Salta al contenuto principale

Can I take Aspirin and Diclofenac together?

Guida alle interazioni farmacologiche

Taking aspirin and diclofenac together significantly increases your risk of developing stomach ulcers, internal bleeding, and kidney problems. Both medicines belong to the same family (NSAIDs), and using them together 'doubles up' the risk of side effects without providing much extra pain relief.

You should not take aspirina e diclofenac together unless specifically instructed by your doctor.

Both drugs work by blocking enzymes (COX-1 and COX-2) that protect the lining of your stomach and keep your kidneys working properly.

When you take both, the protective layer in your stomach is weakened further, and blood flow to the kidneys can be reduced. Additionally, both drugs thin the blood, making any bleeding more difficult to stop.

If you must take both, your doctor may prescribe a 'stomach protector' medicine (such as omeprazolo).

If you are taking aspirina a basso dosaggio for heart protection, speak to your GP or pharmacist before using diclofenac, as diclofenac can interfere with aspirin's heart-protective benefits and increase your risk of a stomach bleed.

How to know if you're having a drug interaction?

You may be experiencing an interaction between aspirin and diclofenac if you have:

  • Stomach pain, indigestion, or heartburn.

  • Nausea or vomiting.

  • Black, tarry stools or blood in your stools.

  • Vomiting blood.

  • Unusual bruising or bleeding.

  • Dizziness or headaches.

  • Swelling of the ankles or feet.

  • Shortness of breath or chest pain (rare but serious).

Se hai uno dei sintomi sopra elencati, dovresti:

  • Stop taking the medicines and contact your GP or pharmacist if you develop stomach pain, indigestion, nausea, unusual bruising or mild bleeding.

  • Seek urgent medical help (call 999 / go to A&E) if you have:

    • Black, tarry poo.

    • Vomit (sick) that looks like blood or coffee grounds.

    • Severe stomach pain.

    • Chest pain or shortness of breath.

    • Signs of an allergic reaction (swelling of face/lips, difficulty breathing).

Do not restart either medicine until you have spoken to a healthcare professional.

Continua a leggere sotto

Asma

Do not take these medicines if you have asthma and have ever had a flare-up or breathing difficulties triggered by aspirin or other NSAIDs. This can cause a life-threatening allergic reaction or severe asthma attack.

Stomach ulcers or bleeding

Avoid these medicines if you have a history of stomach ulcers or gastrointestinal bleeding. They significantly increase the risk of serious stomach damage and internal bleeding.

Pregnancy (third trimester)

Do not take these medicines if you are more than 20 weeks pregnant. They can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Alcol

Drinking alcohol while taking these medicines increases the risk of irritation and bleeding in your stomach and intestines. It is best to avoid or limit alcohol consumption.

Caffeina (caffè, tè, bevande energetiche)

Aspirin can increase the effects of caffeine, potentially leading to jitteriness, a racing heart, or difficulty sleeping. Additionally, both caffeine and aspirin can irritate the stomach lining, increasing the risk of indigestion or ulcers when combined.

Continua a leggere sotto

Assumi più farmaci? Il nostro Controllo Interazioni Farmaci ti aiuta a verificare se le tue prescrizioni, i farmaci da banco e gli integratori sono sicuri da assumere insieme. Basta cercare i tuoi farmaci per vedere le potenziali interazioni e cosa fare al riguardo.

Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.

Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • 25 Gen 2026 | Pubblicato originariamente
flu eligibility checker

Chiedi, condividi, connettiti.

Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.

symptom checker

Non ti senti bene?

Valuta i tuoi sintomi online gratuitamente

Iscriviti alla newsletter di Patient

La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.

Per favore, inserisci un indirizzo email valido

Abbonandoti accetti il nostro Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.