Methadone oral solution
Metharose, Physeptone
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 14 Set 2024
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Questo medicinale è un antidolorifico oppioide. Esiste un serio rischio di dipendenza quando si assume questo medicinale, specialmente se usato a lungo termine. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued nuove linee guida per le persone a cui è stato prescritto un antidolorifico oppioide. Se hai domande o preoccupazioni sull'assunzione sicura di oppioidi, ti preghiamo di parlare con il tuo medico o un farmacista.
Methadone oral solution is a substitute for street drugs like heroin which cause dependence and addiction.
It is important for you to continue to take methadone regularly, every day.
You are more likely to succeed in staying off heroin if you have support. Please ask about what counselling and help are available in your area.
At a glance
Methadone is a medicine used to treat opioid dependence and addiction.
It helps prevent withdrawal symptoms and is usually taken once daily as an oral liquid.
You will be supervised when you first start taking methadone to ensure correct dosage.
Do not drink alcohol or take street drugs with methadone due to increased overdose risk.
Do not stop taking methadone without discussing it with your doctor.
If you suspect an overdose, seek immediate medical help.
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About methadone
Tipo di medicinale | An opioid substitution therapy |
Utilizzato per | To help manage opioid dependence and addiction in adults (such as heroin addiction) |
Chiamato anche | Metharose®, Physeptone® |
Disponibile come | Oral solution, tablets |
Methadone is prescribed to help you keep off droghe da strada such as heroin. It can help to prevent the unpleasant withdrawal symptoms which can occur when you stop using drugs like these. It is taken by mouth as an oral liquid and it works as a substitution treatment. Many people choose to stay on methadone long-term, although some people gradually reduce their dose and come off it.
The effects of methadone last longer than heroin so it is usually prescribed as a once-daily dose. To begin with, you will usually be asked to take it under the supervision of the person who dispenses the methadone to you. This means there can be no doubt about how much methadone you take at each dose. This supervision may be relaxed after a few months of you taking a regular maintenance dose.
Methadone also acts as a painkiller. It is occasionally used to treat severe pain if other strong painkillers are unsuitable. If you have been prescribed methadone for this reason then you should speak with your doctor or home-care team if you have any questions about your treatment. This document gives information about methadone when it is used to manage drug addiction only.
Before taking methadone
Torna ai contenutiTo make sure that this is the right treatment for you, before you start taking methadone it is important that your doctor or pharmacist knows:
Se sei incinta o stai allattando.
Se hai problemi alla prostata o difficoltà a urinare.
Se hai problemi respiratori, come l'asma o la broncopneumopatia cronica ostruttiva (BPCO).
If you have been told you have low blood pressure or an unusual heart rhythm.
Se hai problemi con la tiroide o le ghiandole surrenali.
If you have fits or epilepsy.
If you have a problem with the way your liver works or a problem with the way your kidneys work.
Se hai un problema con il tuo dotto biliare.
Se sei stato stitico per più di una settimana o hai un problema infiammatorio intestinale.
Se hai una condizione che causa debolezza muscolare, chiamata miastenia grave.
Se hai avuto di recente una grave lesione alla testa.
Se hai mai avuto una reazione allergica a un medicinale.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
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How to take methadone
Torna ai contenutiCarefully follow the advice your doctor has given to you and read any printed information you have been given. The manufacturer's printed information leaflet (which will be supplied with the medicine) will give you more information about methadone and will provide you with a full list of the side-effects which you could experience from taking it.
Take methadone exactly as your doctor tells you to. Do not take more, or less, than the dose you have been prescribed. It is usually prescribed as a once-daily dose
Try to take your dose at the same time of day, each day. Initially you will be asked to take methadone where you can be supervised. This is to help you stick with your treatment and make sure you do not miss any doses.
At first your doctor will prescribe a low-ish dose and then see you frequently to adjust this to a regular maintenance dose. This early stage is very important because too high a dose can cause you serious harm, so please be patient. It may take a few weeks until the correct dose is found and you may have some minor withdrawal symptoms during this time. The correct dose varies from person to person, depending on how much heroin you were using and how your body deals with (metabolises) methadone.
If you miss a dose, wait until it is time for your next dose and take this next dose when it is due. Do fare affidamento take two doses together to make up for a missed dose. It is important that you tell your doctor you have missed a dose. If you miss more than three days of methadone, your dose will need to be changed.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiIt is important that you keep your regular appointments with your doctor/clinic so that your progress can be reviewed. You will be asked to give a urine sample from time to time.
You are more likely to succeed in staying off heroin if you have support and counselling. Local drug community teams, self-help groups and other agencies can be of help. It is much harder to 'do it alone', so go for counselling and help if it is available in your area.
Methadone causes drowsiness and will affect your ability to drive. It is against the law to drive if your driving ability is impaired by this medicine. Even if your driving is not impaired, you will be guilty of an offence unless the methadone has been prescribed for a medical reason e it has been taken according to the instructions given by the prescriber.
Do not take more than the dose your doctor has prescribed for you. Signs of overdose can include pinpoint pupils, shallow breathing and, eventually, unconsciousness. If you suspect that you or someone else might have had an overdose of methadone, contact a doctor or go to the accident and emergency department of a local hospital straightaway. Take the container with you, even if it is empty.
