Compresse di Rilpivirina per l'HIV

About rilpivirine

Rilpivirine is an antiretroviral medicine. It is used for infezione da virus dell'immunodeficienza umana (HIV). It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Rilpivirine slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the virus from copying (replicating) itself.

Rilpivirine will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Before taking rilpivirine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking rilpivirine it is important that your doctor knows:

• Se sei incinta, stai cercando di avere un bambino o stai allattando.

• Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.

• Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

• Se hai mai avuto una reazione allergica a un medicinale.

How to take rilpivirine

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rilpivirine, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take rilpivirine exactly as your doctor tells you to. The usual dose is one 25 mg tablet daily. It is important that you take the tablets with a meal, as this will help your body to absorb the full dose. Please note - it is not sufficient to take the tablet with a protein-rich nutritional drink instead of a meal.

• Swallow the tablets whole with a drink of water. Do not crush, break or chew the tablets.

• Try to take your doses at the same time of day each day, as this will help you to remember to take rilpivirine regularly.

• If you forget to take a tablet at your usual time, you should take it (with a meal) as soon as you remember, providing it is within 12 hours of the time you should have taken the dose. If when you remember, it is more than 12 hours late then do not take the missed tablet, but do remember to take your next tablet on time. Do not take two doses together to make up for a missed dose.

Ottenere il massimo dal tuo trattamento

• Mantieni i tuoi appuntamenti regolari con il tuo medico in modo che i tuoi progressi possano essere monitorati. Avrai bisogno di fare esami del sangue regolari.

• It is important that you continue to take rilpivirine and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking rilpivirine, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Segui attentamente qualsiasi consiglio che il tuo medico ti dà riguardo ai cambiamenti dello stile di vita per ridurre il rischio di danni al cuore e ai vasi sanguigni. Questi possono includere smettere di fumare, mangiare in modo sano e fare esercizio fisico regolarmente.

• Anche se il trattamento con farmaci antiretrovirali può ridurre il rischio di trasmettere l'HIV ad altri attraverso il contatto sessuale, non lo elimina completamente. È importante che usi i preservativi.

• If you are trying for a baby or become pregnant whilst taking rilpivirine, let your doctor know straightaway. Rilpivirine may become less effective during pregnancy and your doctor might ask you to take a different medicine.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression, or any distressing thoughts about harming yourself, then you should speak with your doctor immediatamente.

• Alcune persone che hanno assunto farmaci antiretrovirali (soprattutto per un lungo periodo) hanno sviluppato una condizione chiamata osteonecrosi. Questa è una malattia ossea in cui il tessuto osseo muore a causa di una ridotta fornitura di sangue. Porta a dolori articolari e rigidità, e può causare difficoltà nei movimenti. Se noti uno di questi sintomi, parla con il tuo medico.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with rilpivirine and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly. In particular, do not take St John's wort. Also, some antacids can reduce the amount of rilpivirine your body absorbs. Because of this, it is recommended that you do not take indigestion remedies during the two hours before or during the four hours after you take rilpivirine.

• Alcune persone che assumono farmaci antiretrovirali sviluppano cambiamenti nel modo in cui il grasso corporeo è distribuito nel corpo. Questo può comportare cambiamenti nell'immagine corporea. Il tuo medico discuterà con te la possibilità di questo.

• Se devi sottoporti a un'operazione o a un trattamento dentistico, informa la persona che esegue il trattamento sui medicinali che stai assumendo.

• Treatment for HIV is usually lifelong. Continue to take rilpivirine regularly, even if you feel well. This is to keep your immune system healthy.

Can rilpivirine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rilpivirine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.

How to store rilpivirine

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali