Doxycycline tablets and capsules
Periostat, Vibramycin-D
Revisione paritaria di Dr Colin Tidy, MRCGPUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 5 May 2025
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Take doxycycline with plenty of water. Stand or sit up to take your doses - this will stop the capsules/tablets from causing any irritation to your throat.
Make sure you continue to take the medicine until you finish the full course prescribed.
Do not take indigestion remedies, or supplements containing iron, magnesium, or zinc at the same time as doxycycline as they stop it from working properly.
The most common side effects of doxycycline are diarrhoea, upset stomach, stomach pain, and headache.
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About doxycycline
Tipo di medicinale | Un antibiotico tetraciclinico |
Utilizzato per | Bacterial infections; to prevent malaria. |
Chiamato anche (UK) | Efracea®, Periostat®, Vibramycin-D® |
Chiamato anche (USA) | Acticlate®, Doryx®, Mondoxyne®, Monodox®, Okebo®, Oracea®, Targadox®, Vibramycin® |
Disponibile come | Capsules, modified-release capsules, dispersible tablets; oral liquid medicine (USA) |
What is doxycycline used for?
Torna ai contenutiDoxycycline is a type of antibiotic that is used to treat a number of different types of infection, including chest infections, some skin conditions, infezioni sessualmente trasmissibili, and infections in or around the mouth.
Doxycycline is also used to prevent people from getting malaria when they travel to countries where malaria occurs.
Although doxycycline can only be obtained on a prescription from a doctor, it is not prescribable on the NHS to prevent malaria. This means that you will be given a private (non-NHS) prescription and you will be asked to pay the full price for the tablets/capsules if you are taking it for this reason.
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Doxycycline side effects
Torna ai contenutiCommon side effects of doxycycline are:
Upset stomach.
Indigestione.
Dolore addominale.
Diarrea.
Mal di testa.
Dolori e dolenzia.
Yeast infection (thrush).
Bocca secca.
Ansia.
Increased sweating.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of these side effects continue or become troublesome.
How to manage doxycycline side effects
Torna ai contenutiDoxycycline side effects | Cosa posso fare se sperimento questo? |
Stomach upset, indigestion, tummy pain | Stick to simple foods - avoid fatty or spicy meals. Take your doses after a meal or with a snack |
Diarrea | Bevi molta acqua per reintegrare i liquidi persi. Se questo continua o è grave, consulta un medico |
Headache, other aches and pains | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know |
A yeast infection which causes redness and itchiness in the mouth or vagina | Speak with a doctor or pharmacist for advice |
Dry mouth, throat irritation | Remember to take your doses with a large glass of water while you are standing or sitting upright |
Feeling anxious, increased sweating | If troublesome, speak with a doctor |
Importante: doxycycline can occasionally cause allergic reactions, such as a skin rash, swollen lips or tongue and difficulty breathing. Seek medical attention as soon as possible if this happens to you.
Remember that doxycycline may make your skin more sensitive to sunlight than usual, causing rash-like symptoms. Use a sun cream with a high sun protection factor on bright days and use a moisturiser to soothe irritated skin.
In rare cases, treatment with tetracycline antibiotics can cause an increase in blood pressure inside the skull. This can cause symptoms such as headache, being sick (vomiting) and vision problems such as blurred or double vision or loss of vision. If this happens to you, seek medical attention and do not take any more of this medicine.
If you experience any other symptoms which you think may be due to the medicine, discuss them with your doctor or pharmacist who will be able to advise you further.
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Who should not take doxycycline?
Torna ai contenutiSome medicines are not suitable for people with certain conditions. Before starting doxycycline it is important that your doctor or pharmacist knows:
Se sei incinta, stai cercando di avere un bambino o stai allattando.
Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.
If you have an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE).
Se hai una condizione che causa debolezza muscolare, chiamata miastenia grave.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
How to take doxycycline
Torna ai contenutiRead the leaflet in the pack before starting doxycycline. It explains how to take it and lists possible side effects.
Take doxycycline exactly as your doctor tells you. It is usually one dose a day however some people will be prescribed two. For mouth ulcers you may be asked to take four doses a day.
