Fenitoina per epilessia
Epanutin
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 2 Gennaio 2024
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
Try to keep your regular doctor's appointments. Your doctor may need to test your blood to decide the correct dose for you.
You need to take phenytoin regularly. Do not stop taking it unless your doctor tells you to.
Different formulations and brands of phenytoin can act in a slightly different way in your body. Each time you collect a prescription, check to make sure your supply looks the same as you have had before. If not, please ask your pharmacist to check your prescription for you.
A colpo d'occhio
Phenytoin is an antiepileptic medicine for epilepsy and trigeminal neuralgia.
It works by stabilising brain activity to prevent seizures or modify pain.
Take phenytoin exactly as prescribed, usually with or after food.
Do not stop taking phenytoin suddenly without medical advice.
Some common side-effects include feeling sick, dizziness, and headache.
Seek medical advice if you experience mood changes, suicidal thoughts, or a severe rash.
Tell your doctor if you are pregnant, breastfeeding, or have liver problems.
About phenytoin
Tipo di medicinale | Un medicinale antiepilettico |
Utilizzato per | Epilepsy in children and adults; trigeminal neuralgia |
Chiamato anche | Phenytoin sodium, Epanutin® |
Disponibile come | Tablets, capsules, chewable tablets and oral liquid medicine |
If you have epilepsy, it means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different functions of your body, so the symptoms that occur during a seizure will depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these. The seizures can be prevented in most people by suitable antiepileptic medication. Phenytoin is a commonly used medicine. It works by stabilising the electrical activity of your brain, which prevents the seizures from occurring.
Phenytoin is also prescribed as a treatment for severe burning or stabbing pains in the face, a nerve pain called trigeminal neuralgia. This is because it can modify some types of pain. If you have been given phenytoin for this reason, ask your doctor if you have questions about your treatment.
Before taking phenytoin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if you are their carer) start taking phenytoin it is important that your doctor knows:
Se sei incinta, stai cercando di avere un bambino o stai allattando.
Se hai problemi con il funzionamento del tuo fegato.
Se hai un raro disturbo ereditario del sangue chiamato porfiria.
Se hai mai avuto una reazione allergica a un medicinale.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
How to take phenytoin
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about phenytoin and will provide you with a full list of the side-effects which you may experience from taking it.
Take phenytoin exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose.
It is important you try to take your doses at the same times each day. Having a routine will help you to remember to take your doses regularly. Although phenytoin can be taken before a meal, it is better taken during or straight after a meal.
If you are taking phenytoin chewable tablets (Epanutin® Infatabs), you can chew the tablet to help you swallow or you can swallow the tablet in the usual way with a drink of water.
If you are taking phenytoin oral liquid medicine (Epanutin® suspension), make sure that you shake the bottle well before you measure out your dose.
If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose, take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Quando inizi un nuovo trattamento per l'epilessia, potrebbe esserci un cambiamento nel numero o nel tipo di crisi che sperimenti. Il tuo medico ti consiglierà a riguardo.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests from time to time.
Durante il trattamento per l'epilessia, c'è un piccolo rischio di sviluppare cambiamenti d'umore, pensieri angoscianti e sentimenti di suicidio. Se ciò accade, devi informare immediatamente il tuo medico.
Le persone con epilessia devono smettere di guidare inizialmente. Il tuo medico ti consiglierà su quando potrebbe essere possibile ricominciare a guidare. Di solito sarà dopo un anno senza crisi epilettiche.
Different formulations and brands of phenytoin can act in a slightly different way in your body. Because of this, it is important that you continue to take phenytoin from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
If you drink alcohol, ask your doctor for advice. Your doctor may advise you not to drink alcohol while you are on this medicine because it can alter the amount of phenytoin in your body.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with your antiepileptic medication. Some indigestion remedies can interfere with the amount of phenytoin in your body.
Many antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. Phenytoin can make oral contraceptives less effective. Your doctor will advise you on other types of contraception such as an intra-uterine device (IUD) and barrier methods. You should use effective contraception throughout treatment with phenytoin and for one month after stopping. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist prima you become pregnant.
You need to take phenytoin regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.
