Can I take Pregabalin and Tramadol together?

Perché succede

Both drugs work by depressing the central nervous system (CNS), but in different ways. Tramadol is an opioid-like painkiller, and pregabalin is an anti-convulsant used for nerve pain. When used together, their sedative effects add up (an additive effect), making the impact on your brain and breathing much stronger than if you took either drug alone.

You should only take these two medicines together if they have been specifically prescribed by your doctor with full knowledge of your current medications. If you are prescribed both, your doctor should start you on the lowest possible doses and monitor you closely. Seek immediate medical help if you experience extreme sleepiness, difficulty waking up, or slow, shallow breathing. Avoid driving or operating machinery until you know how this combination affects you.

Respiratory depression and CNS depression

Taking these medicines together significantly increases the risk of dangerous breathing difficulties, severe drowsiness, and coma. Avoid alcohol and other sedatives while taking this combination.

Seizure disorders (Epilepsy)

This medicine can trigger seizures or fits, even in patients without a history of epilepsy. The risk is higher if you take certain antidepressants or have a known seizure disorder.

Gravidanza

Pregnancy must be avoided. Use of this medicine during the first trimester is linked to an increased risk of major birth defects in the baby. Effective contraception must be used during treatment.

Alcol

You must avoid drinking alcohol while taking these medicines. Both tramadol and pregabalin cause drowsiness and dizziness; alcohol significantly increases these effects. Combining alcohol with these medications can also lead to dangerous breathing problems (respiratory depression) and severe impairment of coordination.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.