Can I take Warfarin and Ibuprofen together?

Perché succede

This is a 'double whammy' effect. Warfarin works by slowing down the blood's ability to clot. Ibuprofen also thins the blood by affecting platelets, and it can irritate the lining of the stomach, making ulcers or bleeding more likely. Together, they make it much harder for your body to stop any bleeding that starts.

You should avoid taking ibuprofen (or other similar anti-inflammatories like aspirin or naproxen) while taking warfarin unless specifically told to do so by your doctor. For pain relief, paracetamol is usually a much safer choice. If you have already taken them together and notice signs of bleeding—such as dark, tarry stools, bruising easily, or a nosebleed that won't stop—seek medical advice immediately.

Combined use (Drug-Drug Interaction)

Do not take ibuprofen while taking warfarin. Ibuprofen significantly increases the risk of severe internal bleeding and can interfere with how warfarin works. Use paracetamol for pain relief instead.

Asma

Do not take ibuprofen if you have asthma, as it can trigger a life-threatening asthma attack or worsening of breathing difficulties in some people.

Gravidanza

Warfarin must not be taken during pregnancy as it can cause serious birth defects and fatal bleeding in the unborn baby. Use effective contraception while taking this medicine.

Alcol

Avoid binge drinking. Regular, moderate consumption is usually fine, but sudden changes in alcohol intake can affect how warfarin works and increase the risk of bleeding.

Foods high in vitamin K (e.g. spinach, kale, broccoli, Brussels sprouts)

You do not need to avoid these, but you must keep your intake consistent. Vitamin K helps blood clot, which works against warfarin. A sudden increase or decrease in these foods can change your INR levels.

Cranberry juice and cranberry products

Avoid or limit cranberry juice. It can increase the effect of warfarin, making you more likely to bleed.

Succo di pompelmo

It is best to avoid large amounts of grapefruit juice as it may increase the risk of bleeding, though the evidence is less consistent than with other foods.

Pomegranate juice

Avoid or limit pomegranate juice as it may increase the effect of warfarin and the risk of bleeding.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.