Can I take Amitriptyline and Zopiclone together?

You should only take these two medicines together if your doctor is specifically aware you are using both and has told you to do so.

Assumere amitriptilina e zopiclone together can make you feel extremely drowsy, dizzy, and confused.

Perché succede

Both medicines work by slowing down the activity in your central nervous system (your brain and nerves).

Amitriptyline is a a basso dosaggio with sedative properties, and zopiclone is a 'Z-drug' used for sleep.

When used together, their sedative effects add up (an additive effect), making the overall impact much stronger than taking either medicine alone.

You may be experiencing an interaction between amitriptyline and zopiclone if:

• You feel excessively sleepy, drowsy, or sedated during the day.

• You experience confusion, dizziness, or difficulty concentrating.

• You notice trouble with coordination or balance, increasing the risk of falls.

• You have memory problems or unusual behaviour.

• Breathing becomes slower or shallower than usual, especially at night.

• Symptoms appear shortly after taking both medicines together.
  

Se hai uno dei sintomi sopra elencati, dovresti:

• Speak to your GP or pharmacist for advice on safe use and dosing.

• Do not stop amitriptyline or zopiclone suddenly unless instructed by a healthcare professional.

• Seek urgent medical help if you experience severe drowsiness, breathing difficulties, or confusion.

• Avoid driving or operating machinery until you know how the combination affects you.

• Informa il tuo professionista sanitario su tutti gli altri medicinali e integratori che stai assumendo.

If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or drink any alcohol while using this combination. If you feel excessively sleepy the next day or have trouble breathing, contact your doctor immediately.

Pensieri suicidi e cambiamenti d'umore

L'amitriptilina può aumentare il rischio di pensieri suicidi o autolesionismo, in particolare all'inizio del trattamento o quando si cambiano le dosi. Cerca immediatamente assistenza medica se il tuo umore cambia o ti senti depresso.

Drowsiness and coordination

Both medicines cause significant drowsiness and impaired coordination. This effect is much stronger when they are taken together, significantly increasing the risk of falls and accidents. Do not drive or operate machinery until you know how they affect you.

Complex sleep behaviours

Zopiclone can cause you to get out of bed while not fully awake and do activities you do not remember (such as sleep-walking, driving, or preparing food). Stop taking it immediately if this happens.

Heart rhythm disorders

Amitriptyline can affect your heart rhythm. It must be used with extreme caution if you have a history of heart disease, particularly a recent heart attack or an irregular heartbeat (arrhythmia).

Alcol

You must avoid or strictly limit alcohol while taking these medicines. Both amitriptyline and zopiclone cause drowsiness and slow your reactions. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and an increased risk of falls or accidents.

Caffeine (Coffee, tea, energy drinks)

Caffeine is a stimulant that works against the sedative effects of zopiclone. Consuming caffeine, especially in the evening, can make zopiclone less effective at helping you sleep.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.