Idromorfone per il dolore da cancro
Palladone
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 24 Feb 2023
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This medicine is an opioid painkiller. There is a serious risk of addiction when taking this medicine, especially if used long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued nuove linee guida per le persone a cui è stato prescritto un antidolorifico oppioide. Se hai domande o preoccupazioni sull'assunzione sicura di oppioidi, ti preghiamo di parlare con il tuo medico o un farmacista.
Hydromorphone eases severe pain associated with cancer.
The capsules can be swallowed whole with a drink of water, or opened and the contents sprinkled on to some soft food such as yoghurt.
The most common side-effects are constipation, drowsiness and feeling sick (nausea). Your doctor may prescribe medicines for you to take with hydromorphone to help with some of these side-effects.
A colpo d'occhio
Hydromorphone is a strong opioid painkiller prescribed for severe cancer pain.
It is available as quick-acting or modified-release capsules.
Tell your doctor about existing health conditions, especially liver, kidney, or breathing problems.
Always take hydromorphone exactly as your doctor instructs.
Do not suddenly stop taking hydromorphone without medical advice.
Common side-effects include feeling sick, dizziness, drowsiness, and constipation.
Seek immediate medical help if you experience signs of overdose like severe sleepiness or breathing difficulties.
About hydromorphone
Tipo di medicinale | Antidolorifico oppioide forte |
Utilizzato per | Pain relief in adults with cancer |
Chiamato anche | Palladone® |
Disponibile come | Capsules, and modified-release capsules |
Oppioidi forti are medicines used to treat severe pain. Hydromorphone is a type of strong opioid (sometimes called an opiate) used to treat pain caused by cancro. It works on your nervous system and brain to reduce the amount of pain you feel.
Hydromorphone is taken by mouth as a capsule. There are two types of capsule available: quick-acting capsules (Palladone®) and modified-release capsules (Palladone® SR). Modified-release capsules release the hydromorphone they contain more slowly than the quick-acting capsules do. This provides longer and more even pain relief.
Before taking hydromorphone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking hydromorphone it is important that your doctor knows:
Se sei incinta, stai cercando di avere un bambino o stai allattando.
Se hai problemi al fegato o ai reni.
Se hai problemi alla prostata o difficoltà a urinare.
Se hai problemi respiratori, come l'asma o la broncopneumopatia cronica ostruttiva (BPCO).
If you have been told you have low blood pressure (hypotension).
If you have any problems with your thyroid, pancreas, or adrenal glands.
Se hai l'epilessia.
Se hai un problema con il tuo dotto biliare.
Se sei stato stitico per più di una settimana o hai un problema infiammatorio intestinale.
Se hai una condizione che causa debolezza muscolare, chiamata miastenia grave.
If you have a mental health problem called toxic psychosis.
Se hai avuto di recente una grave lesione alla testa.
Se sei mai stato dipendente da droghe o alcol.
Se hai mai avuto una reazione allergica a un medicinale.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
How to take hydromorphone
Before you start taking the capsules, read the manufacturer's printed information leaflet from inside the pack. The manufacturer's leaflet will give you more information about hydromorphone and a full list of the side-effects which you may experience from taking it.
Take hydromorphone exactly as your doctor tells you to. If you have been prescribed the quick-acting capsules (Palladone®), you will be asked to take a dose every four hours. The modified-release capsules (Palladone® SR) are taken twice a day, 12 hours apart.
There are different strengths of both types of hydromorphone capsule, so each time you collect a prescription check to make sure it is the strength you are expecting.
You can swallow the capsules whole with a drink of water, or alternatively, open them and sprinkle the contents on to some soft food, such as yoghurt. Do not dissolve or chew the contents of the capsule as this may release all the medicine at once and cause side-effects.
You can take hydromorphone before or after food.
If you forget to take a dose, take it as soon as you remember and then continue as before. If it is nearly time for your next dose, leave out the forgotten dose and take the next dose when it is due. Do not take two doses together to make up for a forgotten dose. If you are taking quick-acting capsules do not take more than one dose every four hours.
