Nitrofurantoina per le infezioni urinarie
Macrobid
Revisione paritaria di Dr Colin Tidy, MRCGPUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 5 Apr 2025
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Take nitrofurantoin with (or just after) a meal or a snack. This will help your body to absorb the medicine and help to prevent stomach upset.
Space out your doses evenly throughout the day, and remember to finish the course prescribed.
Nitrofurantoin can darken the colour of your urine. This is nothing to worry about.
Contact your doctor if you develop a cough with difficulty breathing and pains in your chest during treatment with nitrofurantoin.
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About nitrofurantoin
Tipo di medicinale | An antibacterial |
Utilizzato per | Urinary tract infection (UTI) in adults and in children over 3 months of age |
Chiamato anche | Macrobid® |
Disponibile come | Tablets, capsules, prolonged-release capsules, oral liquid medicine |
What is nitrofurantoin used for?
Torna ai contenutiNitrofurantoin is a type of antibiotico used to treat urinary tract infections (UTIs) in adults and children over 3 months.
Most UTIs are caused by germs (bacteria) that come from your own bowel. They are usually easily treated with a short course of an antibacterial medicine such as nitrofurantoin.
Occasionally, longer-term treatment is needed to prevent infections from coming back. Nitrofurantoin works by killing the bacteria causing the infection.
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Side effects of nitrofurantoin
Torna ai contenutiCommon side effects of nitrofurantoin are:
Sensazione di nausea.
Vomito.
Perdita di appetito.
Sensazione di vertigini o sonnolenza.
Eruzione cutanea pruriginosa.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
Gli effetti indesiderati spesso migliorano man mano che il tuo corpo si adatta al nuovo medicinale, ma parla con il tuo medico o farmacista se uno dei seguenti persiste o diventa problematico.
How to manage nitrofurantoin side effects
Torna ai contenutiNitrofurantoin side effects | Cosa posso fare se sperimento questo? |
Sensazione di malessere (nausea) o vomito, perdita di appetito | Stick to simple foods - avoid fatty or spicy meals. Remember to take nitrofurantoin with food |
Diarrea | Bevi molta acqua per reintegrare i liquidi persi |
Sensazione di vertigini o sonnolenza | Non guidare e non utilizzare strumenti o macchinari mentre sei sotto effetto |
Itchy rash, allergic-type reactions, swollen salivary glands | Speak with your doctor or a pharmacist for further advice |
Importante: your doctor will have discussed with you the possibility of a less common side effect that may affect your lungs. You should let your doctor know straightaway if you experience any of the following:
Any difficulty breathing, pains in your chest, coughing, chills, or a high temperature (fever).
Se si verificano altri sintomi che ritieni possano essere dovuti al medicinale, parla con il tuo medico o farmacista per ulteriori consigli.
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Who should not take nitrofurantoin
Torna ai contenutiSome medicines aren’t suitable for certain health conditions or may require extra care. Before taking nitrofurantoin, it is important to let your doctor know:
If you are pregnant or breastfeeding. Although nitrofurantoin can be taken during pregnancy, it is still important that you tell your doctor about being pregnant.
Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.
Se hai il diabete (diabete mellito).
If you have been told you have anaemia, or if you have low levels of vitamin B or folic acid.
Se hai problemi respiratori.
If you have a problem where your nerves cause pain or numbness, called peripheral neuropathy.
If you have been told you have one of the following rare inherited conditions: porphyria or glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
How to take nitrofurantoin
Torna ai contenutiRead the information leaflet in the pack before starting. It explains nitrofurantoin and its possible side effects.
Take nitrofurantoin exactly as your doctor instructs. Your dose depends on whether it’s for treating or preventing an infection. Follow the label instructions.
Take each dose with food or a snack. Space doses evenly: four times a day = every 6 hours, twice a day = every 12 hours, once a day = every 24 hours.
Finish the full course, even if you feel well, to prevent the infection from returning. Most courses last 3-7 days; for frequent urine infections, treatment may last up to six months.
If you forget a dose, take it as soon as you remember. Do not take two doses at once to make up for a missed one.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiMost people feel better within a few days. If your symptoms don’t improve, see your doctor as you may need a different antibiotic.
Nitrofurantoin can turn your urine yellow or brown. This is harmless.
Check with a pharmacist before taking any other medicines. Some antacids can stop nitrofurantoin from working properly.
If you take the contraceptive pill, its effectiveness may be reduced if you have vomiting or diarrhoea lasting more than 24 hours. Ask your doctor or pharmacist about extra precautions.
Tell your doctor or dentist that you are taking nitrofurantoin before any treatment, as it can affect some tests.
Nitrofurantoin can stop the oral vaccino orale contro il tifo from working. Inform your healthcare provider if you are due for any vaccinations.
How to store nitrofurantoin
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
The liquid medicine lasts for 30 days after first opening.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati immediatamente al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Yellow Card website.
Domande frequenti
Torna ai contenutiHow long does it take for nitrofurantoin take to work on a UTI?
Most people start to feel better within 2-3 days of taking nitrofurantoin for a UTI. Burning and urgency often improve first, while bladder pressure or discomfort may take a bit longer. Always finish the full course, even if you feel better.
Is nitrofurantoin safe to take during pregnancy?
Nitrofurantoin is generally considered safe to take during pregnancy, especially in the 2nd and 3rd trimesters. However, it’s usually avoided close to delivery (around weeks 38-42) as it may affect the baby’s red blood cells.
Can you drink alcohol on nitrofurantoin?
Yes, you can drink alcohol in moderation while taking nitrofurantoin as alcohol does not interfere with how it works. However, drinking too much can make side effects such as nausea, dizziness, or stomach upset feel worse.
What should you avoid while taking nitrofurantoin?
When taking nitrofurantoin, you should avoid taking antacids containing magnesium trisilicate as they can reduce how well the medicine works.
Does nitrofurantoin make you urinate more?
No, nitrofurantoin does not make you urinate more. If you feel like you’re peeing more often, it is usually because of the UTI itself, not the medication.
Does nitrofurantoin contain penicillin?
No, nitrofurantoin does not contain penicillin. It is a different type of antibiotic used mainly to treat urinary tract infections and works differently from penicillin.

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Ulteriori letture e riferimenti
- Manufacturer's PIL; Nitrofurantoin 100 mg Prolonged-Release Capsules, ADVANZ Pharma (formerly Amdipharm Mercury Company Limited), The electronic Medicines Compendium. Dated December 2023
- Manufacturer's PIL, Nitrofurantoin 50 mg and 100 mg Capsules; ADVANZ Pharma (formerly Amdipharm Mercury Group Limited), The electronic Medicines Compendium. Dated January 2024.
- Manufacturer's PIL, Nitrofurantoin 25 mg/5 ml Oral Suspension; ADVANZ Pharma, The electronic Medicines Compendium. Dated January 2024.
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Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 5 Apr 2028
5 Apr 2025 | Ultima versione

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