Iniezione a lunga durata di Flufenazina
discontinued
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 12 Dic 2022
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Nota dell'autore clinico Michael Stewart 05/12/2022: Modecate® injections were discontinued in the United Kingdom in November 2020. At the time of review there are no licensed injection products containing fluphenazine available in the UK. Fluphenazine injections may still be available in other countries or as special order products. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Fluphenazine long-acting injection will be given to you by your clinic doctor or nurse every 2-5 weeks.
If you miss an appointment for an injection, make another appointment as soon as possible.
If you either start or stop smoking whilst you are being treated with fluphenazine, tell your doctor. Your dose may need to be adjusted.
A colpo d'occhio
Fluphenazine long-acting injection is an antipsychotic medicine given for schizophrenia and similar mental health problems.
It is a 'depot' injection given into a muscle every 2–5 weeks to maintain symptom control.
Tell your doctor about existing health conditions or medicines before starting treatment.
Avoid strong sunlight and sunbeds, and use high-factor sun cream whilst on this injection.
Keep regular appointments for injections and monitoring.
Contact your doctor immediately if you experience muscle stiffness, high temperature, confusion, sweating, fast heartbeat, and urinary incontinence.
About fluphenazine long-acting injection
Tipo di medicinale | An antipsychotic injection |
Utilizzato per | Maintenance of symptom control in adults with schizophrenia and other similar mental health problems |
Chiamato anche | Fluphenazine decanoate; Modecate® (discontinued) |
Disponibile come | Long-acting 'depot' injection |
Fluphenazine belongs to a group of medicines called antipsicotici. You will have been prescribed it to maintain symptom control of schizofrenia.
Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs, feeling unusually suspicious, and becoming withdrawn. Fluphenazine is used to relieve the symptoms of schizophrenia and other similar mental health problems. It works on the balance of chemical substances in your brain.
Long-acting, or 'depot', injections are used once your symptoms have been eased by taking tablets. The injection slowly releases fluphenazine into your body and is given every 2-5 weeks. The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having fluphenazine long-acting injection
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start having fluphenazine injections, it is important that your doctor knows:
Se sei incinta o stai allattando.
If you know you have a heart condition or blood vessel disease (such as any thickening of the arteries in your head).
Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.
Se hai problemi alla prostata.
If you have a blood disorder.
Se hai problemi con la respirazione.
If you have any of the following: epilepsy, depression, Parkinson's disease, raised pressure in your eye (glaucoma), thyroid problems, or a condition which causes muscle weakness, called myasthenia gravis.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice).
Se hai un tumore alla ghiandola surrenale (una condizione chiamata feocromocitoma).
Se hai avuto una reazione allergica a un medicinale.
Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
How fluphenazine long-acting injection is given
Before you start this treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about fluphenazine, and it will also provide you with a full list of the side-effects which you could experience.
Fluphenazine long-acting injection will be given to you by a doctor or nurse. If you haven't received an injection like fluphenazine before, a small dose is usually given as a test 4-7 days before you have a full dose. This is to see how well you tolerate the injection. The injection is given into a muscle in your bottom (buttocks).
You may be asked to continue taking your currently prescribed tablets for a short while after you have had your first injection. This is because it can take a few weeks before you feel the full effect from the injection.
Treatment with fluphenazine is usually long-term so that your symptoms don't return.
Ottenere il massimo dal tuo trattamento
Your treatment will require careful monitoring to make sure that you get the best possible benefit from fluphenazine. Keep your regular doctor's appointments so that you get your injections on time, and your progress can be checked. If you miss an appointment for an injection, contact your doctor to arrange for another appointment as soon as possible.
Medicines similar to fluphenazine can cause people to become more sensitive to sunlight than normal. It is recommended that you avoid strong sunlight and sunbeds, and use a sun cream with a high sun protection factor even on bright but cloudy days.
If you drink alcohol, ask your doctor for advice about drinking while you are on fluphenazine. Alcohol can increase the chance that you experience side-effects and may not be advisable for you.
Smoking can interfere with the way your body handles fluphenazine. If you either start smoking or quit smoking whilst you are having fluphenazine, please make sure that you tell your doctor. It is probable that your dose will need to be adjusted.
If you have diabetes you may need to check your blood glucose more frequently, as fluphenazine can affect the levels of sugar in your blood. Your doctor will advise you about this.
If you are having any dental treatment or an operation, tell the person carrying out the treatment that you have had a fluphenazine injection. This is important because it may interfere with the anaesthetic or painkillers you receive.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with fluphenazine.
Can fluphenazine long-acting injection cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with fluphenazine. The best place to find a full list of the side-effects which can be associated with your injection, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Fluphenazine side-effects | Cosa posso fare se sperimento questo? |
Pain at the site of the injection | This should not last long. If the area becomes red, swollen or 'lumpy', let your doctor know |
Feeling sleepy or dizzy, blurred vision | Non guidare e non utilizzare strumenti o macchinari mentre sei sotto effetto |
Bocca secca | Prova a masticare gomme senza zucchero o a succhiare caramelle senza zucchero |
Unusual or uncontrollable muscle movements, feeling shaky | Parla con il tuo medico di questi |
Feeling restless, movement problems | Speak with your doctor |
Mal di testa | Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, consulta il tuo medico |
Changes in weight, stuffy nose, difficulty sleeping, feeling agitated or confused, sexual problems, breast changes, menstrual problems, fast heartbeats, poor judgement or reduced mental ability, stomach upset, constipation, and difficulty passing urine | Discuti questi con il tuo medico se qualcuno diventa problematico |
Importante: if you experience symptoms such as muscle stiffness, a very high temperature, feeling confused or sweaty, a fast heartbeat, and urinary incontinence, you should contact your doctor immediately. These can be signs of a rare but serious condition known as neuroleptic malignant syndrome.
If you experience any other symptoms which you think may be due to the injection, speak with your doctor or pharmacist for further advice.
How to store fluphenazine long-acting injection
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
If you suspect that you have had an overdose of this medicine, contact the accident and emergency department of your local hospital for advice.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
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Domande frequenti
What is the difference between fluphenazine tablets and the long-acting injection?
Fluphenazine tablets are typically used to initially ease symptoms. Once symptoms are under control, the long-acting injection, also known as a 'depot' injection, is used for maintenance. The main advantage of the injection is that it slowly releases the medication into your body over 2-5 weeks, meaning you don't have to remember to take tablets every day.
Why is a test dose given before the full fluphenazine long-acting injection?
If you haven't received a fluphenazine injection before, a small test dose is usually administered 4-7 days prior to the full dose. This is done to assess how well your body tolerates the injection before you receive the complete treatment.
How long will I need to continue taking fluphenazine long-acting injections?
Treatment with fluphenazine is usually long-term. This is to help prevent your symptoms from returning, ensuring ongoing symptom control.
Can fluphenazine affect my blood sugar if I have diabetes?
Yes, fluphenazine can affect the levels of sugar in your blood. If you have diabetes, your doctor may advise you to check your blood glucose more frequently while on this medication.
Is it safe to get dental treatment or an operation while on fluphenazine injections?
If you are having any dental treatment or an operation, it is important to inform the person carrying out the treatment that you have had a fluphenazine injection. This is because it could potentially interact with any anaesthetics or painkillers you might receive.
Ulteriori letture e riferimenti
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 11 giu 2027
12 Dic 2022 | Ultima versione

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