Compresse di pizotifene
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 17 Apr 2025
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Pizotifen helps to stop migraine-type headaches from occurring.
Take the tablets regularly every day.
Having an increased appetite and feeling sleepy are the main side-effects.
At a glance
Pizotifen is a medicine used to prevent migraines, recurrent throbbing headaches, and cluster headaches.
It works by affecting chemicals in the body that can cause headaches.
You must take pizotifen every day to help stop migraine attacks from starting.
Common side-effects include increased appetite, weight gain, and feeling sleepy.
Do not drive or operate machinery if you feel sleepy from taking this medicine.
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About pizotifen
Tipo di medicinale | An antimigraine medicine |
Utilizzato per | To prevent migraines and migraine-type headaches (in adults and older children) |
Chiamato anche | Pizotyline (in US) |
Disponibile come | Compresse |
Pizotifen is taken to prevent troublesome headaches such as emicrania and recurrent throbbing headaches. It is also used to treat cluster headaches. These are headaches which occur in close succession at certain times of the year, usually lasting 6-12 weeks.
Your body produces chemicals which, in some cases, may be involved in causing headaches. These chemicals are 'serotonin', 'tryptamine' and 'histamine'. Pizotifen helps to stop the effect of these chemicals.
Pizotifen must be taken every day to help stop migraine attacks from starting. It may not completely stop every migraine attack, but the number and severity of your attacks should reduce. Although it can help to reduce the number of attacks you have, it is not effective in relieving a migraine attack that has already started.
Before taking pizotifen
Torna ai contenutiSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking pizotifen it is important that your doctor knows:
Se sei incinta o stai allattando.
If you have increased pressure in your eye, a condition called glaucoma.
If you have been experiencing difficulty passing urine.
If you have ever had fits or epilepsy.
Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
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How to take pizotifen
Torna ai contenutiBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about pizotifen, and will also provide you with a full list of the side-effects which you could experience from taking it.
Take the tablets exactly as your doctor tells you to. You will find the directions for taking the tablets on the label of the pack to remind you about what the doctor said to you. There are two strengths of tablet: 500 micrograms and 1.5 mg. It is usual to begin by taking one 500 microgram tablet a day at bedtime. Your dose may then be gradually increased to the usual maintenance dose of 1.5 mg daily (taken as one single daily dose at bedtime, or divided into three smaller doses).
Swallow the tablet with a drink of water. Try to take your doses at the same time(s) of day each day, as this will help you to remember to take pizotifen regularly. You can take the tablet either with or without food.
If you forget to take a dose at your usual time, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose and take the next dose as normal). Do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiCerca di mantenere i tuoi appuntamenti regolari con il tuo medico. Questo è per permettere al tuo medico di controllare i tuoi progressi.
For some people there may be things which trigger an attack. These can include some foods (for example, cheese, chocolate, and red wine), worry, bright sunlight, too much or too little sleep, and skipping meals. Try to avoid things that you suspect trigger your headaches.
Pizotifen can cause sleepiness. Your doctor may recommend that you do not drink alcohol while you are taking the tablets, as alcohol will increase the drowsiness.
It is unlikely that pizotifen will stop your headaches completely. You may find it useful to keep a migraine diary to monitor how well it is working. Note down when and where each attack started, what you were doing, and what you had eaten that day. A pattern may emerge and it may be possible for you to avoid some of the things that trigger your attacks.
If a migraine attack occurs despite taking pizotifen, you can still take painkillers or a triptan medicine to ease the pain and sickness.
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Can pizotifen cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with pizotifen. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common pizotifen side-effects (these affect more than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Increased appetite and weight gain | Try to eat a well-balanced diet |
Common pizotifen side-effects (these affect fewer than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Feeling sleepy, or tired | Non guidare e non utilizzare strumenti o macchinari mentre sei sotto effetto. Non bere alcolici |
Bocca secca | Prova a masticare gomme senza zucchero o a succhiare caramelle senza zucchero |
Sensazione di nausea | Attieniti a cibi semplici - evita pasti grassi o piccanti |
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.
How to store pizotifen
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati immediatamente al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
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Se acquisti dei medicinali, verifica con un farmacista che siano adatti da assumere insieme agli altri tuoi medicinali.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
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Domande frequenti
How does pizotifen work to prevent headaches?
Pizotifen helps to prevent headaches by counteracting the effects of certain chemicals in your body, specifically serotonin, tryptamine, and histamine, which are sometimes involved in causing headaches like migraines.
Is pizotifen effective for all types of headaches?
Pizotifen is specifically used to prevent migraines and migraine-type headaches, as well as to treat cluster headaches. It is not generally described as being effective for all types of headaches.
Can I stop taking pizotifen once my headaches improve?
Pizotifen needs to be taken every day to help prevent migraine attacks from starting. It's important to keep taking it as prescribed, even if your headaches improve, and to discuss any changes with your doctor.
What should I do if I experience sleepiness or tiredness from pizotifen?
If you feel sleepy or tired after taking pizotifen, you should not drive or operate machinery. It's also recommended to avoid alcohol, as it can worsen drowsiness.
Does pizotifen interact with other medicines I might be taking?
Yes, it's important to inform your doctor about all other medicines you are taking, including those bought without a prescription, herbal remedies, and complementary medicines. This is to ensure they are suitable to take with pizotifen.
Can pizotifen completely stop all my migraine attacks?
While pizotifen can significantly reduce the number and severity of migraine attacks, it may not completely stop every attack. It's also not effective for relieving a migraine that has already started.
What should I do if I still get a migraine attack while taking pizotifen?
If you experience a migraine attack even while taking pizotifen, you can still use painkillers or a triptan medicine to help ease the pain and sickness.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Pizotifen 500 mcg and 1.5 mg tablets; Sovereign Medical. The electronic Medicines Compendium. Dated July 2024.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 17 Apr 2028
17 Apr 2025 | Ultima versione

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