If taking capsules, you must swallow these whole with a glass of water during mealtime. Sit or stand while taking it, and do not take right before bed to avoid throat irritation.
If you have been given dispersible tablets (Vibramycin-D®), you should stir these into a small glass of water to take them. Rinse the solution around your mouth for 2-3 minutes, and then spit it out.
Se dimentichi di prendere una dose, prendila appena te ne ricordi. Cerca di assumere il numero corretto di dosi ogni giorno, ma non prendere due dosi contemporaneamente per compensare una dose dimenticata.
Depending on what you are being treated for, your course of treatment could last from a week, to several months. Keep taking doxycycline until the course is finished unless you are told to stop sooner by a doctor.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiAvoid taking antacids or supplements with iron, magnesium, or zinc within 2 hours before or after doxycycline, as they can make it less effective.
Doxycycline may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds. Use a sun cream with a high sun protection factor on bright days, even when it is cloudy.
This antibiotic may stop the oral vaccino orale contro il tifo from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
You will be prescribed a brand of doxycycline that is appropriate for your need, as not all brands are suitable for all of these indications.
Information for protection against malaria
If you are taking doxycycline to protect against malaria, you must start taking it 1-2 days before you travel. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. You should continue to take it throughout your stay and for a further four weeks after you have left the area.
If you feel ill or develop a high temperature (fever) or flu-like symptoms while you are travelling or within one year (especially if it is within three months) of returning home, you should see your doctor straightaway. This is important, even if you have taken your antimalarial tablets correctly.
Doxycycline will help reduce the risk of you getting malaria, but it is also important that you take the following precautions against being bitten by mosquitoes:
Cover up bare areas of your arms and legs with long-sleeved, loose-fitting clothing, long trousers and socks. This is especially important if you are outside after sunset, as this is when mosquitoes feed.
Use an effective insect repellent spray on your clothing and any area of your skin which is bare. If you are also using a sunscreen, apply the sunscreen first and the insect repellent afterwards.
Spray the room with an insecticide each evening a couple of hours before you go to bed. Check your sleeping areas for mosquitoes - pay particular attention to furniture and areas under your bed where insects can hide.
If you are sleeping in an unscreened room, use a mosquito net impregnated with an insecticide.
How to store doxycycline
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Se devi sottoporti a un'operazione o a un trattamento dentale, informa la persona che esegue il trattamento sui medicinali che stai assumendo.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il sito web Yellow Card.
Domande frequenti
Torna ai contenutiHow long does doxycycline take to work?
Doxycycline usually starts working within 24 to 48 hours. Most people notice improvement in their symptoms after 2 to 3 days, but you should keep taking the medicine for the full course prescribed, even if you feel better.
Can you drink alcohol with doxycycline?
Yes, you can drink alcohol in moderation while taking doxycycline as alcohol does not stop doxycycline from working. However, drinking too much can increase side effects such as upset stomach, dizziness, or dehydration. For best results limit your alcohol intake until you finish your course.
Is doxycycline safe to take during pregnancy?
No, doxycycline is generally not safe to take during pregnancy. It can affect the development of a baby’s bones and teeth, especially in the second and third trimesters. Always let your doctor know if you are pregnant or planning to become pregnant so you can be prescribed a safer antibiotic.
Does doxycycline make you tired?
Doxycycline can make some people feel tired but it is not a common side effect. If tiredness is severe or doesn't go away, speak to your doctor.
How long does doxycycline stay in your system?
Doxycycline has a half-life of about 18-22 hours, which means it takes roughly 1-2 days for most of it to leave your system after your last dose. However, trace amounts can stay for a few days longer. It is usually fully cleared within 5 days.

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Ulteriori letture e riferimenti
- Manufacturer's PIL, Doxycycline 50 mg and 100 mg capsules; Sovereign Medical, The electronic Medicines Compendium. Dated March 2024.
- Manufacturer's PIL, Vibramycin-D Dispersible Tablets 100 mg; Pfizer Ltd, The electronic Medicines Compendium. Dated December 2023.
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Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 5 May 2028
5 May 2025 | Ultima versione

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