Rigurgito mitralico
Revisione paritaria di Dr Colin Tidy, MRCGPUltimo aggiornamento di Dr Hayley Willacy, FRCGP Ultimo aggiornamento 23 Ott 2023
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In questa serie:Malattia delle valvole cardiacheStenosi mitralicaStenosi aorticaRigurgito aorticoEndocardite infettiva
The mitral valve is a valvola cardiaca that lies between the left atrium and left ventricle.
A colpo d'occhio
Mitral regurgitation is a condition where the mitral valve in your heart does not close properly.
This causes blood to leak back into the left atrium when the heart pumps.
Mild mitral regurgitation often causes no symptoms.
More severe cases can cause shortness of breath, tiredness, and swollen ankles.
Medicines can help manage symptoms but cannot fix the valve.
Surgery to repair or replace the valve may be needed for more severe cases.
Treatment can greatly improve the outlook for people with the condition.
The heart - mitral valve incompetence

What is mitral regurgitation?
Mitral regurgitation is sometimes called mitral insufficiency or mitral incompetence. In mitral regurgitation the valve does not close properly. This causes blood to leak back (regurgitate) into the left atrium when the left ventricle squeezes (contracts). Basically, the more open the valve remains, the more blood regurgitates and the more severe the problem.
Prolasso della valvola mitrale
This is also called floppy mitral valve. In this condition the valve is slightly deformed and bulges back into the left atrium when the ventricle contracts. This can let a small amount of blood leak back into the left atrium.
As many as 1 in 10 people have some degree of mitral valve prolapse. It becomes common with increasing age. It usually causes no symptoms, as the amount of blood that leaks back is often slight.
What causes mitral regurgitation?
Sometimes regurgitation is rarely caused by congenital structural deformity of or damage to the leaflets, chordae, and/or papillary heart muscles. It sometimes occurs with connective tissue disorders such as Marfan's syndrome, lupus eritematoso sistemico oppure Ehler's-Danlos syndrome.
Rheumatic heart disease is very common in the developing world and is a common cause of mitral regurgitation worldwide.
Mitral regurgitation symptoms
Mild mitral regurgitation may not cause any symptoms. However the symptoms associated with more severe mitral regurgitation include:
Fiato corto, especially with activity or when you lie down.
Caviglie gonfie (edema).
Mitral regurgitation treatment
Mild cases may not require any regular medication. Although medicines cannot correct mitral regurgitation, some medicines may be prescribed to help ease symptoms, or to help prevent complications by managing your blood pressure - for example, inibitori dell'enzima di conversione dell'angiotensina (ACE), 'compresse d'acqua' (diuretici) e farmaci anticoagulanti.
If you develop fibrillazione atriale, diversi farmaci possono essere utilizzati per rallentare il battito cardiaco.
Trattamento chirurgico
Surgical treatment is sometimes needed. Recent guidelines favour surgery at an earlier stage than used to be the case. The best option for you will depend on your particular circumstances.
Valve repair may be an option in some cases.
Valve replacement is needed in some cases. This may be with a mechanical or a tissue valve. Mechanical valves are made of materials which are not likely to react with your body, such as titanium. Tissue valves are made from treated animal tissue, such as valves from a pig.
Some surgical options may be possible through a catheter into the femoral vein. This avoids open heart surgery.
Recent guidelines favour replacement rather than repair in many cases. If you need surgery, a surgeon will advise on which is the best option for your situation.
What is the outlook for people with mitral regurgitation?
In some cases, the disorder is mild and causes no symptoms. If you develop symptoms they tend to become gradually worse over the years. Typical complications include insufficienza cardiaca, pulmonary artery hypertension, fibrillazione atriale e ictus. However, the speed of decline can vary. In many cases, it can take years for symptoms to become serious. Doctors use indications of how serious these complications are to decide when the best time is to refer for possible surgery. For example, when the pressure in the pulmonary artery rises above 60mmHg during exercise testing. Medication can ease symptoms but cannot repair a damaged valve.
Surgical treatment has greatly improved the outlook in most people with more severe regurgitation. Surgery has a very good success rate.
Scelte del paziente per Malattie cardiache

