Zafirlukast per l'asma
Accolate
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 3 Sept 2024
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Nota dell'autore clinico
Michael Stewart 12/9/2018: Accolate® tablets were discontinued in the UK in March 2018. At the time of review there are no branded or generic products containing zafirlukast available in the UK. Zafirlukast may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Take zafirlukast twice daily, one tablet in the morning and one in the evening.
Your doctor will prescribe a reliever inhaler for you to use in case you have an asthma attack. Make sure that you keep it with you all the time.
The most common side-effects are high temperature (fever) and frequent sore throats and infections.
A colpo d'occhio
Zafirlukast is a medicine used to treat asthma in adults and children over 12 years old.
It helps control asthma symptoms by blocking chemicals called leukotrienes in the body.
Take one tablet in the morning and one in the evening, on an empty stomach.
Zafirlukast will not provide immediate relief during an asthma attack; use your reliever inhaler for this.
Contact your doctor if your asthma symptoms worsen or if you need your reliever inhaler more often.
Possible side-effects include fever, sore throat, headache, and tummy upset.
Seek medical advice immediately if you experience yellow skin or eyes, or flu-like symptoms with tingling.
About zafirlukast
Tipo di medicinale | A leukotriene receptor antagonist |
Utilizzato per | Asthma (for adults and for children aged over 12 years) |
Chiamato anche | Accolate® (discontinued in UK) |
Disponibile come | Compresse |
Asma is a common condition caused by inflammation in the smaller airways of the lungs. The inflammation irritates the muscles around the airways and causes them to constrict. This causes your airways to narrow. It is then more difficult for air to get in and out of your lungs. This causes the typical symptoms of wheeze, chest tightness and shortness of breath. The inflammation also causes the lining of your airways to make extra mucus which causes coughing.
Asthma symptoms can flare up from time to time and there may be no apparent reason why. However, some people find that symptoms are made worse by triggers such as exercise and pollen. These things cause your body to produce chemical substances called leukotrienes, which cause the inflammation. Zafirlukast helps control the symptoms of asthma by blocking the effects of these leukotrienes.
Before taking zafirlukast
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking zafirlukast it is important that your doctor knows:
Se sei incinta, stai cercando di avere un bambino o stai allattando.
Se hai problemi con il funzionamento del tuo fegato, o problemi con il funzionamento dei tuoi reni.
Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
How to take zafirlukast
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about zafirlukast and will provide you with a full list of the side-effects which you could experience from taking it.
Take zafirlukast exactly as your doctor tells you to. The usual dose is one tablet in the morning and one in the evening.
Swallow the tablet with a drink of water. You should take it 'on an empty stomach', which means that you should take the tablet about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less zafirlukast after a meal, which means the medicine is less effective.
Take zafirlukast regularly every day, even if your asthma is well controlled. Try not to miss any of your doses but if you do forget, take it as soon as you remember. If when you remember, it is almost time to take your next dose then skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, your doctor may want you to have blood tests from time to time to check on the way your liver is working.
Zafirlukast will not give you immediate relief if you are having an asthma attack. Your doctor will prescribe a reliever inhaler for you to use if this happens. Make sure that you keep it with you all the time in case you need to use it.
If you find that your asthma symptoms are getting worse, or that you need to use the reliever inhaler more regularly than usual, please contact your doctor or nurse for advice straightaway.
Do not smoke. Smoking causes severe irritation and damage to the lungs. It will make your condition worse and will reduce the beneficial effects of your medication.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. Some anti-inflammatory painkillers and aspirin can make asthma symptoms worse in some people.
Can zafirlukast cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with zafirlukast. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common zafirlukast side-effects (these affect more than 1 in 10 people) | Cosa posso fare se sperimento questo? |
High temperature (fever), sore throat and chest infections | Se problematico, parla con il tuo medico |
Common zafirlukast side-effects (these affect fewer than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Sensazione di malessere (nausea) o vomito, dolore addominale | Stick to simple meals and drink plenty of water. Speak with your doctor if this continues |
Mal di testa, dolori muscolari e dolori | Ask your pharmacist to recommend a suitable painkiller if troublesome |
Importante: if you get any of the following symptoms, you should let your doctor know straightaway so that you can have a check-up:
Constantly feeling or being sick, stomach pain, yellowing of your skin or the whites of your eyes (jaundice) and feeling generally unwell. These can be signs of a problem with your liver.
Flu-like symptoms, tingling feelings or numbness in your arms or legs, difficulties with breathing, and skin rash. These can be a sign of a very rare but serious disorder called Churg-Strauss syndrome.
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, ti preghiamo di consultare il tuo medico o farmacista per ulteriori consigli.
How to store zafirlukast
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Never take more than the prescribed dose. If you suspect that you or someone else might have had an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Se devi sottoporti a un'operazione o a un trattamento dentale, informa la persona che esegue il trattamento sui medicinali che stai assumendo.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
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Domande frequenti
Can I take zafirlukast with other asthma medications?
The article mentions that zafirlukast will not provide immediate relief for asthma attacks and that a reliever inhaler will be prescribed for such situations. It also advises checking with your pharmacist about taking other medicines, including over-the-counter and herbal remedies, to ensure they are suitable with zafirlukast.
Does zafirlukast treat asthma or just its symptoms?
Zafirlukast works by blocking the effects of leukotrienes, which are chemical substances in the body that cause inflammation in the airways. By doing this, it helps to control the symptoms of asthma, such as wheezing, chest tightness, and shortness of breath.
How long will it take for zafirlukast to start working?
The article states that zafirlukast will not give immediate relief if you are having an asthma attack. It implies it is a regular, preventative medication rather than a fast-acting one, but does not specify a timeframe for when its regular symptom control effects will become noticeable.
What should I do if I accidentally take more than the prescribed dose of zafirlukast?
If you suspect that you or someone else might have had an overdose of zafirlukast, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Is zafirlukast safe to use during pregnancy or while breastfeeding?
Before starting zafirlukast treatment, it is important to inform your doctor if you are pregnant, trying for a baby, or breastfeeding. Your doctor will need to consider this information to determine if zafirlukast is suitable for you.
Ulteriori letture e riferimenti
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Next review due: 3 Sept 2027
3 Sept 2024 | Ultima versione

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