Compresse di risedronato sodico
Actonel
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 12 maggio 2025
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Take risedronate sodium tablets first thing after you get up in the morning. Swallow the tablet whole with a large glass of plain water, at least half an hour before you have breakfast. Remain sitting or standing upright for at least 30 minutes after taking the tablet.
Each time you collect a prescription, make sure you have been given the same strength of tablet as you have had before. This is because there are three different strengths of risedronate sodium tablets and not all will be suitable for you.
If you buy any medicines 'over the counter', make sure your pharmacist knows that you are taking a bisphosphonate medicine, as some medicines will prevent risedronate sodium from working properly.
Una buona igiene dentale è particolarmente importante con questo trattamento - ciò significa che devi lavarti i denti regolarmente e sottoporti a controlli dentistici di routine.
A colpo d'occhio
Risedronate sodium is a bisphosphonate medicine for 'thinning' of the bones (osteoporosis) and Paget's disease of bone.
It slows bone loss in osteoporosis, increasing bone density and reducing fracture risk.
For Paget's disease, it strengthens bones, easing pain, bone damage, and fractures.
Take tablets with a large glass of water in the morning, at least 30 minutes before food or other drinks.
Remain sitting or standing upright for at least 30 minutes after taking the tablet.
Do not take mineral supplements, iron, or indigestion remedies within two hours of risedronate sodium.
See a doctor for heartburn, pain/difficulty swallowing, thigh/hip/groin pain, jaw pain/swelling, loose teeth, or ear problems.
About risedronate sodium
Tipo di medicinale | A bisphosphonate |
Utilizzato per | Osteoporosis; Paget's disease of bone |
Chiamato anche | Actonel®, Actonel Once A Week®; |
Disponibile come | Compresse |
Risedronate sodium, a bisphosphonate medicine, is prescribed for the treatment of two conditions which affect the bones. It is prescribed as a treatment for 'thinning' of the bones (osteoporosi), and it is also used to prevent bone damage in people with Malattia di Paget of bone.
Osteoporosis is a bone disease which causes bones to become brittle and fragile, making them prone to breaks and fractures. During our lifetime, old bone tissue is constantly being broken down and replaced by new bone. As we get older, our bone begins to lose density because old bone is lost faster than new bone can replace it. Women in particular have an increased risk of developing osteoporosis because they lose bone material rapidly after the menopause. Risedronate sodium slows down the rate at which old bone is lost. New bone continues to be made and this leads to an overall increase in bone density, which reduces the risk of broken bones and fractures. Bones also need calcium and colecalciferol (vitamin D3) to help keep them strong and healthy.
In Paget's disease of bone, risedronate sodium works on bones to make them stronger and help prevent bone thickening. This helps ease symptoms such as pain, bone damage and fracture.
Before taking risedronate sodium
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking risedronate sodium tablets it is important that your doctor knows:
If you are pregnant or breastfeeding. Risedronate sodium is not suitable for women who could become pregnant.
Se hai mai avuto difficoltà a deglutire.
If you are due to have any dental treatment in the near future, or if you have fare affidamento recently had a dental check-up.
Se hai problemi con il funzionamento dei tuoi reni.
Se non riesci a sederti in posizione eretta per almeno 30 minuti.
Se ti è stato detto che hai bassi livelli di calcio nel sangue.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
How to take risedronate sodium
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about risedronate sodium, and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take the tablets exactly as your doctor tells you to. There are three strengths of risedronate sodium tablets available - 5 mg, 30 mg and 35 mg. The 30 mg tablets are prescribed for people with Paget's disease, whereas people being treated for 'thinning' of the bones (osteoporosis) will receive either the 5 mg or 35 mg strength tablet. Depending upon which strength of tablet you are prescribed, your doctor will ask you to take either one dose each day oppure one dose each week. As a guide, if you are given 5 mg or 30 mg tablets, these are taken each day. If you are given 35 mg tablets, these are taken on one day of the week only. If you are unsure about how often to take your tablets, ask your pharmacist or doctor for further advice.
Take your tablet first thing after getting up in the morning. Swallow your tablet whole (do not crush or chew the tablet). Take it with a large glass of plain water, at least 30 minutes before you have any food, or other drinks or medicines. It is important that you remain sitting or standing upright for at least 30 minutes afterwards - this is to stop the tablet from getting stuck in your throat or doing any damage before it reaches your stomach.
If you forget to take your tablet first thing in the morning, you can take it when you remember later in the day, provided that you do not eat food or have anything to drink during the two hours before you take the tablet, or during the two hours afterwards. It is particularly important you do not have any milk, or any drinks containing milk during this time. If this is not possible, or if it is getting near to bedtime, then do not take a tablet on that day. If you normally take risedronate each day, just carry on as usual the next day - do not take a double dose to make up for the missed tablet. If you usually take risedronate just once a week, then take the missed dose on the following day, and then take your next dose on your usual day of the week.
