Meperidina per il sollievo dal dolore
Demerol
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 27 Feb 2023
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This medicine is a strong opioid painkiller (narcotic analgesic). There is a serious risk of addiction when taking this medicine, especially if used long-term. If you have any questions or concerns about taking opioids safely please speak with your physician or a pharmacist.
Meperidine is used to relieve pain, particularly during childbirth.
Di solito viene somministrato tramite iniezione e fornisce sollievo dal dolore per un massimo di quattro ore.
The most common side-effects are feeling dizzy or sleepy, sweating and nausea.
A colpo d'occhio
Meperidine is a strong opioid painkiller also known as pethidine.
It is used for severe pain and can be given as tablets, liquid, or injection.
It is commonly used during childbirth because its effects are shorter-lasting.
Do not drink alcohol or drive after taking meperidine.
Tell your doctor about existing conditions or other medicines you are taking.
Repeated use can lead to dependence.
Common side-effects include nausea, dizziness, constipation, and headache.
About meperidine
Tipo di medicinale | A strong opioid painkiller (narcotic analgesic) |
Utilizzato per | Alleviare il dolore |
Chiamato anche | Demerol® |
Disponibile come | Compresse, medicina liquida orale e iniezione |
Oppioidi forti (narcotic analgesics) are medicines used to treat severe pain. Although there are a number of narcotic analgesics, meperidine (also known as pethidine) is the one that has been traditionally used during parto, as its effects are shorter-lasting than some of the others. It works on your nervous system and brain to reduce the amount of pain you feel. Meperidine can be taken by mouth as a tablet or liquid medicine, but during childbirth it is more usually given as an injection.
Before having meperidine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meperidine it is important that your physician knows:
If you are pregnant (other than during labor) or breastfeeding.
Se hai problemi al fegato o ai reni.
Se hai problemi alla prostata o difficoltà a urinare.
Se hai problemi respiratori, come l'asma o la broncopneumopatia cronica ostruttiva (BPCO).
If you have been told you have low blood pressure (hypotension).
Se hai problemi con la tiroide o le ghiandole surrenali.
Se hai l'epilessia.
Se hai un problema con il tuo dotto biliare.
Se sei stato stitico per più di una settimana o hai un problema infiammatorio intestinale.
Se hai una condizione che causa debolezza muscolare, chiamata miastenia grave.
Se hai avuto di recente una grave lesione alla testa.
Se sei mai stato dipendente da droghe o alcol.
Se hai mai avuto una reazione allergica a un medicinale.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
How meperidine is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about meperidine and will provide you with a full list of the side-effects which you may experience from having it.
If you have been prescribed meperidine injection, this will be given to you by your physician or nurse. It will be injected under your skin or into a muscle. The injections can be repeated every few hours during labor, if needed. If you are being given meperidine for other types of pain (such as after surgery), the injection can be repeated every three to four hours.
If you have been prescribed meperidine tablets, take the tablets exactly as your physician has told you to. The usual dose of meperidine is between one and three 50 mg tablets.
If you have been prescribed meperidine oral liquid medicine, take the liquid exactly as your physician tells you to. Use a measuring cup or oral syringe to measure the correct amount of liquid. The measured dose should be mixed in half a glass of water before swallowing. This is because swallowing undiluted meperidine liquid can numb the mouth.
When taking meperidine by mouth, the dose should not be repeated more frequently than every three to four hours.
If you forget to take a dose, take it as soon as you remember and then continue taking your doses every three to four hours from that point. Do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Ask your physician for advice before drinking alcohol. Your physician may recommend that you do not drink alcohol for a while after you have had meperidine because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that meperidine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, you are advised to carry with you some evidence that the medicine has been prescribed for you - a prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are planning a trip abroad and need to take meperidine with you, you are advised to carry a letter with you from your physician to explain why you have been prescribed it. This is because meperidine is classed as a 'controlled drug' and is subject to certain restrictions.
You will not be given meperidine tablets or liquid for longer than is necessary. This is because repeatedly using meperidine over a period of time can lead to your body becoming dependent on it. When you then stop taking it, it will cause withdrawal symptoms such as restlessness and irritability. If you are concerned about this, discuss it with your physician or pharmacist. This will not become a problem if you are receiving a dose or two of meperidine during labor.