Salute del cuore e dei vasi sanguigni
Difetto del setto atriale
Il difetto del setto atriale (ASD) è un foro (difetto) nella parete (setto) tra le due camere superiori del cuore, o camere di raccolta (atri). Una camera è conosciuta come atrio. Il setto separa il lato sinistro e destro del cuore. Un difetto del setto è talvolta chiamato un 'buco' nel cuore. È il terzo problema cardiaco più comune con cui nascono i bambini. Molti difetti nel setto atriale si chiudono da soli e non causano problemi. Altrimenti, possono essere chiusi tramite una procedura a buco della serratura o un intervento chirurgico. La maggior parte dei bambini nati con un difetto nel setto ha una sopravvivenza normale.
di Dr Colin Tidy, MRCGP

Salute del cuore e dei vasi sanguigni
Cardiomiopatia ipertrofica
Nella cardiomiopatia ipertrofica il muscolo cardiaco diventa ispessito (ipertrofizzato) in alcune parti del cuore. Nel cuore normale, le cellule muscolari sono regolari e ordinate. Nella cardiomiopatia ipertrofica le cellule del muscolo cardiaco diventano irregolari e disordinate.
di Dr Colin Tidy, MRCGP
Domande frequenti
What is the difference between mitral regurgitation and mitral valve prolapse?
Mitral regurgitation means the mitral valve doesn't close properly, causing blood to leak backward into the left atrium when the left ventricle contracts. Mitral valve prolapse, also known as 'floppy mitral valve', is a condition where the valve is slightly deformed and bulges back into the left atrium. While mitral valve prolapse can cause a small amount of blood to leak back, leading to mitral regurgitation, they are distinct conditions.
Can mitral regurgitation be caused by conditions other than heart problems?
Yes, although rare, mitral regurgitation can sometimes be linked to congenital structural deformities of the valve components. It can also occur in individuals with some connective tissue disorders like Marfan's syndrome, systemic lupus erythematosus, or Ehlers-Danlos syndrome.
If I have mild mitral regurgitation and no symptoms, do I still need treatment?
Mild cases of mitral regurgitation may not require regular medication. While medicines cannot correct the valve problem, they can help manage symptoms or prevent complications, such as by controlling blood pressure, if needed.
What are the different types of valves used in surgical replacement?
When valve replacement surgery is needed, you might receive either a mechanical valve or a tissue valve. Mechanical valves are made from durable materials like titanium, designed not to react with your body. Tissue valves are crafted from treated animal tissue, such as valves sourced from pigs.
What factors do doctors consider when deciding if surgery is necessary for mitral regurgitation?
Doctors consider the severity of complications, such as heart failure, pulmonary artery hypertension, atrial fibrillation, and stroke, when determining the best time to refer for potential surgery. For instance, if the pressure in the pulmonary artery rises above 60mmHg during exercise testing, it suggests a need for intervention.
Ulteriori letture e riferimenti
- Profilassi contro l'endocardite infettiva: Profilassi antimicrobica contro l'endocardite infettiva in adulti e bambini sottoposti a procedure interventistiche; Linee guida cliniche NICE (marzo 2008 - ultimo aggiornamento luglio 2016)
- Nishimura RA, Otto CM, Bonow RO, et al; Aggiornamento mirato AHA/ACC 2017 della Linea guida AHA/ACC 2014 per la gestione dei pazienti con malattia delle valvole cardiache. Circulation. 2017; CIR.0000000000000503. Pubblicato originariamente il 15 marzo 2017.
- Malattia delle valvole cardiache negli adulti: indagine e gestione; Linee guida NICE (novembre 2021)
- Girdauskas E, Pausch J, Harmel E, et al; Minimally invasive mitral valve repair for functional mitral regurgitation. Eur J Cardiothorac Surg. 2019 Jun 1;55(Suppl 1):i17-i25. doi: 10.1093/ejcts/ezy344.
- Aluru JS, Barsouk A, Saginala K, et al; Valvular Heart Disease Epidemiology. Med Sci (Basel). 2022 Jun 15;10(2):32. doi: 10.3390/medsci10020032.
Informazioni sull'autoreVisualizza il profilo completo

Dr Hayley Willacy, FRCGP
Medico di base, Autore medico
MBChB (1992), DRCOG, DFFP, MRCOG (Part 1) MRCGP (2007), DFSRH (2013), MSc - medical education (2020)
La Dott.ssa Hayley Willacy era un medico di base del NHS che lavorava nel nord-ovest dell'Inghilterra, e si è ritirata dalla pratica clinica nel 2022 dopo 30 anni.
Informazioni sul recensoreVisualizza il profilo completo

Dr Colin Tidy, MRCGP
Medico di base, Autore medico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Il Dr Colin Tidy è un medico del NHS, con sede nell'Oxfordshire.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 5 Set 2028
23 Ott 2023 | Ultima versione

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