Idrocortisone per il sostituto del cortisolo
Hydventia, Plenadren, Alkindi
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 19 Gen 2025
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Hydrocortisone belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Il tuo farmacista ti darà una 'Scheda di Trattamento con Steroidi' blu. Portala sempre con te.
If you need any medical treatment, make sure the person treating you knows that you are taking hydrocortisone. This is because your dose may need to be increased for a short while.
A colpo d'occhio
Hydrocortisone is a corticosteroid used as replacement treatment for conditions like Addison's disease.
It is available as tablets, soluble tablets, modified-release tablets and capsules, and granules.
Take immediate-release tablets after food, and some modified-release tablets 30 minutes before breakfast.
Tell your doctor and dentist you are taking hydrocortisone if you have an operation or dental treatment.
You will be given a Steroid Treatment Card to carry with you.
Contact your doctor if you become ill or are exposed to measles, shingles, or chickenpox.
Informazioni sull'idrocortisone
Tipo di medicinale | A corticosteroid medicine |
Utilizzato per | Cortisol replacement treatment in people with Addison's disease or following surgical removal of the adrenal glands |
Chiamato anche | Hydventia®, Plenadren® (modified-release tablets), Efmody® (modified-release capsules), Alkindi® (granules) |
Disponibile come | Tablets, soluble tablets, modified-release tablets and capsules, granules in capsules for opening |
Hydrocortisone belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid. It is used as a replacement treatment for people whose adrenal glands are not producing as much of the steroid hormones (such as cortisol) as they normally do. This can happen in a condition known as adrenal insufficiency, or malattia di Addison. It also happens in people who have had surgery to remove their adrenal glands and who therefore no longer make their own natural steroid hormones. These hormones are vital for your body and if you do not have enough of them, you can become very unwell.
Hydrocortisone is usually prescribed alongside another replacement medicine called fludrocortisone. Fludrocortisone is a substitute medicine for one of the other vital hormones that are no longer being made in people with adrenal insufficiency.
Before taking hydrocortisone tablets or capsules
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking hydrocortisone it is important that your doctor knows:
Se hai la pressione alta.
Se hai avuto un infarto o se hai altri problemi cardiaci.
Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.
If you (or a close family member) have either diabetes (diabetes mellitus) or an eye condition called glaucoma.
If you have any of the following conditions: an underactive thyroid gland, 'thinning' of the bones (osteoporosis), epilepsy, a condition causing muscle weakness (called myasthenia gravis), a stomach ulcer, or an inflammatory bowel disorder.
Se hai mai avuto un problema di salute mentale.
If you are pregnant or breastfeeding. (Oral steroids like hydrocortisone can be taken while you are expecting or breastfeeding; however, it is important that your doctor knows about the baby.)
If you have any kind of infection at the moment, or if you have ever had tuberculosis (TB).
If you have ever had an unwanted blood clot in an artery or a vein.
Se hai recentemente ricevuto, o stai per ricevere, qualsiasi vaccinazione.
Se stai assumendo altri medicinali, inclusi quelli disponibili per l'acquisto senza prescrizione, così come medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale, o se hai mai sviluppato dolori muscolari dopo aver assunto un medicinale steroideo.
How to take hydrocortisone tablets or capsules
Before starting the treatment, read the manufacturer's printed information leaflet from inside the pack and any additional information you are given by your doctor. These will give you more information about hydrocortisone and will also provide you with a full list of side-effects which you could experience from taking it.
Your doctor or pharmacist will tell you how many tablets to take and when to take them. This information will also be printed on the label of the packet of tablets to remind you about what was said to you. It is important that you take hydrocortisone exactly as your doctor tells you to. As a guide:
If you are taking immediate-release tablets (called simply 'Hydrocortisone tablets'), it is likely that you will be prescribed two or three doses to take each day. It is usual for your morning dose to be larger than the other doses. Take the tablets just after eating a meal, or alternatively with a snack.
If you have been prescribed a brand of tablet called Plenadren®, this is a tablet which releases hydrocortisone to your body throughout the day. It is usual to take one dose a day, 30 minutes before your breakfast. Swallow the tablet whole (this means do not break, crush, or chew it), with a drink of water. Do not drink grapefruit juice if you are taking Plenadren® because it will interfere with the way the tablets work.
If you (or your child) have been prescribed granules in capsules for opening (Alkindi®) follow the manufacturer's instructions closely. Do not swallow the capsule. Carefully open the capsule and place the granules either directly onto the tongue, onto a spoon or onto some soft food like yoghurt or apple sauce. Make sure the capsule is empty of granules. Have a drink of water or milk after swallowing the granules.
Try to take your doses at the same time of day each day, as this will help you to remember to take hydrocortisone regularly. If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Continue to take hydrocortisone tablets regularly each day - it is vital for your well-being. Hydrocortisone replacement treatment is almost always lifelong.
Ottenere il massimo dal tuo trattamento
You will be given a 'Steroid Treatment Card' which says that you are on steroids and contains some important advice for you. It is important that you read this card and carry it with you at all times. It also contains details about your dose, how long you have been taking hydrocortisone and who prescribed it for you. Please make sure that this information is kept up to date. If you are due to have an operation or dental treatment, or if you are having any treatment for an injury, please tell the person carrying out the treatment that you are taking hydrocortisone and show them your treatment card.
Cerca di mantenere i tuoi appuntamenti regolari con il tuo medico. Questo è per permettere al tuo medico di controllare i tuoi progressi. Il tuo medico vorrà che tu faccia esami di tanto in tanto per assicurarsi che tu rimanga libero da alcuni degli effetti collaterali indesiderati del trattamento.
It is important that if you become ill you make an appointment to see your doctor straightaway. Also, if you come into contact with anyone who has measles, shingles or chickenpox (or anyone who suspects they might have them), you should contact your doctor for advice as soon as possible.
Make sure you get your next supply of tablets well in advance so that you never run out. People with Addison's disease are entitled to free prescriptions.
Some vaccines are not suitable for you while you are being treated with hydrocortisone. If you need any immunisations, make sure you mention that you are taking hydrocortisone.
If you buy any medicines 'over the counter', please check with a pharmacist that they are suitable for you to take alongside hydrocortisone.
Il cortisone può causare problemi?
Along with its useful effects, hydrocortisone can cause unwanted side-effects which your doctor will discuss with you. The benefits of taking hydrocortisone usually outweigh the side-effects; however, they can sometimes be troublesome. Although not everyone experiences side-effects, and some will improve as your body adjusts to the new medicine, speak with your doctor or pharmacist if you become concerned about any of the following:
Common hydrocortisone side-effects | Cosa posso fare se sperimento questo? |
Ritenzione idrica che causa gonfiore a piedi e caviglie | Quando possibile, siediti con i piedi sollevati |
Tummy (abdominal) pain, indigestion, feeling sick (nausea) | Eat little and often. Stick to simple or bland foods. If you are sick and there is blood present, you must speak with your doctor straightaway |
Muscle weakness or feeling tired | Se ciò accade, non guidare e non utilizzare strumenti o macchinari finché non ti senti più sveglio |
Mood or behavioural changes, especially at the beginning of treatment | If you become confused or irritable, or start having worrying thoughts about harming yourself, speak with your doctor straightaway |
Difficulties sleeping, headache, increased weight, and irregular periods in women | Se uno di questi diventa problematico, parla con il tuo medico |
Increased risk of getting an infection | If you become ill, make an appointment to see your doctor straightaway |
Long-term treatment with hydrocortisone may cause other unwanted effects | Se hai sintomi che ti preoccupano, dovresti fissare un appuntamento con il tuo medico per un consiglio |
For more information about side-effects which are possible when a corticosteroid is taken long-term, please see the separate leaflet called Steroidi orali.
How to store hydrocortisone tablets or capsules
Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Informazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Sito web Yellow Card.

