Compresse di vareniclina
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 15 Gen 2025
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A combination of varenicline with counselling can increase your chance of successfully stopping smoking.
Start taking the tablets at least a week before your target stop date.
Tell your doctor if you develop any side-effects. The most commonly reported side-effects are feeling sick, problems sleeping, headache, and nose and throat infections.
A colpo d'occhio
Varenicline (Champix®) is a medicine used to help people stop smoking.
It can reduce the urge to smoke and relieve withdrawal symptoms.
You take varenicline for at least a week before your quit date.
A full course of treatment usually lasts for 12 weeks.
Common side effects include headache, nausea, and disturbed sleep.
If you become agitated or depressed, or have thoughts of harming yourself, stop taking varenicline and tell your doctor straightaway.
About varenicline
Tipo di medicinale | A smoking cessation aid - a selective nicotine-receptor partial agonist |
Utilizzato per | Helping people to stop smoking |
Chiamato anche | Champix® |
Disponibile come | Compresse |
Nicotine is a drug that is inhaled from the tobacco in cigarettes. It gets into the bloodstream and stimulates the brain. Most regular smokers are addicted to nicotine. Even though you want to smettere di fumare, it can be difficult to succeed, because nicotine addiction is strong and hard to break. This is where varenicline can help.
Varenicline mimics the effect of nicotine on the body. This both reduces the urge to smoke and relieves withdrawal symptoms. It also blunts the effect of nicotine in people who give in to temptation and have a cigarette. This reduces the enjoyment of smoking.
Varenicline will not make you stop smoking. You will still need determination to succeed and to break the smoking habit. A combination of varenicline with counselling from a nurse, doctor, pharmacist, or other health professional is likely to increase your chance of successfully stopping smoking. Therefore, most doctors will only prescribe varenicline to people who really want to stop smoking as part of a stopping smoking programme.
Before taking varenicline
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking varenicline it is important that your doctor knows:
Se sei incinta, stai cercando di avere un bambino o stai allattando.
Se hai meno di 18 anni.
If you have ever had a mental health problem such as depression.
If you have ever had a heart or blood vessel problem.
Se hai un problema con il funzionamento dei tuoi reni.
If for any reason you are at risk of having a seizure.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
How to take varenicline
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about varenicline and stopping smoking. It will also provide you with a full list of the side-effects which can be associated with varenicline.
Take varenicline exactly as your doctor tells you to. You will be asked to set yourself a date on which to stop smoking. Your doctor will then ask you to start taking varenicline tablets at least a week before this 'quit' date. The aim is to build up the dose so that your body gets used to the medicine before your quit date.
Start by taking one white tablet (500 microgram) once daily for the first three days. Then on days four to seven, take one white tablet twice a day, one in the morning and one in the evening. On day eight onwards, take one light blue tablet (1 mg) twice a day. A full course of treatment lasts for 12 weeks in total. The course may be continued for a further 12 weeks if you have successfully stopped smoking but your doctor feels it will be of help to you.
It is not important whether you take varenicline tablets before or after food, but it is best if you try to take your doses at the same time(s) each day. This will help you to remember to take the tablets regularly. Take each dose with a glass of water - do not chew or break the tablets before you swallow.
If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose (in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Try to keep your regular appointments with your doctor or nurse. This is so that you can be given counselling and encouragement, and also so that a check can be kept on your progress.
Make sure that your doctor or healthcare professional knows if you are taking any other medicines. This is because stopping smoking can change the way your body breaks down certain medicines. So, as a result of quitting, the dose of some prescribed medicines may need to be adjusted.
After your course of treatment, your doctor may suggest that you gradually reduce the dose over a week or so, before you finally stop taking varenicline. This is because a few people have experienced problems for a short time when they have stopped taking varenicline suddenly - these have included an urge to smoke again, feeling depressed or irritable, and sleeping difficulties. Although this only occurs in a small percentage of people, reducing the dose slowly reduces the risk of it happening.
Can varenicline cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with varenicline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. You should tell your doctor if you develop any unwanted effects, as a reduction in dose may be an option for you. Some of the symptoms may also occur as a result of stopping smoking.
Most common varenicline side-effects | Cosa posso fare se sperimento questo? |
Mal di testa, altri dolori o fastidi | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the pains continue, let your doctor know |
Feeling sick (nausea) or being sick (vomiting), stomach upset, indigestion | Keep to simple foods. Try taking the tablets after meals |
Sensazione di sonnolenza o vertigini | Do not drive or use tools or machines until you feel better |
Disturbed sleep, unusual dreams | Try to avoid taking your last dose near to bedtime |
Bocca secca | Prova a masticare gomme senza zucchero o a succhiare caramelle senza zucchero |
Nose and throat infections, change in appetite, increased weight, changes in the way things taste, feeling short of breath, cough, itchy rash | Se problematico, parla con il tuo medico |
Importante: if you become agitated or depressed, or if you start having thoughts about harming yourself, you must stop taking varenicline and let your doctor know immediatamente. These symptoms can occasionally occur as a side-effect of treatment, and they can also occur as a result of nicotine withdrawal.
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.
How to store varenicline
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Se acquisti dei medicinali, verifica sempre con un farmacista che siano sicuri da assumere insieme agli altri tuoi medicinali.
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
This medicine is for you. Do not give it to others, even if their condition appears to be the same as yours.
If you are having any medical treatment, tell the person carrying out the treatment which medicines you are taking.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
If you have any questions about your medicines, ask your pharmacist.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Sito web Yellow Card.

Non sei sicuro di mescolare i medicinali?
Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.
Domande frequenti
What specifically does varenicline do within the brain to help stop smoking?
Varenicline works by mimicking the effect of nicotine in the brain. This action helps to reduce the intense urge to smoke and alleviates the uncomfortable withdrawal symptoms that often occur when someone tries to quit. Additionally, if you do smoke a cigarette while taking varenicline, it blunts nicotine's effect, making smoking less enjoyable.
Are there any specific concerns for people with high blood pressure when considering varenicline?
The article mentions that it's important for your doctor to know 'If you have ever had a heart or blood vessel problem' before you start taking varenicline. While high blood pressure isn't explicitly listed, it is a significant factor related to heart and blood vessel health, so you should definitely discuss any history of high blood pressure with your doctor.
Can varenicline be taken alongside other medications, including over-the-counter ones?
Yes, it's crucial to inform your doctor about all other medicines you are taking. This includes any medicines bought without a prescription, as well as herbal and complementary medicines. This is because stopping smoking can alter how your body processes certain medicines, potentially requiring adjustments to the doses of some prescribed medications.
What are the common reasons people might need to gradually reduce their varenicline dose instead of stopping suddenly?
After completing your full course of treatment, your doctor might suggest gradually reducing the dose over about a week. This is because some individuals have reported experiencing temporary issues after suddenly stopping varenicline. These issues can include a renewed urge to smoke, feelings of depression or irritability, and difficulties with sleep. A gradual reduction helps to minimise these risks.
What should I do if I accidentally take more varenicline than prescribed?
If you suspect that you or someone else might have taken an overdose of varenicline, you should immediately go to the accident and emergency department of your local hospital. It's important to take the medicine container with you, even if it's empty, to provide medical staff with information about the medication.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Champix® 0.5 mg and 1 mg film-coated tablets; Pfizer Limited, The electronic Medicines Compendium. Dated October 2023.
- Manufacturer's PIL, Varenicline 0.5 mg and 1 mg film-coated tablets; Brown & Burk UK Ltd, The electronic Medicines Compendium. Dated April 2024.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 14 Gen 2028
15 Gen 2025 | Ultima versione

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