Head and neck squamous cell carcinoma
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Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.
Descrizione
Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.
HNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.
HNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis.
Modelli di ereditarietà
The source lists the following possible inheritance patterns: Not inherited. More than one pattern can apply in different cases.
Related genes
Altri nomi
HNSCC
SCCHN
Squamous cell carcinoma of the head and neck
Related patient information and medicines
Patient information leaflet
Tipi di cancro della pelle
This leaflet gives a general overview about skin cancer and the different skin cancer types - melanoma and non-melanoma. Squamous cell carcinoma (SCC) - skin cancer which develops from keratinocytes. Those aged over 75 years are about five times... A BCC typically develops on a sun-exposed area of the skin such as the head and neck. However, one.
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Lupus discoide
Discoid lupus is a rare skin condition but it is very long-lasting. It is usually sensitive to sunlight and causes scarring when the les... Discoid lupus can be divided into two groups: Localised discoid lupus occurs when the head and neck only are affected. The risk is greater for children who develop discoid lupus. Skin cancers (basal cell.
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Cheratosi attinica
An actinic keratosis (also known as a solar keratosis) is the most common skin condition caused by sun damage. Actinic keratoses are usually rough, scaly patches on sun-exposed areas such as the head and face. In people who have between seven and eight actinic keratoses on their skin, there is about a 1 in 10 chance that one will turn into a form.
Patient information leaflet
Prevenzione del cancro della pelle
Alcuni tumori della pelle can be partly prevented by protecting yourself from the sun, not smoking, and general... This leaflet gives tips on how to prevent skin cancer. There are three basic types of skin cancer: basal cell carcinomas, squamous cell carcinomas, and melanoma. The information above mainly applies to the skin cancer types basal cell.
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Cancro della pelle non melanoma
Non-melanoma skin cancers are any tumori della pelle that are not melanoma. The term is used because melanoma is very different to other skin cancers so it's important to think of them as separate types of skin cancers. Basal cell carcinomas (BCCs) and carcinomi a cellule squamose (SCC) are the main types of non-melanoma skin cancers. Types of non-melanoma.
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Gonfiori e protuberanze al collo
Skin problems All sorts of lumps and bumps can come from the skin on your neck, including: Acne wit... Skin tags. Sebaceous cysts. Abscesses. Skin tumours, such as melanoma oppure squamous cell carcinoma. Developmental abnormalities A number of unusual lumps can occur that either people are born with (congenital) or which occurred as part of slightly.
Ulteriori letture e riferimenti
- Head and neck squamous cell carcinoma; MedlinePlus, National Library of Medicine.
- Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Trevino L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug 26;333(6046):1154-7. doi: 10.1126/science.1206923. Epub 2011 Jul 28.
- Lim AM, Do H, Young RJ, Wong SQ, Angel C, Collins M, Takano EA, Corry J, Wiesenfeld D, Kleid S, Sigston E, Lyons B, Fox SB, Rischin D, Dobrovic A, Solomon B. Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome. Int J Cancer. 2014 Aug 15;135(4):887-95. doi: 10.1002/ijc.28727. Epub 2014 Jan 30.
- Mountzios G, Rampias T, Psyrri A. The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact. Ann Oncol. 2014 Oct;25(10):1889-1900. doi: 10.1093/annonc/mdu143. Epub 2014 Apr 8.
- Rothenberg SM, Ellisen LW. The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Invest. 2012 Jun;122(6):1951-7. doi: 10.1172/jci59889.
- Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortes ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareno C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26;333(6046):1157-60. doi: 10.1126/science.1208130. Epub 2011 Jul 28.
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