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Impianto di goserelin

Zoladex / Zoladex LA

Goserelin implants are injected under the surface of the skin on your stomach.

Each time you collect a prescription, check to make sure it looks the same as you have had before. There are two strengths of implant - Zoladex® 3.6 mg and Zoladex® LA 10.8 mg (long-acting). .

The most common side-effects are hot flushes, sweating, and reduced interest in sex.

A colpo d'occhio

  • Goserelin is a medicine given by implant to stop the body producing certain sex hormones.

  • It is used to treat prostate cancer in men and breast cancer in women.

  • It also treats endometriosis, uterine fibroids, and infertility in women.

  • You should tell your doctor if you have certain conditions like high blood pressure or diabetes.

  • Common side-effects include hot flushes, sweating, and headache in women.

  • If you develop a skin rash or breathing difficulties, contact your doctor immediately.

About goserelin

Tipo di medicinale

A gonadorelin analogue (also known as an LHRH analogue)

Utilizzato per

In women: endometriosis; uterine fibroids; breast cancer; to thin the lining of the womb (uterus) before an operation; as part of a treatment for infertility
In men
: prostate cancer

Chiamato anche

Zoladex®; Zoladex® LA

Disponibile come

Implant and long-acting implant

Goserelin works by acting on the pituitary gland in your brain to stop the production of some of the sex hormones which your body makes naturally. It is given for a number of different conditions. It is used to treat some cancers - cancro alla prostata in men, and cancro al seno in women. It is also given to women for some problems associated with the womb, and to help treat infertilità.

Although it is unclear exactly why prostate cancer or breast cancer develops, it is known that the sex hormones testosterone (in men) and oestrogen (in women) increase the growth of these cancers. Goserelin reduces the amount of these hormones, and this helps to stop the growth of the cancer cells.

In women, because it inhibits the production of female sex hormones, it is helpful in treating problems such as endometriosi e fibromi uterini. It is also given to prepare the womb before some surgical operations. Goserelin also encourages ovulation in women, and it is for this reason it is used in infertility treatments.

Goserelin is contained in a small pellet which is implanted (like an injection) under the surface of the skin on your stomach.

Before you have goserelin

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you are given goserelin it is important that your doctor knows:

  • If you have low moods or are depressed.

  • Se hai la pressione alta.

  • Se ti è stato detto che hai un battito cardiaco irregolare.

  • Se hai livelli elevati di zucchero nel sangue (diabete mellito).

  • If you have any vaginal bleeding for which you do not know the cause (that is, not your normal monthly period).

  • Se stai assumendo o utilizzando altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

  • Se hai mai avuto una reazione allergica a un medicinale.

How goserelin is given

  • Before you are given the implant, ask to read the printed information leaflet from the pack. The manufacturer's leaflet will give you information about the implant and will provide a full list of the side-effects which you may experience from it. If, as a result of reading the leaflet, you have any questions, please discuss them with your doctor/nurse before you have the implant.

  • The implant will be inserted for you by a person who has been specially trained. A very small pellet will be inserted just underneath the skin on your stomach.

  • Depending on the reason for your treatment, you may require further implants at 4-weekly or 12-weekly intervals. Remember to book your next appointment in plenty of time so that you receive the implant when it is due.

  • Try to keep your regular appointments with your doctor so that your progress can be monitored. If your doctor gives you a prescription so that you can collect the goserelin implant from the pharmacy, remember to take it with you for your appointment.

Ottenere il massimo dal tuo trattamento

  • Goserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.

  • Information for women: if you require contraception while you are on goserelin, use a barrier method such as a condom or cap (diaphragm). Do not use oral contraceptives ('the pill'). If you are using goserelin as a fertilisation treatment, you will already have had a test to show that you are not pregnant. You should not receive goserelin if you are pregnant, or think you might be pregnant.

  • Information for men: you may notice that your symptoms become worse when you first start treatment with goserelin and your doctor will give you some tablets to take during the first few weeks to help reduce this. Your symptoms should start to improve after a couple of weeks.

Can goserelin implants cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with goserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common

goserelin side-effects (these affect more than 1 in 10 people)


Cosa posso fare se sperimento questo?

