Compresse per dormire
Revisione paritaria di Dr Hayley Willacy, FRCGP Ultimo aggiornamento di Dr Colin Tidy, MRCGPUltimo aggiornamento 18 Nov 2022
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Doctors avoid prescribing sleeping tablets if possible due to the problems they can cause and the concern that you could become dependent on them.
A colpo d'occhio
Taking sleeping tablets daily can lead to needing higher doses for them to work.
Some people can become dependent on sleeping tablets, experiencing withdrawal symptoms if stopped suddenly.
Sleeping tablets can cause next-day drowsiness, clumsiness, and confusion.
Short courses of sleeping tablets may be helpful for temporary sleep problems.
Your doctor will discuss the risks, benefits, and how long you might take them for.
Are sleeping tablets bad for you?
In particular, the concern is that you could become dependent on sleeping aids or addicted to them. Possible problems when taking sleeping tablets include the following:
Drowsiness the next day
You may not be safe to drive a vehicle or to operate machinery due to the sedating effect. Evidence shows people who take sleeping tablets are more likely to be involved in road traffic accidents.
Clumsiness, drowsiness, and confusion in the night (if you get up)
These can occur - for example, if you have to get up in the middle of the night to go to the toilet. You may fall over and injure yourself if you feel sleepy. Some people have fallen down stairs due to the drowsiness caused by sleeping tablets. (Older people who take sleeping tablets have an increased risk of breaking their hip, as the result of a fall.)
Rischi
One study suggests that people who use sleeping tablets for a long time are more likely to develop dementia. (This has not been proven yet.)
Tolleranza
If you take sleeping medicine such as benzodiazepines and Z drug sleeping tablets to treat insomnia each night, your body becomes used to them. This means that, in time, the usual dose has no effect. You then need a higher dose for it to work. In time, the higher dose does not work and you need an even higher dose, and so on. It can take as little time as just a few days for tolerance to develop.
Dipendenza
Some people become dependent on benzodiazepines or Z drugs. This means that withdrawal symptoms occur if the tablets are stopped suddenly. Withdrawal symptoms include mental health problems such as anxiety, shaking, or just feeling awful. If you have taken a benzodiazepine or Z drug regularly for more than two to four weeks, you will need to come off it gradually, to avoid withdrawal symptoms.
Dipendenza
Some people who are dependent on benzodiazepines or Z drugs may become addicted to them. If you are addicted to a medication, you have uncontrollable cravings for it and feel a need to take it. This can happen even after you have slowly withdrawn from it so that you are no longer dependent. Tolerance, dependence and addiction are different things. Some types of people seem more likely than others to become addicted to substances.
In some cases, however, sleeping tablets may be very helpful. In short courses for time-limited problems, they are safe to use. For example, if you have had a sudden shock or bereavement, sleeping can be a problem. A short course of sleeping tablets (for a week or two) may help you cope better in the daytime. Or if you have jet lag and are struggling with re-setting your internal time clock. Doctors advise that you take no more than two weeks of sleeping tablets at a time. If you just take the tablets for a week or two, you will not become dependent on them.
How do sleeping tablets work?
Sleeping tablets work either by a general affect on the brain to promote drowsiness or by directly binding with receptors in the brain to cause sleepiness or relaxation. There are different types of sleeping pills that work in different ways, but all generally affect the brain in some way to promote sleep. It is also thought that there is an additional placebo affect, which means that just by taking the tablets, you may feel more relaxed and positive about getting to sleep, and therefore more likely to get a better night's sleep.
Are there different types of sleeping tablet?
Benzodiazepine e farmaci Z
Benzodiazepines and Z drugs are sometimes used as sleeping tablets. Benzodiazepines include temazepam, loprazolam, lormetazepam, and nitrazepam. They are only available on prescription. Other related drugs called zaleplon (no longer available in the UK), zolpidem e zopiclone are also sleeping tablets. Strictly speaking, they are not benzodiazepines. They are known as the Z drugs. However, they act in a similar way (they have a similar effect to benzodiazepines on the brain cells).