Ottenere il massimo dal tuo trattamento
Ask your doctor for advice before drinking alcohol while you are on this medicine. Your doctor may recommend you do not drink alcohol while you are on hydromorphone because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that hydromorphone is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, should you drive, you are advised to carry with you some evidence that the medicine has been prescribed for you - a repeat prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking hydromorphone as a painkiller.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with hydromorphone. Many other medicines have similar side-effects to hydromorphone, and taking them together will increase the risk of these.
If you are planning a trip abroad, you are advised to carry a letter with you from your doctor to explain that you have been prescribed hydromorphone. This is because hydromorphone is classed as a 'controlled drug' and is subject to certain restrictions.
Continue to take hydromorphone unless your doctor tells you otherwise. Stopping suddenly will cause your pain to return, and it can also cause you to feel agitated, anxious, and sweaty. If you need to stop taking hydromorphone your doctor will prescribe an alternative painkiller for you, or reduce your dose gradually.
Can hydromorphone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with hydromorphone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common hydromorphone side-effects | Cosa posso fare se sperimento questo? |
Sensazione di malessere (nausea) o vomito | Stick to simple meals - avoid rich or spicy foods. Also, try taking your doses after food, as this may help |
Shallow breathing | Informi il suo medico di questo |
Sensazione di vertigini, sonnolenza o stordimento | Se ciò accade, non guidare e non utilizzare strumenti o macchinari. Non bere alcolici |
Costipazione | Try to eat a well-balanced diet and drink plenty of water each day. If this continues to be a problem, speak with your doctor who may prescribe a laxative for you |
Bocca secca | Prova a masticare gomme senza zucchero o a succhiare caramelle senza zucchero |
Other common side-effects include: feeling confused or disorientated, itching, sweating, mood changes, disturbed sleep, headache, difficulties passing urine, flushing, and rash | Se uno di questi diventa problematico, parla con il tuo medico |
Importante: people taking opioid medicines, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:
Sensazione di molta sonnolenza o vertigini.
Sensazione di malessere (nausea) o vomito.
Difficoltà respiratorie.
Perdita di coscienza.
If you have taken more morphine than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.
Se si verificano altri sintomi che ritieni possano essere dovuti a questo medicinale, parla con il tuo medico o farmacista.
How to store hydromorphone
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Sito web Yellow Card.

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Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.
Domande frequenti
Can I take hydromorphone if I am pregnant or breastfeeding?
If you are pregnant, trying for a baby, or breastfeeding, it is important to let your doctor know before you start taking hydromorphone. Your doctor will need to consider this information to ensure the medicine is suitable for you.
Is it safe to drive while taking hydromorphone?
Hydromorphone is likely to affect your reactions and your ability to drive. It is an offence to drive if your reactions are impaired. Even if you feel your driving ability is not impaired, you should carry evidence that the medicine has been prescribed for you, such as a repeat prescription form or a patient information leaflet, in case you are stopped.
What should I do if I need to stop taking hydromorphone?
You should continue to take hydromorphone unless your doctor tells you otherwise. If you need to stop, your doctor will either prescribe an alternative painkiller or gradually reduce your dose. Stopping suddenly can cause your pain to return and may also lead to agitation, anxiety, and sweating.
What should I do if I experience constipation while taking hydromorphone?
Constipation is a common side-effect. You can try to eat a well-balanced diet and drink plenty of water daily to help. If constipation continues to be a problem, speak with your doctor, as they may be able to prescribe a laxative for you.
How should I store my hydromorphone capsules?
You should keep all medicines, including hydromorphone, out of the reach and sight of children. Store them in a cool, dry place, away from direct heat and light.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Palladone® 1.3 mg and 2.6 mg capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Manufacturer's PIL, Palladone® SR capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 23 Ago 2027
24 Feb 2023 | Ultima versione

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