Sito web Yellow Card.

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Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.
Domande frequenti
What should I do if I miss an appointment for my paliperidone injection?
It is important to contact your doctor as soon as possible to reschedule your appointment if you miss one. This ensures you receive your injection without further delay, which is crucial for the effectiveness of the treatment.
Are there any specific concerns if I have diabetes and am taking paliperidone?
Yes, if you have diabetes, you might need to check your blood glucose levels more often. Paliperidone can affect your blood sugar, so your doctor will provide specific advice on how to manage this while on the medication.
Can I take other medications, including over-the-counter or herbal remedies, while on paliperidone?
Before taking any other medicines, including those available without a prescription, or any herbal and complementary medicines, you should check with a pharmacist to ensure they are suitable to take with paliperidone. Some medications can interact negatively.
What is 'floppy iris syndrome' and why is it important to tell my surgeon about paliperidone before cataract surgery?
'Floppy iris syndrome' is an eye problem that has been observed in some people taking paliperidone. If you are having cataract surgery, it is particularly important to inform your surgeon about your medication so they can advise you on the potential risks and take necessary precautions during the procedure.
What should I do if I think I'm experiencing Neuroleptic Malignant Syndrome?
If you experience symptoms like muscle stiffness, a very high temperature (fever), confusion, a fast heartbeat, and sweating, you should contact your doctor immediately. These could be signs of a rare but serious condition called neuroleptic malignant syndrome.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Xeplion® prolonged-release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Manufacturer's PIL, Trevicta® 175 mg prolonged release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Next review due: 24 Aug 2027
17 Ago 2024 | Ultima versione

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