recombination signal binding protein for immunoglobulin kappa J region
Ultimo aggiornamento 8 Sept 2025
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Notch signaling controls how certain types of cells develop in the growing embryo, including those that form the bones, heart, muscles, nerves, and blood. Signaling through the Notch pathway stimulates the RBP-J protein to attach (bind) to specific regions of DNA and control the activity of genes that play a role in cellular development.
Normal function
L RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Notch signaling controls how certain types of cells develop in the growing embryo, including those that form the bones, heart, muscles, nerves, and blood. Signaling through the Notch pathway stimulates the RBP-J protein to attach (bind) to specific regions of DNA and control the activity of genes that play a role in cellular development.
Conditions referring to this gene or chromosome
Altri nomi
CBF-1
CBF1
H-2K binding factor-2
IGKJRB
IGKJRB1
RBP-J
RBP-J kappa
RBP-JK
RBPJK
RBPSUH
SUH
SUH_HUMAN
Related patient information and medicines
Patient information leaflet
Sindrome di Guillain-Barré
G... Guillain-Barré syndrome is an autoimmune disease. The immune system normally makes small proteins (antibodies) to attack bacteria, viruses, and other germs. For example, you may need help and support with feeding and breathing until the symptoms ease. Some specific treatments that may be given include one or more of the following:.
Patient information leaflet
Il sistema immunitario
This leaflet gives a brief overview of the sistema immunitario and how it works. A person with a weak immune system might have difficulty fighting off infections. In autoimmune diseases the body is unable to tell what is its own and what is foreign, so it attacks itself. Autoimmune diseases can attack any part of the body - eg, type 1 diabetes.
Patient information leaflet
Virus Mpox
Antibodies sono proteins made by our immune system during infection. Immunoglobulins Immunoglobulins are antibodies. These are proteins that are made by the body's immune system to fight infection. We can also make treatments for some diseases by getting these antibodies from a number of... Vaccinia immune globulin (VIG) is an immunoglobulin made.
Patient information leaflet
Test anticorpali e antigenici
Tests to det... What is the difference between antibodies and antigens. Antibodies are small proteins that circulate in the bloodstream. They are part of the body's defence (immune) system and are sometimes called immunoglobulins. They are made by a type of white blood cell (a B lymphocyte). Antibodies attach to proteins and other chemicals in the.
Patient information leaflet
Malattia di Bornholm
Bornholm disease is an illness which causes flu-like symptoms, together with pain in the chest or tummy (abdomen). Young babies are most at risk of serious complications. Babies may need preventative treatment (immunoglobulin) to help prevent complications. What is Bornholm disease. The recommended treatment is called immunoglobulin. This is given.
Patient information leaflet
Porpora trombocitopenica immune
These are less often used now than they used to be. Immunoglobulina endovenosa (IVIg) This is an injection of a protein into the bloodstream and has been shown to work well in about 8 in 10 children in increasing the number of platelets. It is not usually used as the first option because it involves an injection. Immunoglobulina Anti-D This is.
Ulteriori letture e riferimenti
- recombination signal binding protein for immunoglobulin kappa J region; MedlinePlus, National Library of Medicine.
- Castel D, Mourikis P, Bartels SJ, Brinkman AB, Tajbakhsh S, Stunnenberg HG. Dynamic binding of RBPJ is determined by Notch signaling status. Genes Dev. 2013 May 1;27(9):1059-71. doi: 10.1101/gad.211912.112.
- Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet. 2012 Aug 10;91(2):391-5. doi: 10.1016/j.ajhg.2012.07.005.
- Zanotti S, Canalis E. Notch signaling in skeletal health and disease. Eur J Endocrinol. 2013 May 8;168(6):R95-103. doi: 10.1530/EJE-13-0115. Print 2013 Jun.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.