Can I take Amitriptyline and Sertraline together?

Perché succede

Both drugs increase a chemical in the brain called serotonin; too much of this can be dangerous. Additionally, sertraline slows down the liver's ability to break down amitriptyline, leading to higher levels of the drug in your bloodstream.

You should only take these two medicines together if specifically instructed and monitored by your doctor. Seek immediate medical help if you experience confusion, sweating, shivering, a very fast heartbeat, or muscle stiffness.

Sindrome serotoninergica

Taking these medicines together significantly increases the risk of serotonin syndrome, a potentially life-threatening condition. Seek urgent medical help if you experience high fever, agitation, confusion, or muscle twitching.

Suicidal thoughts

These medicines can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment or when the dose is changed. Patients under 25 are at higher risk.

Heart rhythm disorders

Amitriptyline can affect your heart rhythm (QT prolongation). It must be used with extreme caution if you have an existing heart condition or are taking other medicines that affect the heart.

Alcol

You should avoid or strictly limit alcohol while taking these medicines. Both amitriptyline and sertraline can cause drowsiness and dizziness; alcohol significantly increases these effects, which can impair your coordination and ability to drive or operate machinery safely.

Caffeina (Caffè, Tè, Bevande Energetiche)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen this effect or increase feelings of anxiety and restlessness, potentially counteracting the benefits of the medicine.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.