Can phenytoin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with phenytoin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common phenytoin side-effects | Cosa posso fare se sperimento questo? |
Sensazione di malessere (nausea) o vomito | Attieniti a pasti semplici - evita cibi ricchi o piccanti |
Costipazione | Segui una dieta equilibrata e bevi molta acqua ogni giorno |
Feeling dizzy or sleepy; eyesight problems such as double vision | Non guidare e non utilizzare strumenti o macchinari mentre sei sotto effetto |
Mal di testa | Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico |
Eruzione cutanea | Let your doctor know about this as soon as possible, even if it is mild |
Difficulty sleeping, numb or tingling feelings, lack of appetite, sore or swollen gums, facial changes, acne, increased hair growth, slurred speech, lack of concentration, and feeling confused, nervous, unsteady or shaky | Se uno di questi diventa problematico, informa il tuo medico |
Importante: your doctor will discuss with you the possibility that phenytoin can cause blood and skin disorders. Although these occur less commonly than the side-effects listed above, it is important that you contact your doctor straightaway if you experience any of the following symptoms:
A high temperature (fever), sore throat or swollen glands.
A severe skin rash.
Ulcere della bocca.
Unexplained bruising or bleeding.
If you experience any other symptoms which you think may be due to phenytoin, speak with your doctor or pharmacist for further advice.
How to store phenytoin
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Se devi sottoporti a un'operazione o a un trattamento dentistico, informa la persona che esegue il trattamento sui medicinali che stai assumendo.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
MHRA - Segnalazione di reazioni avverse
Segnala sospetti effetti collaterali di farmaci, vaccini, sigarette elettroniche, incidenti con dispositivi medici, prodotti difettosi o falsificati (falsi) all'Agenzia regolatoria dei medicinali e dei prodotti sanitari per garantire un uso sicuro ed efficace.

Non sei sicuro di mescolare i medicinali?
Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.
Domande frequenti
What is the difference between different brands or formulations of phenytoin?
Different brands and formulations of phenytoin (such as tablets, capsules, or liquid) can act slightly differently in your body. It is important to stick to the same manufacturer and brand of phenytoin you have been prescribed. Always check your supply to ensure it looks the same and the brand name matches what you've had before. If you have any questions, your pharmacist can help.
Do I need blood tests while taking phenytoin?
Yes, you will need to have blood tests from time to time while taking phenytoin. These tests allow your doctor to monitor your progress and ensure the medication is working effectively and safely for you.
Can I stop taking phenytoin if I feel better?
No, you should not stop taking phenytoin suddenly, even if you feel better. This medication needs to be taken regularly every day. Stopping treatment abruptly can cause problems. If it becomes necessary to stop, your doctor will advise you on how to gradually reduce your dose.
What should I do if I develop a severe skin rash while on phenytoin?
You should contact your doctor straight away if you experience a severe skin rash. While many side-effects improve as your body adjusts, a severe rash could be a sign of a more serious, less common problem, and your doctor will need to assess it.
What should I do if I suspect an overdose of phenytoin?
If you suspect that you or someone else might have taken too much phenytoin, you should go to the accident and emergency department of your local hospital immediately. Remember to take the container with you, even if it is empty.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Phenytoin sodium 100 mg film-coated tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated September 2022.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 1 Gen 2027
2 Gennaio 2024 | Ultima versione

Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.
Altri farmaci del sistema nervoso
- Compresse di agomelatina
- Iniezione a lunga durata d'azione di aripiprazolo
- Atomoxetina per ADHD
- Buprenorfina per il sollievo dal dolore
- Citalopram
- Duloxetina per disturbi dell'umore e nervosi
- Eletriptan per emicrania
- Lamotrigina per epilessia
- Compresse di levomepromazina
- Lurasidone
- Compresse di Nimodipina
- Iniezione a lunga durata di Paliperidone
- Rizatriptan per emicrania
- Rufinamide per l'epilessia
- Sertralina
- Temazepam
- Tizanidina per spasmi muscolari
- Valproato semisodico per il disturbo bipolare
- Vigabatrin per l'epilessia
- Vortioxetina per la depressione