Can meperidine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with meperidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common meperidine side-effects | Cosa posso fare se sperimento questo? |
Nausea o vomito | Attieniti a cibi semplici. Bevi molta acqua per reintegrare i liquidi persi |
Sensazione di vertigini, sonnolenza o stordimento | Se ciò accade, non guidare e non utilizzare strumenti o macchinari. Non bere alcolici |
Other common side-effects include headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, feeling confused, difficulties passing urine, shallow breathing | If any of these occur, speak with your physician |
Se si verificano altri sintomi che ritieni possano essere dovuti a questo medicinale, parla con il tuo medico o farmacista.
How to store meperidine
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro abbiate assunto una dose eccessiva di questo medicinale, recati al Pronto Soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Se devi sottoporti a un intervento chirurgico o a qualsiasi trattamento dentistico, informa la persona che esegue il trattamento sui farmaci che stai assumendo.
Se acquisti dei medicinali, verifica con un farmacista che siano adatti da assumere insieme agli altri tuoi medicinali.
Non conservare medicinali scaduti o indesiderati. Chiedi al tuo farmacista come smaltire i medicinali in modo sicuro nella tua zona.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Sito web Yellow Card.

Non sei sicuro di mescolare i medicinali?
Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.
Domande frequenti
What is the difference between meperidine and other strong opioid painkillers?
Meperidine is a strong opioid painkiller, similar to others in its class, but it has traditionally been used during childbirth because its effects are shorter-lasting compared to some other strong opioids. It works by acting on your nervous system and brain to decrease the amount of pain you feel.
How long do the effects of a meperidine injection last?
If you receive a meperidine injection, it can be repeated every few hours during labor if needed. For other types of pain, such as after surgery, the injection can be repeated every three to four hours. This indicates that its effects last for a few hours.
Are there any specific instructions for taking meperidine liquid medicine?
Yes, if you are prescribed meperidine oral liquid medicine, you should use a measuring cup or oral syringe to accurately measure the dose. This measured dose must then be mixed in half a glass of water before you swallow it. Swallowing the liquid undiluted can cause numbness in your mouth.
Why can't meperidine be used for a long time?
Meperidine tablets or liquid are not typically given for extended periods because repeated use over time can lead to your body becoming dependent on it. If you stop taking it after prolonged use, you could experience withdrawal symptoms like restlessness and irritability. This is generally not an issue if you receive only one or two doses during labor.
What should I do if I forget to take a dose of meperidine?
If you forget to take a dose of meperidine, you should take it as soon as you remember. After that, continue taking your subsequent doses every three to four hours from that point. It is important not to take two doses together to compensate for a missed dose.
Will meperidine affect my ability to drive?
Yes, meperidine is likely to affect your reactions and ability to drive. It is an offense to drive while your reactions are impaired. Even if you believe your driving ability is not impaired, it's advisable to carry evidence that the medicine has been prescribed for you, such as a prescription form or a patient information leaflet.
Is it safe to travel internationally with meperidine?
If you plan to travel abroad and need to take meperidine with you, it's recommended to carry a letter from your physician. This is because meperidine is classified as a 'controlled drug' and may be subject to certain restrictions in different countries.
Ulteriori letture e riferimenti
- FDA Drug Label, Demerol® 50 mg and 100 mg Tablets; Validus Pharmaceuticals LLC, DailyMed, National Institutes of Health, US National Library of Medicine. Dated March 2021.
- FDA Drug Label, Meperidine 50 mg/5 ml Oral Solution (50 mg and 100 mg Tablets); Boehringer Ingelheim, DailyMed, National Institutes of Health, US National Library of Medicine. Dated May 2006.
- FDA Drug Label, Meperidine 25 mg/ml, 50 mg/ml, 100 mg/ml Injection; Hikma Pharmaceuticals USA Inc., DailyMed, National Institutes of Health, US National Library of Medicine. Dated April 2022.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 26 ago 2027
27 Feb 2023 | Ultima versione
1 Mar 2017 | Pubblicato originariamente
Autore:
Michael Stewart, MRPharmS

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