Antistaminici
These medicines are commonly used to treat allergic reactions such as hay fever. However, drowsiness is a side-effect of some antihistamines - for example, prometazina. This 'side-effect' is useful in some people who have difficulty sleeping because of their allergy. An antihistamine is the active ingredient of some sleeping tablets that you can buy from pharmacies, without a prescription. Antihistamines are not as powerful as benzodiazepines or Z drugs at causing sleep. Also, they may cause a 'hangover' effect and some drowsiness in the morning. They may also cause rebound insomnia if you take them for a long time. For these reasons, current UK guidelines do not advise the use of antihistamines to be used solely as a sleeping tablet.
Melatonina
Melatonina is, strictly speaking, not a 'sleeping tablet'. Melatonin is a naturally occurring hormone made by the body. The level of melatonin in the body varies throughout the day. It is involved in helping to regulate the daily cycles (circadian rhythms) of various functions in the body. A melatonin supplement is sometimes advised in older people (more than 55 years of age) with sleep disorders such as long-term insomnia. The recommended duration of treatment is for three weeks to start with. If helpful, it can be used for a maximum of ten weeks in total.
In some countries melatonin is used to help with sleep problems related to jet lag. In the UK it is not currently licensed for this.
Altri farmaci
Chlormethiazole, chloral, and barbiturates are old-fashioned sleeping tablets. They are not commonly used these days, as benzodiazepines and Z drugs are usually preferred. Certain antidepressants are sometimes used to help with sleep, particularly if depression or anxiety is thought to be causing the problem.
What is the alternative to sleeping tablets?
Try to work out the reason for your sleeping difficulties and identify any specific factors that counter sleep. Where possible, correct any or all of these factors.
Your doctor or nurse may give you advice on how to tackle poor sleep naturally. They may also refer you for a type of talking therapy called cognitive behavioural therapy (CBT). CBT is a type of brain-training, which aims to teach your brain how to fall and stay asleep.
Vedi anche il foglio separato intitolato Insonnia (Sonno Scarso).
Do I need a prescription for sleeping tablets?
If your doctor or pharmacist prescribes a benzodiazepine or Z drug as a sleeping tablet for you, it will usually be only short-term (a week or so). This is to help you get over a particularly bad patch and get a good night's sleep. Sometimes a doctor will advise sleeping tablets to be taken on only two or three nights per week, rather than on every night. This prevents either tolerance to or dependence on the tablet from developing.
Can you take sleeping tablets every night?
For various reasons, some people have become used to taking a benzodiazepine or Z drug sleeping tablet every night. As a rule, if you are taking one of these sleeping tablets each night, you should consider reducing or stopping them. However, in some people, problems of tolerance or dependence (see above) mean that it can be difficult to stop the tablet suddenly.
If you want to reduce or stop benzodiazepine or Z drug sleeping tablets, it is best to consult a doctor or nurse for advice. The sort of advice may include the following:
Do it gradually and cut the dose down a little at a time. A switch to a different benzodiazepine (diazepam) may be advised. This is because it is easier to reduce the dose of diazepam gradually than it is with other benzodiazepines or Z drugs.
It is best to wait until any life crisis has passed and your level of stress is as low as can be.
Consider stopping the tablets whilst on holiday, when you have less pressure from work, family, etc.
You are likely to have a period of worse sleep when you stop the tablets. Try to anticipate and accept this.
Advice on coping strategies, and tips on how to improve your sleep pattern naturally.
See the separate leaflet called Stopping Benzodiazepines and Z Drugs. However, stopping benzodiazepine or Z drug sleeping tablets is not practical in every case.
How many sleeping tablets are harmful?
The National Institute for Health and Care Excellence (NICE) has published guidance on safe prescribing and stopping medicines that can lead to addiction or withdrawal symptoms in adults. They have concentrated on benzodiazepine e farmaci Z which are often used for sleep issues, as well as some medication used for pain relief (oppioidi, gabapentin e pregabalin). They have also discussed antidepressants which are not addictive but can cause withdrawal symptoms.
Prima di prescrivere, il tuo medico prenderà in considerazione:
Se sono stati provati altri metodi o farmaci che non creano dipendenza.
Issues that could lead you to becoming addicted to the medication
Che tu abbia tutte le informazioni necessarie per prendere una decisione.
Cosa dovresti sapere quando inizi un farmaco:
Il tipo di farmaco e il motivo per cui ti è stato prescritto.
