Darbepoetin alfa

About darbepoetin alfa

Avere anemia means that you have either fewer red blood cells than normal, or less haemoglobin than normal in each red blood cell. Haemoglobin is a protein which carries oxygen from your lungs to the rest of your body and also carries the waste product carbon dioxide back to your lungs. As a result of having less haemoglobin than normal, there is less oxygen available to the cells of your body and this can make you feel tired, dizzy, and short of breath.

Persone con malattia renale cronica are particularly prone to anaemia. This is because the kidneys normally produce a hormone called erythropoietin which controls how many red blood cells your body makes. When your kidneys do not work as well as they should, your kidneys do not produce enough of this hormone. Darbepoetin alfa is similar to erythropoietin and works by encouraging your bone marrow to produce more red blood cells. It is given by an injection.

Some people having anti-cancer treatments also develop anaemia. This is because the medicines used for the treatment of the cancer can also stop the bone marrow from producing sufficient red blood cells. Here again, darbepoetin encourages the bone marrow to produce more red blood cells.

Before using darbepoetin alfa

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using darbepoetin alfa it is important that your doctor knows:

• Se sei incinta o stai allattando.

• Se hai problemi con il funzionamento del tuo fegato.

• If you take medicines to control your blood pressure.

• Se hai l'epilessia.

• If you are being treated for cancer.

• Se hai l'anemia falciforme.

• If you have any problems with your blood vessels, or if you have recently had a heart attack or stroke.

• If you have previously had a poor response to any medicines used to treat anaemia.

• Se hai mai avuto una reazione allergica a un medicinale.

• Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

How to use darbepoetin alfa

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about how to use darbepoetin alfa, and will provide you with a full list of the side-effects which you could experience from using it.

• Darbepoetin alfa is given by injection. It will be given during dialysis, or by a doctor or nurse, or alternatively, you could be trained how to give the injections to yourself. It is important that you give the injections exactly as your doctor tells you to. You will be told what dose is right for you and how often the injections should be given.

• If you have chronic kidney disease, darbepoetin alfa is usually given as a single injection under the surface of your skin either once a week, once every two weeks, or once a month.

• If you are receiving chemotherapy, it is usually given as a single injection under the surface of your skin either once a week or once every three weeks. Please carefully follow the directions your doctor gives to you and ask if you are unsure about anything.

• If you miss a dose for any reason, please contact your doctor or clinic to find out when the next injection should be given.

Ottenere il massimo dal tuo trattamento

• Make sure that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood tests to make sure that the amount of haemoglobin in your blood stays within a certain range. If your level were to become too high, it could put you at risk of serious heart or blood vessel problems (even a heart attack or stroke).

• It will be a few weeks before you notice the effect from the treatment. This is because it takes your body a few weeks to make more red blood cells.

Can darbepoetin alfa cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with darbepoetin alfa. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms which you think may be due to the injection, please speak with your doctor or pharmacist for further advice.

How to store darbepoetin alfa

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Store in a refrigerator (2°C-8°C). Do not freeze.

• You can take the injection out of the fridge and leave it at room temperature for approximately 30 minutes before you use it.

• Once the injection has been left at room temperature, it must be used within seven days or disposed of.
  

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