Raloxifene for osteoporosis

About raloxifene

If you have osteoporosi, it means that you have lost some bone material and your bones have become less dense. This makes them more prone to break (fracture). The female hormone oestrogen helps to protect a woman against bone loss. When the level of oestrogen falls after the menopause, a woman can rapidly lose bone material, making her at risk of developing osteoporosis. Osteoporosis can develop over several years, often without any symptoms.

Raloxifene works by mimicking the natural effects of oestrogen. This gradually reverses the excessive breakdown of bone that happens at menopause and makes bones stronger. It is usually only prescribed for a woman who has had a bone fracture in the spine.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking raloxifene it is important that your doctor knows:

• If you have ever been treated for a blood clot in your legs or lungs.

• If you have had a stroke, or if your doctor has told you that you may be at risk of having one.

• If you have been told you have high levels of fat called triglyceride in your blood.

• If you have any problems with the way your liver works, or if you have been told you have a problem with the flow of bile from your liver (cholestasis).

• Se hai problemi con il funzionamento dei tuoi reni.

• If you are not fully mobile (such as if you have been advised to rest in bed for any reason).

• If you have noticed any vaginal bleeding.

• If you have breast cancer or endometrial cancer.

• Se hai una rara condizione ereditaria del sangue chiamata porfiria.

• Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

• Se hai mai avuto una reazione allergica a un medicinale.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about raloxifene and will provide you with a full list of the side-effects which you may experience from taking it.

• Take raloxifene exactly as your doctor tells you to. Take one 60 mg tablet each day.

• You can take raloxifene at whatever time of day you find easiest to remember but try to take your doses at the same time of day, each day. This will help you to remember to take your doses regularly. You can take the tablet either before or after a meal.

• If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses on the same day to make up for a forgotten dose.

• Treatment with raloxifene is usually long-term unless you experience an adverse event. Continue to take the tablets unless you are advised otherwise by your doctor.

• Cerca di mantenere i tuoi appuntamenti regolari con il tuo medico. Questo è per permettere al tuo medico di controllare i tuoi progressi.

• Your body needs plenty of calcium and vitamin D for healthy bones. Vitamin D is needed in order to absorb the calcium that you eat or drink from your diet. If your doctor suspects that you may not be getting enough calcium or vitamin D, you may be prescribed supplements to take in addition to raloxifene.

• Remember to follow any exercise or dietary advice that your doctor gives to you. Eating a well-balanced diet and taking some regular exercise can help your bones stay strong. Exercise (such as brisk walking, dancing or aerobics) stimulates bone-making cells and this helps strengthen your bones.

• Le sostanze chimiche del tabacco possono entrare nel tuo sangue e influenzare le tue ossa, peggiorando la perdita ossea. Se sei un fumatore, dovresti cercare di smettere se possibile. Chiedi al tuo medico o farmacista consigli su come smettere di fumare.

• As osteoporosis makes your bones weaker, they may break more easily if you fall. You can try to reduce the risk of falls by wearing well-fitting shoes or slippers, having hand rails fitted near any steps and checking your home for hazards such as uneven rugs, trailing wires and slippery floors.

• If you are due to have an operation and are likely to be advised to rest in bed for a while, please tell the person carrying out the treatment that you are taking raloxifene.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with raloxifene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.