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Domande frequenti
What is the difference between immediate-release tablets and modified-release tablets like Plenadren®?
Immediate-release hydrocortisone tablets are typically taken two or three times a day, often with a larger dose in the morning, and should be taken just after eating or with a snack. Plenadren® is a modified-release tablet designed to release hydrocortisone throughout the day, so it is usually taken once daily, 30 minutes before breakfast, and must be swallowed whole.
Are there any specific foods or drinks I should avoid while taking hydrocortisone?
Yes, if you are taking Plenadren® (a modified-release tablet), you should not drink grapefruit juice. Grapefruit juice can interfere with how this specific form of hydrocortisone works in your body. For other forms of hydrocortisone, the article does not specify food or drink restrictions, but immediate-release tablets are advised to be taken just after eating a meal or with a snack.
If I am pregnant or breastfeeding, is it safe to take hydrocortisone?
Oral steroids like hydrocortisone can be taken while you are pregnant or breastfeeding. However, it is very important to inform your doctor about your pregnancy or if you are breastfeeding so they can ensure it's managed appropriately for both you and your baby.
What should I do if I think I've taken too much hydrocortisone?
You should never take more than your prescribed dose. If you suspect that you or someone else might have taken an overdose of hydrocortisone, you should immediately go to the accident and emergency department of your local hospital. Remember to take the medicine container with you, even if it is empty.
Can I stop taking hydrocortisone if I feel better?
No, it is vital to continue taking hydrocortisone tablets regularly each day as prescribed by your doctor. This replacement treatment is almost always lifelong for conditions like adrenal insufficiency, and stopping it can make you very unwell. Consult your doctor if you have any concerns or wish to discuss your treatment.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Plenadren® 5 mg and 20 mg modified-release tablets; Takeda UK Ltd, The electronic Medicines Compendium. Dated December 2023.
- Manufacturer' PIL, Alkindi® 1 mg granules in capsules for opening; Diurnal Limited, The electronic Medicines Compendium. Dated January 2024.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
Informazioni sull'autoreVisualizza il profilo completo

Michael Stewart, MRPharmS
Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista
BPharm (Hons), MRPharmS
Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.
Informazioni sul recensore

Sid Dajani
Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Articolo disponibile anche in Inglese, Tedesco, Spagnolo, Francese, Italiano, Portoghese, Hindi, Ebraico, Arabo, and Svedese.
Prossima revisione prevista: 19 Gen 2028
19 Gen 2025 | Ultima versione

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