Granisetron for nausea and vomiting

About granisetron

Granisetron is an anti-sickness medicine, also known as an antiemetic. It is a serotonin receptor antagonist. It is prescribed to stop you from feeling sick (nauseated). It works by blocking the effect of a naturally produced chemical in your body, called serotonin. Serotonin is also referred to as 5HT₃.

Chemotherapy, radiotherapy and surgery can all cause the release of an increased amount of serotonin in your body. There are tiny areas in your small intestine and brain, called 5HT₃ receptors. Serotonin acts on these receptors and causes you to feel sick. Granisetron works by blocking serotonin from acting on the receptors, and this stops you from feeling sick or being sick (vomiting).

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking granisetron it is important that your doctor knows:

• Se sei incinta o stai allattando.

• Se ti è stato detto che hai un battito cardiaco irregolare.

• Se hai problemi con il funzionamento del tuo fegato.

• Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.

• Se hai mai avuto una reazione allergica a un medicinale.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about granisetron, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• If you are being prescribed granisetron because you are due to have surgery, you will be given an injection of granisetron shortly before the operation. You could be given further doses by injection after the surgery if it is needed. A doctor or nurse will administer the injections to you.

• Se devi avere un chemioterapia o radioterapia treatment that could cause you to feel sick, your doctor will prescribe granisetron for you to have before the treatment:

  • If you are able to take tablets, you will be given one dose of tablets to take within the hour before your treatment. You will then be asked to continue to take granisetron tablets for a few days - it is usual to be prescribed 2 mg daily (as one or two doses) for up to seven days. Swallow the tablets whole with a drink of water. You can take granisetron either with or without food.

  • If you are not able to take tablets, you could be given a skin patch containing granisetron. The patch will be applied to your upper arm, or possibly your tummy (abdomen), 24-48 hours before your treatment is due to begin. Leave it in place during your treatment and for a further 24 hours after the treatment has finished before you remove it. You can wash and bathe as normal while you are wearing the patch, but you should not allow the patch to be in direct contact with bright sunlight or heat (such as an electric blanket or a hot water bottle). Even after you have removed the patch, the area where the patch was should be protected from bright sunlight for a further 10 days. When you remove the patch, fold it in half with the sticky sides together, and ask your pharmacist or clinic to dispose of it.

  • Granisetron can also be given by injection. If this is the treatment prescribed for you, a doctor or nurse will administer the injections to you.

• Anche se non hai voglia di mangiare o bere, cerca di sorseggiare acqua regolarmente per evitare di rimanere senza liquidi (disidratato). Inoltre, invece di cercare di mangiare tre pasti principali al giorno, prova a mangiare piccoli spuntini semplici ma nutrienti, ogni poche ore.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with granisetron. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Importante: in a very few people, medicines like granisetron can cause a problem called serotonin syndrome. Although this occurs only rarely, should you develop stiff or shaky muscles, a very high temperature (fever), a fast heartbeat, or become confused or agitated, you should call for medical assistance straightaway.

Se si verificano altri sintomi che ritieni possano essere dovuti al medicinale, parla con il tuo medico o farmacista per ulteriori consigli.

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.