Eplerenone tablets
Inspra
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 24 Feb 2023
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Take eplerenone tablets once a day.
Do not use salt substitutes while you are taking eplerenone.
Make sure your doctor knows about any other medicines you are taking alongside eplerenone.
In questo articolo:
About eplerenone
Tipo di medicinale | An aldosterone antagonist |
Utilizzato per | Insufficienza cardiaca |
Chiamato anche | Inspra® |
Disponibile come | Compresse |
Insufficienza cardiaca means that your heart is not functioning as well as it should. In a healthy heart, a set amount of blood enters the heart during each heartbeat and is pumped out again. If you have heart failure, your heart cannot cope with pumping the full amount of blood in each heartbeat.
If you have heart failure which affects the left ventricle of your heart (left-sided heart failure), it can cause you to be short of breath. It can also be associated with a cough. This is generally worse when you are active (for example, walking uphill) or when you are lying flat in bed.
Eplerenone is prescribed alongside other medicines to help prevent worsening of heart failure in people who have left-sided heart failure. It works by blocking the action of a substance in your body called aldosterone. High levels of aldosterone can cause changes that result in heart failure. By blocking aldosterone, eplerenone helps prevent heart failure from worsening.
Before taking eplerenone
Torna ai contenutiSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking eplerenone it is important that your doctor knows:
If you have any problems with the way your kidneys work, or if you have any problems with the way your liver works.
If you have been told you have high levels of potassium in your blood.
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How to take eplerenone
Torna ai contenutiBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about eplerenone, and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take eplerenone exactly as your doctor tells you to. You will be prescribed one tablet to take every day. There are two strengths of tablet - you will be prescribed the lower-strength (25 mg) tablet to begin with, but this will be increased to the 50 mg strength tablet within a few weeks.
Swallow the tablet whole with a drink of water. You can take eplerenone either with or without food.
Unless your doctor tells you otherwise, you can generally take eplerenone at a time of day you find easy to remember. It is best, however, to try to take the tablets at the same time of day each day, as this will help you to remember to take your doses regularly.
If you forget to take a dose, take one as soon as you remember, if this is during the same day as your dose was due. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses at the same time to make up for a missed dose.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by eplerenone and your doctor will want you to have a blood test from time to time to check the amount of potassium in your blood.
Try to avoid things with a high potassium content, such as 'salt substitutes'. This is so the level of potassium in your body does not become too high.
For most people with heart failure, regular exercise is advised. The healthier the heart, the better it will pump. The level of exercise recommended varies from person to person, so before you start to exercise, get the go-ahead from your doctor.
Your doctor may advise you to make some lifestyle changes, like losing weight if you are overweight, reducing the amount of alcohol you drink, and stopping smoking. Following this advice will help to improve the health of your heart.
If you buy any medicines 'over the counter', check with a pharmacist that they are suitable to take with your prescribed medicines. This is because some painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) may not be recommended for you.
If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
Treatment with eplerenone is usually long-term, so continue to take the tablets regularly until you are advised otherwise by your doctor.
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Can eplerenone cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with eplerenone. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Effetti collaterali comuni eplerenone side-effects (these affect fewer than 1 in 10 people) | Cosa posso fare se sperimento questo? |
Feeling dizzy or light-headed | If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing. Do not drive and do not use tools or machines while affected. If this continues, speak with your doctor |
Mal di testa | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, speak with your doctor |
Feeling sick (nausea) | Stick to simple foods - avoid fatty or spicy meals. If this continues, speak with your doctor |
Diarrea | Drink plenty of water to replace lost fluids. If this continues, speak with your doctor |
Costipazione | Eat a well-balanced diet and drink several glasses of water each day |
Cough, itchy skin rash, kidney problems, muscle spasms, sleeping problems, back pain | Se problematico, parla con il tuo medico |
Changes to blood tests (such as high blood potassium and high blood cholesterol) | Your doctor will check for this |
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.
How to store eplerenone
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
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Se si verificano effetti collaterali, è possibile segnalarli online tramite il sito web Yellow Card.
Video consigliati per Trattamento e prevenzione delle malattie cardiache

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Ulteriori letture e riferimenti
- Manufacturer's PIL, Inspra® 25 mg and 50 mg film-coated tablets; Upjohn UK Ltd, The electronic Medicines Compendium. Dated February 2021.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 23 Feb 2026
24 Feb 2023 | Ultima versione

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