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Promethazine

Avomine, Phenergan, Sominex

Promethazine is an antihistamine.

You may need to take one or more doses during a day, depending upon the reason you are taking it. Make sure you carefully follow the directions on the label.

Promethazine may affect your ability to drive and to use tools or machines.

The most common side-effects are feeling sleepy, headache, dry mouth and blurred vision.

About promethazine

Tipo di medicinale

An antihistamine

Utilizzato per

Allergic conditions such as hay fever; to prevent sickness (nausea); and as a sedative

Chiamato anche

Avomine®, Vertigon® (promethazine teoclate); Phenergan®, Sominex® (promethazine hydrochloride)

Disponibile come

Compresse, medicina liquida orale e iniezione

Promethazine belongs to a group of medicines known as sedating antistaminici. It has several uses.

It is used to prevent (or treat) feelings of sickness (nausea). It is commonly recommended for sickness associated with travel and for vertigo.

It is also used to relieve allergies such as febbre da fieno e allergic skin rashes.

Promethazine also makes you feel sleepy (has a sedative effect). It may be taken (for a few days only) to help promote sleep in adults with sleeping problems. It has been popular in the past as a means of 'settling' children, but promethazine should not be used in this way.

Promethazine is available on prescription, or you can buy it without a prescription at pharmacies. It is not suitable for children under 2 years of age.

To make sure this is the right treatment for you, before you start taking promethazine it is important that you discuss the treatment with a doctor or pharmacist if:

  • You are pregnant, trying for a baby or breastfeeding.

  • You have a problem with the way your liver works, or if you have a problem with your kidneys.

  • You have a slow or irregular heartbeat.

  • You have a condition which causes increased pressure in your eyes, such as glaucoma.

  • You have prostate problems or if you have been experiencing any difficulty passing urine.

  • You know you have a blockage in your small intestines.

  • You have epilepsy.

  • You have any long-term breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).

  • You have a low level of potassium in your blood (hypokalaemia).

  • Stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

  • You have ever had an allergic reaction to a medicine.

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  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. There are a number of different brands and strengths of promethazine tablet. The manufacturer's leaflet will give you more information about the brand you have been given. It will also contain a full list of the side-effects which you may experience from taking promethazine.

  • Take promethazine exactly as your doctor or pharmacist has told you to. You may be asked to take one or more doses during a day, depending upon the reason why you are taking it.

  • If you are taking promethazine to prevent travel sickness, it is usually recommended that you take the first dose at bedtime on the evening before you are due to travel. You can then take a further dose on the morning of your travel if needed.

  • You can take promethazine before or after meals. Some people find it helps to swallow the tablets with a drink of water.

  • If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child.

  • Most people only need to take an antihistamine for a short while when they have symptoms. You should stop taking promethazine once your symptoms have eased. Do not take promethazine for more than a few days for sleeping problems.

  • Promethazine may cause drowsiness and blurred vision. If this happens to you, do not drive and do not use tools or machines. Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.

  • If you are pregnant, only take promethazine on the advice of your doctor. Do not take promethazine in the last two weeks before your baby is born as it could cause side-effects for your baby.

  • If you are having an operation or any treatment (particularly if it is to test for an allergy), tell the person carrying out the treatment that you are taking promethazine.

  • Promethazine may cause your skin to become more sensitive to sunlight than normal. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.

  • If you buy any medicines, check with a pharmacist that they are safe to take with an antihistamine. This is because a number of other medicines can interfere with the way promethazine works and can increase the risk of side-effects.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with promethazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.

Effetti collaterali comuni

promethazine side-effects

Cosa posso fare se sperimento questo?

Feeling dizzy or sleepy, and blurred vision

Do not drive and do not use tools or machines. Do not drink alcohol

Mal di testa

Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, stop taking promethazine or speak with your doctor

Bocca secca

Try sucking sugar-free sweets or chewing sugar-free gum

Difficulty passing urine

Speak with your doctor if this becomes troublesome

Stomach upset, constipation

Cerca di seguire una dieta equilibrata e bevi molta acqua

Se si verificano altri sintomi che ritieni possano essere dovuti a questo medicinale, parla con il tuo medico o farmacista.

  • Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

  • Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali

Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.

Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.

Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.

Se hai domande su questo medicinale, chiedi al tuo farmacista.

Segnala effetti collaterali di un medicinale o vaccino

Se si verificano effetti collaterali, è possibile segnalarli online tramite il sito web Yellow Card.

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Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • Prossima revisione prevista: 17 Mar 2026
  • 18 Mar 2023 | Ultima versione

    Ultimo aggiornamento di

    Michael Stewart, MRPharmS

    Revisione paritaria di

    Sid Dajani
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