Can I take Alcohol and Paracetamol together?
Guida alle interazioni farmacologiche
Pubblicato originariamente 25 Gen 2026
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Drinking alcohol while taking paracetamol can increase the risk of serious liver damage. This is particularly dangerous for people who drink alcohol regularly or in large amounts (chronic heavy drinking), but it can also be a concern during a single episode of heavy drinking (binge drinking).
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If you are taking paracetamolo for pain, it is best to avoid alcohol entirely as combining them increases the risk of liver damage or even insufficienza epatica.
Never exceed the maximum dose of paracetamol (usually 4 grams or eight 500mg tablets in 24 hours), as alcohol makes even a small overdose much more dangerous.
If you drink more than 3 units of alcohol a day on a regular basis, you must speak to your doctor before taking paracetamol.
Perché succede
The liver breaks down paracetamol into a toxic byproduct. Normally, the liver uses a substance called glutathione to neutralise this toxin. Alcohol can deplete the liver's supply of glutathione and also cause the liver to produce more of the toxic byproduct, making it harder for the body to protect itself from liver damage.
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Torna ai contenutiYou may be experiencing an interaction between alcohol and paracetamol if:
You have nausea or vomiting after drinking alcohol and taking paracetamol.
You develop upper abdominal pain or tenderness.
You feel unusually tired, weak, or unwell.
You notice yellowing of the skin or eyes (jaundice).
You have dark urine or pale poo (stools).
Blood tests show raised liver enzymes.
Symptoms appear after drinking alcohol regularly or in large amounts while taking paracetamol.
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Cosa dovresti fare
Torna ai contenutiSe hai uno dei sintomi sopra elencati, dovresti:
Seek medical advice urgently, especially if you have abdominal pain or feel very unwell.
Call NHS 111 or attend A&E immediately if you have taken more than the recommended dose of paracetamol.
Do not take any more paracetamol or drink alcohol until you have been medically reviewed.
Tell the healthcare professional exactly how much paracetamol and alcohol you have had, and when.
Attend any blood tests arranged to check your liver function.
Precauzioni importanti
Torna ai contenutiLiver damage
Regularly drinking alcohol significantly increases the risk of severe liver damage if you take paracetamol. Do not exceed the maximum dose of paracetamol, and avoid heavy drinking while using it.
Combination products
Many cold and flu remedies also contain paracetamol. Taking more than one product containing paracetamol can lead to a fatal overdose. Always check the ingredients of other medicines.
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Avvertenza
Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.
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Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
25 Gen 2026 | Pubblicato originariamente

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