Can I take Clarithromycin and Rosuvastatin together?

Perché succede

Clarithromycin blocks a specific protein (OATP1B1) that helps the liver take up rosuvastatin. It also interferes with how the body breaks down the medicine. This causes the statin to build up to potentially toxic levels in the bloodstream.

You should speak to your doctor before taking these together. They may suggest temporarily stopping rosuvastatin while you finish the course of clarithromycin, or they may prescribe a lower dose of the statin. If you are already taking both and experience unusual muscle pain or dark-coloured urine, stop taking the statin and contact your doctor immediately.

Drug-drug interaction (Myopathy/Rhabdomyolysis)

Do not take these medicines together. Clarithromycin significantly increases the levels of rosuvastatin in your blood, which can cause severe muscle breakdown (rhabdomyolysis) and kidney damage. Your doctor must pause the statin while you take the antibiotic.

Gravidanza

Do not take rosuvastatin if you are pregnant or planning to become pregnant. It can cause serious harm to an unborn baby. Use effective contraception while taking it and stop immediately if you think you are pregnant.

Heart Rhythm Disorders (Long QT)

Clarithromycin can affect your heart rhythm. Seek immediate medical help if you experience palpitations, severe dizziness, or fainting, especially if you have a history of heart problems or are taking other medicines that affect the heart.

Succo di pompelmo

While rosuvastatin is less affected by grapefruit juice than other statins (like simvastatin), drinking very large quantities (more than 1.2 litres daily) may increase the levels of the medicine in your blood, potentially increasing the risk of side effects. Moderate consumption is generally considered safe.

Alcol

You should avoid drinking large amounts of alcohol while taking rosuvastatin. Regular high alcohol intake increases the risk of liver problems and muscle side effects associated with this medication.

While there is no direct interaction, both clarithromycin and alcohol can cause side effects like nausea, dizziness, or stomach upset. It is generally best to avoid alcohol until you have finished your course and feel better.

Food (General)

Clarithromycin can be taken with or without food. However, if you find that the medicine settles heavily on your stomach or causes nausea, taking it with a meal or snack can help reduce these side effects.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.