Hot flushes, sweating (these may continue after stopping treatment with goserelin)

Take care not to become over-heated

Erectile dysfunction, reduced interest in sex

Parla con il tuo medico per consigli

Headache (in women)

Bevi molta acqua e chiedi al tuo farmacista di consigliarti un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico

Common

goserelin side-effects

(questi colpiscono meno di 1 persona su 10)

Cosa posso fare se sperimento questo?

Vaginal dryness or bleeding, acne (women), changes in breast size, depressed mood, tingling in the fingers or toes, skin rash, bone pain, reactions at the site of injection, decreased bone density, changes in blood pressure, weight changes, and an increased risk of heart attack (men)

Se sei preoccupato per uno di questi, parla con il tuo medico

Importante: if you develop a skin rash or have any difficulties with your breathing, you should contact your doctor for advice straightaway. These are rare but possibly serious symptoms, as they may be signs of an allergic reaction.

If you notice any other problems which you think may be caused by the implant, speak with your pharmacist or doctor for advice.

How to store goserelin

  • Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

  • Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali

Informazioni importanti su tutti i medicinali

Se acquisti dei medicinali, verifica con un farmacista che siano adatti da assumere insieme agli altri tuoi medicinali.

Se devi sottoporti a un'operazione o a un trattamento dentistico, informa la persona che esegue il trattamento sui medicinali che stai assumendo.

Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.

If you have any questions about your medicines, ask your pharmacist.

MHRA - Segnalazione di reazioni avverse

Segnala sospetti effetti collaterali di farmaci, vaccini, sigarette elettroniche, incidenti con dispositivi medici, prodotti difettosi o falsificati (falsi) all'Agenzia regolatoria dei medicinali e dei prodotti sanitari per garantire un uso sicuro ed efficace.

verificatore di sintomi

Non sei sicuro di mescolare i medicinali?

Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.

Domande frequenti

What is the difference between Zoladex and Zoladex LA?

The article lists 'Zoladex®' and 'Zoladex® LA' under the 'Also called' section and notes Goserelin is available as an 'Implant and long-acting implant'. This suggests Zoladex LA is simply the long-acting version of the Zoladex implant, likely referring to the 12-weekly interval instead of the usual 4-weekly one for the regular implant.

How long will I need to be on goserelin treatment?

The duration of goserelin treatment is not specified in the article, but it mentions that you may require further implants at 4-weekly or 12-weekly intervals, depending on the reason for your treatment. Your doctor will monitor your progress and advise on the total course of treatment.

Will goserelin interact with my other medications?

Yes, it's important for your doctor to know if you are taking any other medicines, including those bought without a prescription, as well as herbal and complementary medicines. This is so they can check for any potential interactions before you are given goserelin.

What should I do if I forget to get my next goserelin implant?

The article advises remembering to book your next appointment in plenty of time so that you receive the implant when it is due. If you miss an appointment or are concerned about when to get your next implant, you should contact your doctor's office for advice on rescheduling.

Can goserelin affect my mood or mental health?

Yes, goserelin can cause changes in mood. The article mentions that a depressed mood is a common side-effect, affecting fewer than 1 in 10 people. It also asks if you have low moods or are depressed as something important for your doctor to know before prescribing goserelin.

Ulteriori letture e riferimenti

Informazioni sull'autoreVisualizza il profilo completo

Immagine dell'autore

Michael Stewart, MRPharmS

Responsabile Revisione Foglietti Illustrativi – Contrattista, Farmacista

BPharm (Hons), MRPharmS

Michael è un farmacista comunitario che esercita nelle Midlands e nel South Yorkshire con oltre 20 anni di esperienza nel consigliare su farmaci e condizioni mediche. Ha una solida esperienza nella formazione sanitaria, avendo prodotto e tenuto corsi di formazione per team di farmacia e personale di strutture di assistenza residenziale, inclusi infermieri. Ha anche contribuito a consigli consultivi farmaceutici per la gestione di condizioni a bassa gravità nella comunità.

Informazioni sul recensore

Immagine dell'autore

Sid Dajani

Sultan Dajani si è laureato alla London School of Pharmacy nel 1994 ed è diventato il più giovane membro eletto del consiglio della Royal Pharmaceutical Society dalla sua fondazione nel 1842.

Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • Prossima revisione prevista: 17 Nov 2027
  • 18 maggio 2023 | Ultima versione

    Ultimo aggiornamento di

    Michael Stewart, MRPharmS

    Revisione paritaria di

    Sid Dajani
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