If you are taking Actonel® Combi, this is a combination treatment which contains risedronate sodium tablets (Actonel®) and sachets which contain granules of calcium and colecalciferol. It is a treatment for women. You will be asked to take one Actonel® tablet on the first day of every week and one sachet of granules for the other six days of the week. Follow the instructions above for taking the tablets. To take the granules, dissolve the contents of one sachet into a glass of water, stir it to mix, and then drink it as soon as the fizzing has stopped. Foods which contain spinach, rhubarb and whole cereals can prevent you from absorbing the full amount of calcium - it is best to avoid these types of food for the two hours before and the two hours after taking the granules. Mai take risedronate tablets on the same day as you take the sachets.
Ottenere il massimo dal tuo trattamento
Do not take any mineral supplements or any indigestion remedies, or anything which might contain iron or calcium during the two hours before and the two hours after taking risedronate sodium. This is because these things interfere with risedronate sodium and stop it from being absorbed by your body. Also, you should never take risedronate sodium tablets before you get out of bed in the morning, or at bedtime.
Remember to keep your regular appointments with your doctor so that your progress can be monitored.
Good dental hygiene is important during treatment with this medicine - this means that you must brush your teeth regularly and have regular dental check-ups. You should also make sure that your dentist is aware that you are taking risedronate sodium, as some dental treatments may not be recommended for you while you are taking the tablets.
Treatment with risedronate sodium will last several months or longer. Continue to take the tablets until you are advised otherwise by your doctor.
It may be necessary for you to take supplements of calcium and vitamin D alongside this treatment. If so, your doctor will prescribe these for you.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because mineral supplements, iron preparations, and some indigestion remedies reduce the amount of risedronate sodium which your body absorbs. This could make your treatment less effective.
Eating a well-balanced diet and taking regular exercise can help your bones stay strong. Remember to follow any exercise or dietary advice your doctor gives to you.
Chemicals from tobacco can get into your bloodstream and can affect your bones, making bone loss worse. If you smoke, you should make every effort to stop. Ask your doctor or pharmacist for advice on stopping.
Can risedronate sodium cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with risedronate sodium. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common risedronate sodium side-effects (these affect fewer than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Indigestion, feeling sick (nausea), stomach ache | Attieniti a cibi semplici - evita pasti grassi o piccanti |
Diarrea | Bevi molta acqua per reintegrare i liquidi persi |
Costipazione | Cerca di seguire una dieta equilibrata e bevi diversi bicchieri d'acqua ogni giorno |
Mal di testa | Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico |
Muscle and joint pains | Chiedi al tuo farmacista di consigliare un antidolorifico adatto |
Less common, but possibly serious side-effects | Cosa devo fare se provo questa situazione? |
Stop taking the tablets and speak with your doctor as soon as possible - these may be signs that the tablets are irritating your throat | |
Dolore nella coscia, nell'anca o nell'inguine | Speak with your doctor as soon as possible - these may be signs of a thigh bone fracture |
Un dente allentato, o dolore alla mascella con gonfiore o intorpidimento | Speak with your doctor as soon as possible - these may be signs of a problem called osteonecrosis of the jaw |
Dolore all'orecchio, secrezione dall'orecchio, infezione all'orecchio | Questi potrebbero essere segni di un problema chiamato osteonecrosi dell'orecchio. Parla immediatamente con il tuo medico |
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.
How to store risedronate sodium
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati immediatamente al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
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Segnala sospetti effetti collaterali di farmaci, vaccini, sigarette elettroniche, incidenti con dispositivi medici, prodotti difettosi o falsificati (falsi) all'Agenzia regolatoria dei medicinali e dei prodotti sanitari per garantire un uso sicuro ed efficace.

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Domande frequenti
What should I do if I find it difficult to swallow risedronate sodium tablets?
If you experience any difficulty swallowing risedronate sodium, or if you have pain or burning when you swallow, you should stop taking the tablets and contact your doctor immediately. This could be a sign that the tablets are causing irritation to your throat.
Are there any specific foods or drinks I should avoid while taking risedronate sodium?
Yes, you should avoid eating foods that contain spinach, rhubarb, and whole cereals for two hours before and two hours after taking the calcium and colecalciferol granules if you're on Actonel® Combi. Additionally, you should not consume milk or drinks containing milk during the two hours before and two hours after taking your risedronate sodium tablet. Mineral supplements, iron preparations, and some indigestion remedies should also be avoided during this four-hour window, as they can interfere with the medicine's absorption.
Can I take risedronate sodium if I am pregnant or breastfeeding?
Risedronate sodium is not suitable for women who could become pregnant. If you are pregnant or breastfeeding, it is important to inform your doctor, as this medicine may not be appropriate for you.
What should I do if I experience jaw pain or a loose tooth while on risedronate sodium?
If you experience a loose tooth, jaw pain accompanied by swelling or numbness, or ear pain and discharge, you should speak with your doctor as soon as possible. These could be signs of serious problems like osteonecrosis of the jaw or ear.
How long will I need to take risedronate sodium?
Treatment with risedronate sodium will typically last for several months or even longer. You should continue to take the tablets for as long as your doctor advises you to.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Risedronate sodium Once a Week 35 mg film-coated tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated October 2020.
- Manufacturer's PIL, Risedronate sodium 5 mg film-coated tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated October 2020.
- Manufacturer's PIL, Risedronate sodium 30 mg Film Coated Tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated October 2020.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 12 maggio 2028
12 maggio 2025 | Ultima versione

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