La dose iniziale e quando le dosi verranno modificate se necessario.
Gli effetti collaterali e quanto tempo possono durare.
Chi contattare in caso di domande o preoccupazioni.
Quanto tempo impiegherà il farmaco a fare effetto e per quanto tempo lo assumerai.
How long the prescription given is for - eg, one week, two weeks
I rischi di dipendenza e overdose.
Quando avrai una recensione.
Il tuo medico potrebbe interrompere il farmaco se:
Non c'è alcun beneficio o non ti sta più aiutando.
Ci sono sintomi o segni di dipendenza.
La tua malattia è migliorata.
Ci sono più danni che benefici nell'assumere il farmaco.
Tu, come paziente, vuoi interrompere il farmaco.
The doctor will stop the medication slowly. They will discuss with you how to do this taking into account issues that may make stopping the medication difficult.
A note on withdrawing from benzodiazepines: if you are on medications such as lorazepam or nitrazepam, you may be switched to diazepam. This medication has a longer half life, meaning it will stay in your body longer reducing any withdrawal effects. Terapia cognitivo comportamentale La terapia cognitivo-comportamentale (CBT) insieme alla sospensione di una benzodiazepina può anche aiutare a gestire i sintomi. Il tuo medico potrebbe indirizzarti alla CBT mentre interrompi questo tipo di farmaco.
For Further Reading, see below.
Scelte del paziente per Sonno e insonnia

Vita sana
Narcolessia e cataplessia
La narcolessia è un problema a lungo termine (cronico) che influisce sul sonno. Ti senti eccessivamente stanco durante il giorno, ma hai un sonno disturbato durante la notte. Puoi anche avere attacchi di sonno in cui ti addormenti durante il giorno senza preavviso. Molte persone con narcolessia hanno anche la cataplessia. Questa è una condizione in cui si verifica una perdita improvvisa di controllo su alcuni muscoli. La narcolessia viene di solito diagnosticata monitorandoti mentre dormi in un laboratorio del sonno speciale. Non esiste una cura per la narcolessia. Tuttavia, sono disponibili vari trattamenti che possono aiutare a controllare i tuoi sintomi. Questi includono farmaci stimolanti per impedirti di sentirti così assonnato.
di Dr Caroline Wiggins, MRCGP

Vita sana
Calcolatore del debito di sonno
Apri il calcolatore del debito di sonno.
dal team di informatica per i pazienti
Domande frequenti
Can I buy sleeping pills that are not prescription-only?
Yes, some sleeping tablets containing antihistamines are available to buy from pharmacies without a prescription. However, these are not as strong as prescription medications like benzodiazepines or Z drugs, and they can cause drowsiness the next morning or rebound insomnia if used for a long time.
What specifically is a 'Z drug'?
Z drugs are a group of sleeping tablets that include zaleplon (no longer available in the UK), zolpidem, and zopiclone. While not technically benzodiazepines, they work in a similar way by affecting brain cells to promote sleep.
What is melatonin and how is it used for sleep?
Melatonin is a hormone naturally produced by the body that helps regulate daily sleep-wake cycles. A melatonin supplement may be recommended for older people (over 55) with long-term insomnia, typically for three weeks initially and a maximum of ten weeks. In some countries, it's used for jet lag, but it's not licensed for that in the UK.
Are there older types of sleeping tablets that are no longer commonly used?
Yes, medicines like chlormethiazole, chloral, and barbiturates are considered old-fashioned sleeping tablets. They are not commonly used today, with benzodiazepines and Z drugs generally preferred by doctors.
If I am prescribed sleeping tablets, how long can I expect to take them for?
If your doctor prescribes a benzodiazepine or Z drug, it's usually for a short period, often a week or so, to help you through a difficult time and improve sleep. Doctors generally advise taking sleeping tablets for no more than two weeks at a time to prevent dependence, and sometimes they may suggest taking them only two or three nights a week.
Why might a doctor prescribe an antidepressant for sleep problems?
Certain antidepressants are sometimes used to help with sleep, especially if your sleep difficulties are thought to be caused by underlying depression or anxiety.
