Vildagliptin per il diabete

About vildagliptin

Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called diabete (diabete mellito).

Persone con diabete need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like vildagliptin are given alongside the changes in diet.

Vildagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood.

Vildagliptin can be used by itself or alongside other medicines for diabetes, to help control your blood sugar level in different ways. Vildagliptin is available in a combination tablet with metformin to reduce the number of tablets you need to take each day.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking vildagliptin it is important that your doctor knows:

• Se sei incinta, stai cercando di avere un bambino o stai allattando.

• Se hai problemi con il funzionamento del tuo fegato o con il funzionamento dei tuoi reni.

• If you have a condition where your heart is not working as well as it should, known as heart failure.

• Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.

• Se hai mai avuto una reazione allergica a un medicinale.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about vildagliptin tablets and will provide you with a full list of the side-effects which you may experience from taking them.

• Take vildagliptin exactly as your doctor tells you to. Swallow the tablets with a drink of water.

• The usual dose is one 50 mg tablet taken twice a day (Galvus® brand), although sometimes only one dose a day is needed depending on what other medicines you are taking. Your doctor will tell you how many doses you should take and this information will also be printed on the label of the pack of tablets to remind you. If you have been told to take one dose of vildagliptin each day, take it in the morning. If you have been told to take two doses each day, take your first dose in the morning and the second dose in the evening. You can take the vildagliptin tablets before, during or after meals.

• If you have been prescribed a combination tablet of vildagliptin with metformin (Eucreas® brand) you should take one tablet twice a day, just after meals. Taking the tablets with food will reduce the risk of stomach upset which is a side-effect of metformin. There are two strengths of Eucreas® tablet - both strengths contain the same amount of vildagliptin but the amount of metformin differs. You will be prescribed the strength of tablet that fits with your current metformin dose.

• Se dimentichi di prendere una dose, prendila appena te ne ricordi (a meno che non sia quasi ora della dose successiva, in tal caso salta la dose dimenticata). Non prendere due dosi insieme per compensare una dose dimenticata.

• It is important that you keep your regular doctor's and clinic appointments. This is so that your progress can be monitored. You will need to have blood tests from time to time to make sure that your liver is working well. This is because vildagliptin can occasionally cause liver problems. The symptoms of this are feeling sick, being very tired, abdominal pain and dark-coloured urine - you must tell your doctor if you develop any of these symptoms.

• Il tuo medico potrebbe raccomandarti di controllare regolarmente il livello di zucchero (glucosio) nel sangue o nelle urine per verificare che il tuo diabete sia sotto controllo. Il tuo medico o l'infermiere specializzato in diabete ti mostrerà come fare.

• Se il tuo medico ti ha dato consigli su cambiamenti nella tua dieta, smettere di fumare o fare esercizio fisico regolare, è importante che segui i consigli che ti sono stati dati.

• Non bere alcolici, poiché possono influire sul controllo della glicemia. Chiedi al tuo medico se hai bisogno di ulteriori consigli su questo.

• Se sei un conducente, dovresti prestare particolare attenzione, poiché la tua capacità di concentrazione potrebbe essere compromessa se il tuo diabete non è ben controllato. Potresti essere consigliato di controllare i livelli di zucchero nel sangue prima di viaggiare e di avere uno spuntino con te durante i lunghi viaggi.

• Consulta il tuo medico prima di iniziare qualsiasi nuovo esercizio fisico, poiché questo avrà un effetto sui tuoi livelli di zucchero nel sangue e potresti dover controllare i livelli di sangue o urina più regolarmente.

• Make sure you know what it feels like if your blood sugar is low. This is known as hypoglycaemia, or a 'hypo'. Although vildagliptin is unlikely to cause low blood sugar, other medicines that you are taking for diabetes alongside it may. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy.

• If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and that you are taking vildagliptin.

• Se avverti una sete insolita, urini più frequentemente del normale o ti senti molto stanco, dovresti informare il tuo medico. Questi sono segni che c'è troppo zucchero nel sangue e il tuo trattamento potrebbe necessitare di un aggiustamento.

• Treatment for diabetes is usually lifelong. Continue to take vildagliptin tablets unless you are advised otherwise by your doctor.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with vildagliptin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.