You should not take any street drugs or drink alcohol while you are on methadone. This is because other street drugs and/or alcohol can increase the risk of overdose and side-effects.
Methadone (even in small amounts) is a special hazard to children and other people if it is swallowed by accident. If you suspect that someone else has swallowed some methadone, please get medical help straightaway.
Do not stop taking methadone without discussing this with your doctor or drug-team worker first. It is important that methadone should be taken regularly to reduce the risk of withdrawal symptoms from occurring. Withdrawal symptoms from methadone are similar to those from heroin (they are less severe but last longer). When you are ready to consider becoming drug-free, your doctor or drug-team worker will be able to help you decide on the best way to do this in order to keep withdrawal effects to a minimum.
If you buy any medicines, please check with a pharmacist that they are safe to take with methadone.
If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking methadone. It could interfere with an anaesthetic, if needed.
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Can methadone cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with methadone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common methadone side-effects | Cosa posso fare se sperimento questo? |
Sensazione di malessere (nausea) o vomito, dolore addominale | Attieniti a pasti semplici - evita cibi ricchi o piccanti |
Costipazione | Segui una dieta equilibrata e bevi molta acqua ogni giorno |
Feeling dizzy, faint or sleepy | Non guidare e non utilizzare strumenti o macchinari. Non bere alcolici |
Bocca secca | Prova a masticare gomme senza zucchero o a succhiare caramelle senza zucchero |
Other effects include: difficulty passing urine, mood changes, flushing, hypothermia, slow heartbeat, dry eyes and feeling restless | If any of these become particularly troublesome, speak with your doctor |
Importante: le persone che assumono analgesici oppioidi, e i loro familiari e amici, dovrebbero essere consapevoli del rischio di overdose accidentale e sapere quando chiedere aiuto medico. Il rischio è maggiore se si assumono anche altri farmaci che causano sonnolenza. I segnali di aver assunto troppo farmaco includono:
Sensazione di molta sonnolenza o vertigini.
Sensazione di malessere (nausea) o vomito.
Difficoltà respiratorie.
Perdita di coscienza.
Se hai assunto più farmaci del previsto o qualcun altro ha accidentalmente ingerito il tuo medicinale, chiama un'ambulanza e comunica loro il nome del tuo farmaco.
If you experience any other symptoms which you think may be due to methadone, please speak with your doctor, clinic or pharmacist for further advice.
How to store methadone
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Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
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Domande frequenti
How does methadone help stop heroin withdrawal symptoms?
Methadone is prescribed to help manage opioid dependence and addiction by preventing the unpleasant withdrawal symptoms that can occur when you stop using drugs like heroin. It works as a substitution treatment and its effects last longer than heroin, so it is usually taken once daily.
Why is methadone supervision necessary, and will it always be required?
Initially, you will usually be asked to take methadone under supervision, meaning someone will dispense it to you. This is to ensure the correct dose is taken and to help you stick with your treatment. This supervision may be relaxed after a few months once you are on a regular maintenance dose.
What should I do if I miss a dose of methadone?
If you miss a dose, you should wait until it's time for your next scheduled dose and take that dose as usual. Do not take two doses together to compensate for the missed one. It's important to tell your doctor if you miss a dose. If you miss more than three days of methadone, your dose will need to be adjusted by your doctor.
Can I drive while taking methadone?
Methadone can cause drowsiness and will affect your ability to drive. It is against the law to drive if this medicine impairs your driving ability. Even if your driving is not impaired, you could be committing an offence unless the methadone has been prescribed for a medical reason and you have taken it according to your prescriber's instructions.
What are the risks of taking other street drugs or alcohol with methadone?
You should not take any street drugs or drink alcohol while on methadone. Doing so can increase the risk of overdose and worsen side-effects. Always avoid mixing methadone with other substances.
What should I do if someone accidentally swallows my methadone?
Methadone, even in small amounts, poses a significant hazard if swallowed by children or other people. If you suspect that someone else has swallowed methadone, you must get medical help straightaway.
What if I experience side-effects like feeling sick, constipation, or dizziness?
Many common side-effects improve as your body adjusts to methadone. If you feel sick or are being sick, try to stick to simple meals and avoid rich or spicy foods. For constipation, eat a well-balanced diet and drink plenty of water. If you feel dizzy, faint, or sleepy, do not drive or operate machinery, and avoid alcohol. If any side-effects continue or become troublesome, speak with your doctor or pharmacist.
How long will it take to find the correct dose of methadone for me?
Initially, your doctor will prescribe a low dose and will see you frequently to adjust it to a regular maintenance dose. This early stage is crucial because too high a dose can be dangerous. It may take a few weeks until the correct dose is found, and you might experience some minor withdrawal symptoms during this period. The correct dose is unique to each person, depending on their previous heroin use and how their body processes methadone.
What should I do if I need an operation or dental treatment while on methadone?
If you are having an operation or dental treatment, it is very important to tell the person carrying out the treatment that you are taking methadone. This is because methadone could interfere with an anaesthetic if one is needed.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Methadone 1 mg/ml Oral Solution BP - Sugar Free; Martindale Pharma Ltd, The electronic Medicines Compendium. Dated May 2023.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Prossima revisione prevista: 12 Set 2027
14 Set 2024 | Ultima versione

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