The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
The RESCUE study is researching people who have had surgery for head and neck cancer that has either reappeared, didn't fully go away, or is a new cancer in the same area. The study aims to understand how successful this surgery is, looking at how long people live and their day-to-day abilities afterwards. It also involves a closer look at the cancer's genes for some patients. This genetic part helps researchers understand if previous radiation treatment or a person's unique genes play a role in why the cancer came back. The study hopes to improve future treatments for head and neck cancer.
A colpo d'occhio
Di cosa tratta questo studio?
The RESCUE study is looking into an important area of head and neck cancer care. Sometimes, head and neck cancer can come back, not fully go away after initial treatment, or a new cancer can develop in the same region. When this happens, doctors sometimes recommend 'salvage surgery' – an operation to remove the cancer again. This study wants to understand how effective this surgery is for patients.
Researchers will be looking at two main things. First, they want to see how people recover and their overall health after this type of surgery. This includes understanding how long patients live and how well they can do daily activities like eating and speaking. Second, for some patients who agree, the study will examine the cancer tissue at a very detailed level, looking at its genetic makeup. This is known as 'molecular analysis'.
By combining information about patient outcomes with detailed genetic insights, the RESCUE study aims to learn why some cancers return and others don't, especially after previous treatments like radiotherapy. The goal is to gather knowledge that could help doctors make better treatment decisions in the future and improve the lives of people facing recurrent head and neck cancer.
Punti chiave
- The RESCUE study aims to improve understanding of head and neck cancer that returns.
- It focuses on patients having additional surgery (salvage surgery) after previous treatment.
- Researchers will look at how well patients recover and their quality of life.
- For some, they'll also study the cancer's genes to see links with previous radiotherapy.
- Your medical records and existing tissue samples (if applicable) are used, not extra tests.
- Participation helps researchers find better treatments for future patients.
Chi può essere idoneo?
To be part of this study, you would need to be over 18 years old. You should have previously had head and neck cancer that was treated with radiotherapy (which might have also included chemotherapy).
The cancer being studied is a specific type called squamous cell carcinoma, which has either come back, wasn't fully removed, or is a new cancer in your mouth, throat, or voice box area.
There are also reasons why someone might not be able to join. For example, if your head and neck cancer is in certain areas like the nose or skin, or if it's a different type of cancer (not squamous cell carcinoma), you wouldn't be eligible. Also, if the cancer has spread to distant parts of your body or is too advanced for surgery, you wouldn't be able to participate.
Questo studio potrebbe fare al caso tuo?
Rispondi a queste domande rapide per vedere se potresti essere idoneo. Questo è solo una guida — il team di ricerca prende la decisione finale.
- Hai più di 18 anni?
- Have you had head and neck cancer (squamous cell carcinoma) treated with radiotherapy before?
- Has your head and neck cancer come back, not fully gone, or is it a new cancer in related areas?
- Is your cancer limited to the head and neck area (not spread far away)?
- Is your specific type of head and neck cancer not in your nose, skin, or a non-squamous cell type?
Cosa comporta la partecipazione?
If you decide to take part in the RESCUE study, your involvement would mainly revolve around the information gathered from your medical records related to your salvage surgery for head and neck cancer. This is because the study is looking at patient experiences and outcomes. If you consent to the 'molecular analysis' part, this would involve researchers studying a sample of your cancer tissue, likely taken during your surgery. There are no additional visits, medication, or specific procedures beyond your standard medical care for this study. The total duration of your participation would depend on how long the researchers track patient outcomes, but it wouldn't involve extra effort from you once your initial consent and data collection are done.
Rischi e benefici potenziali
Luoghi (9)
- University Hospitals Derby and BurtonCodice postale verificatoDerby, Regno Unito· Reclutamento
- NHS LothianCodice postale verificatoEdimburgo, Regno Unito· Reclutamento
- Western General, Greater Glasgow and ClydeCodice postale verificatoGlasgow, Regno Unito· Reclutamento
- Aintree HospitalCodice postale verificatoLiverpool, Regno Unito· Reclutamento
- Head and Neck Unit, Royal Marsden HospitalCodice postale verificatoLondra, Regno Unito· Reclutamento
- Northwick ParkCodice postale verificatoLondra, Regno Unito· Reclutamento
- Oxford University Hospital NHS Foundation TrustCodice postale verificatoOxford, Regno Unito· Reclutamento
- Poole Hospital, University Hospitals DorsetCodice postale verificatoPoole, United Kingdom· Reclutamento
- South Tyneside and Sunderland NHS Foundation TrustCodice postale verificatoSunderland, United Kingdom· Completato
Domande comuni
What kind of cancer is this study about?
It's about squamous cell carcinoma, a common type of head and neck cancer.
What does 'salvage surgery' mean?
It's surgery done when head and neck cancer has returned, not fully disappeared, or is a new cancer after previous treatment.
Will I have extra tests or appointments if I join?
No, this study uses information from your existing medical records and, if you agree, a tissue sample from your surgery. There are no extra tests or appointments.
What is 'molecular analysis'?
It's a detailed look at the cancer's genes to understand why it might have returned, especially after radiotherapy.
Will taking part affect my medical treatment?
No, your decision to join or not join will not affect the medical care you receive.
Come saperne di più
Andrew Williamson
Parla sempre con il tuo medico di base o specialista prima di decidere di partecipare a uno studio.
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