Can I take Black cohosh and St John's wort together?

Perché succede

Both supplements are processed by the liver. St John's wort is a potent inducer of liver enzymes (specifically CYP3A4), which can speed up the breakdown of other substances. Furthermore, both herbs have been independently linked to rare cases of hepatotoxicity (liver damage), and taking them together may theoretically increase this risk.

You should consult your doctor or a pharmacist before taking these two supplements together. If you do use them, watch for signs of liver trouble, such as yellowing of the eyes or skin (jaundice), dark urine, severe stomach pain, or unusual tiredness. It is also important to tell your doctor if you are taking any other prescribed medications, as St John's wort interacts with many common drugs.

Gravidanza

Do not use black cohosh during pregnancy. It may stimulate uterine contractions, potentially increasing the risk of miscarriage or premature labour.

Malattia del fegato

Black cohosh has been linked to rare but serious cases of liver failure. You must stop taking it and see a doctor immediately if you develop yellowing of the skin or eyes, dark urine, or severe stomach pain.

Hormone-sensitive conditions (e.g. breast cancer)

Because black cohosh may act like the hormone oestrogen, you should not use it if you have a history of breast cancer, uterine cancer, or endometriosis without specialist medical supervision.

Hormonal contraception (Pill, implant, or patch)

St John's wort makes hormonal contraceptives less effective, which can lead to unplanned pregnancy. You must use an additional barrier method like condoms.

Prescription medications (Anticoagulants, Antidepressants, Epilepsy drugs)

St John's wort interacts with many life-saving medicines (like warfarin or ciclosporin) by speeding up how the body breaks them down, making them stop working. Never start it without a pharmacist checking your full medication list.

Alcol

Black cohosh has been linked to rare but serious cases of liver damage. Because alcohol also puts strain on the liver, it is advisable to limit or avoid alcohol consumption while taking this supplement to reduce the risk of liver toxicity. St John's wort can increase the sedative effects of alcohol, making you feel more drowsy or dizzy than usual. It is best to limit or avoid alcohol while taking this herbal remedy.

Caffeina

St John's wort may increase sensitivity to caffeine. This can lead to increased feelings of anxiety, jitteriness, or a racing heart.

Alimenti ricchi di Tiramina (ad esempio, formaggi stagionati, carni stagionate, prodotti fermentati)

Although the risk is lower than with older prescription antidepressants, St John's wort has some mild MAOI-like activity. Consuming very large amounts of tyramine-rich foods could potentially lead to a rise in blood pressure.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.