Co-phenotrope tablets for diarrhoea
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 27 Apr 2023
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The usual dose for acute diarrhoea in an adult is four tablets to start with, followed by two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.
When you have diarrhoea it is important that you have lots of water to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Eat as normally as possible, as soon as you feel able.
If your symptoms continue for more than 48 hours, speak with a doctor for advice if you have not already done so.
Co-phenotrope must not be taken by children under 16 years of age unless prescribed by a doctor.
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About co-phenotrope
Tipo di medicinale | An antimotility medicine |
Utilizzato per | Diarrea |
Chiamato anche | Diphenoxylate hydrochloride with atropine sulfate |
Disponibile come | Compresse |
Co-phenotrope is used in acute diarrhoea (this is diarrhoea which starts suddenly and lasts less than two weeks). It contains two ingredients: diphenoxylate hydrochloride and atropine sulfate. It is the diphenoxylate hydrochloride which is the main ingredient.
The most common cause of acute diarrhoea is infection. Other causes include drinking lots of beer, as a side-effect from other medicines, and anxiety. In most cases the diarrhoea settles within a few days, although it may take longer in some people. The main treatment is to have lots to drink to prevent lack of fluid in the body (dehydration). Antidiarrhoeal medicines like co-phenotrope may not be necessary; however, if you wish to reduce the number of trips that you need to make to the toilet, it can be useful. Most people only need to take it for a few days.
Diphenoxylate works by slowing down the activity of your bowel. This reduces the speed at which the contents pass through, and so food remains in your intestines for longer. This allows more water to be absorbed back into your body and results in firmer stools that are passed less often.
Because co-phenotrope regulates the passage of food through the digestive system, the tablets are also prescribed to help people regulate their bowel activity following surgery on the intestines.
Before taking co-phenotrope
Torna ai contenutiSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-phenotrope it is important that your doctor or pharmacist knows:
Se sei incinta o stai allattando.
Se hai problemi con il funzionamento del tuo fegato o dei tuoi reni.
Se hai problemi respiratori, come l'asma o la broncopneumopatia cronica ostruttiva (BPCO).
Se hai problemi alla prostata o difficoltà a urinare.
Se ti è stato detto che hai la pressione bassa.
Se hai problemi con la tiroide o le ghiandole surrenali.
Se hai l'epilessia.
If you have a problem in your bile duct.
If you have a bowel obstruction or an inflammatory bowel problem.
Se hai una condizione che causa debolezza muscolare, chiamata miastenia grave.
If you have ever had a drug addiction.
Se hai mai avuto una reazione allergica a un medicinale.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
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How to take co-phenotrope
Torna ai contenutiBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about the tablets and a full list of the side-effects which you may experience from taking them.
Start by taking four tablets, and then take a further two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.
Co-phenotrope should not be taken by a child under 16 years of age unless it is on the advice of a doctor. If your child has been prescribed co-phenotrope, check the label carefully to make sure you know what dose to give, as the dose will depend upon your child's age.
If you forget to take a dose, do not worry, just take a dose after the next time you pass some diarrhoea. Do not take two doses together to make up for a missed dose.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiIt is important that you have lots to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Drinking plain water is ideal, but juice and/or soup are also suitable. Try to avoid drinks that contain a lot of sugar, such as cola or pop, as they can sometimes make diarrhoea worse.
Oral rehydration salts can be taken to help prevent dehydration and replace lost salts. These are especially recommended for children and for people who are frail or who have underlying health problems. You can buy these from a pharmacy.
Eat small, light meals as soon as you are able. Plain foods such as wholemeal bread and rice are good foods to try eating first.
If your symptoms continue for more than 48 hours, speak with a doctor or pharmacist for advice if you have not already done so.
If your symptoms get worse, or if you develop a high temperature, or if you pass blood in the diarrhoea, you should ask your doctor or pharmacist for advice as soon as possible.
If you buy any medicines check with a pharmacist that they are suitable to take with co-phenotrope. This is because the risk of side-effects can be increased when co-phenotrope tablets are taken with some other medicines.
Do not take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, or that a child has taken it by accident, go to the accident and emergency department of your local hospital straightaway. Take the container with you, even if it is empty.
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Can co-phenotrope cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with co-phenotrope. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Co-phenotrope side-effects | Cosa posso fare se sperimento questo? |
Feeling tired, sleepy or dizzy | Se ciò accade, non guidare e non utilizzare strumenti o macchinari finché non ti senti meglio |
Mal di testa | Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico |
Tummy (abdominal) discomfort, feeling sick (nausea) | Try taking the tablets after eating some food if you are not already doing so |
Costipazione | Stop taking co-phenotrope |
Feeling confused or restless, mood changes, high temperature (fever), dry mouth, difficulty passing urine, feeling flushed | These should soon pass. If any become troublesome, stop taking co-phenotrope |
Se si verificano altri sintomi che ritieni possano essere dovuti al medicinale, parla con il tuo medico o farmacista.
How to store co-phenotrope
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Se devi sottoporti a un'operazione o a un trattamento dentistico, informa la persona che esegue il trattamento sui medicinali che stai assumendo.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
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Ulteriori letture e riferimenti
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 26 Oct 2027
27 Apr 2023 | Ultima versione

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