Ulteriori letture e riferimenti
- Insonnia - zaleplon, zolpidem e zopiclone per la gestione dell'insonnia; Linee guida di valutazione tecnologica NICE, aprile 2004
- Dichiarazione di consenso sul trattamento basato sull'evidenza dell'insonnia, delle parasonnie e dei disturbi del ritmo circadiano; Associazione Britannica di Psicofarmacologia (2010)
- Buysse DJ, Germain A, Moul DE, et al; Efficacia del trattamento comportamentale breve per l'insonnia cronica negli anziani. Arch Intern Med. 23 maggio 2011;171(10):887-95. Pubblicato online il 24 gennaio 2011.
- Taibi DM, Landis CA, Petry H, et al; Una revisione sistematica della valeriana come aiuto per il sonno: sicura ma non efficace. Sleep Med Rev. 2007 Giugno;11(3):209-30.
- Buysse DJ; Insonnia. JAMA. 20 Feb 2013;309(7):706-16. doi: 10.1001/jama.2013.193.
- Formulario Nazionale Britannico (BNF); Servizi di Evidenza NICE (accesso solo nel Regno Unito)
- Luik AI, Kyle SD, Espie CA; Terapia Cognitivo Comportamentale Digitale (dCBT) per l'Insonnia: una Revisione dello Stato dell'Arte. Curr Sleep Med Rep. 2017;3(2):48-56. doi: 10.1007/s40675-017-0065-4. Pubblicato online l'8 maggio 2017.
- Lemoine P, Zisapel N; Formulazione a rilascio prolungato di melatonina (Circadin) per il trattamento dell'insonnia. Expert Opin Pharmacother. 2012 Apr;13(6):895-905. doi: 10.1517/14656566.2012.667076. Epub 2012 Mar 19.
- Qaseem A, Kansagara D, Forciea MA, et al; Gestione del Disturbo di Insonnia Cronica negli Adulti: Linee Guida di Pratica Clinica dall'American College of Physicians. Ann Intern Med. 2016 Lug 19;165(2):125-33. doi: 10.7326/M15-2175. Pubblicato online 2016 Mag 3.
- Sateia MJ, Buysse DJ, Krystal AD, et al; Linee guida per la pratica clinica per il trattamento farmacologico dell'insonnia cronica negli adulti: una linea guida per la pratica clinica dell'American Academy of Sleep Medicine. J Clin Sleep Med. 2017 Feb 15;13(2):307-349. doi: 10.5664/jcsm.6470.
- Hale L, Guan S; Tempo davanti allo schermo e sonno tra bambini e adolescenti in età scolare: una revisione sistematica della letteratura. Sleep Med Rev. 2015 Giu;21:50-8. doi: 10.1016/j.smrv.2014.07.007. Pubblicato online 2014 Ago 12.
- Chang AM, Aeschbach D, Duffy JF, et al; L'uso serale di eReader a emissione di luce influisce negativamente sul sonno, sul ritmo circadiano e sulla prontezza al risveglio. Proc Natl Acad Sci U S A. 27 gennaio 2015;112(4):1232-7. doi: 10.1073/pnas.1418490112. Pubblicato online il 22 dicembre 2014.
- Farmaci associati a dipendenza o sintomi di astinenza: prescrizione sicura e gestione dell'astinenza per adulti; Linee guida NICE (aprile 2022)
- Insonnia; NICE CKS, aprile 2024 (accesso solo Regno Unito)
- Diario del Sonno; La Fondazione del Sonno.
Informazioni sull'autoreVisualizza il profilo completo

Dr Colin Tidy, MRCGP
Medico di base, Autore medico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Il Dr Colin Tidy è un medico del NHS, con sede nell'Oxfordshire.
Informazioni sul recensoreVisualizza il profilo completo

Dr Hayley Willacy, FRCGP
Medico di base, Autore medico
MBChB (1992), DRCOG, DFFP, MRCOG (Part 1) MRCGP (2007), DFSRH (2013), MSc - medical education (2020)
La Dott.ssa Hayley Willacy era un medico di base del NHS che lavorava nel nord-ovest dell'Inghilterra, e si è ritirata dalla pratica clinica nel 2022 dopo 30 anni.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 17 Nov 2027
18 Nov 2022 | Ultima versione

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