eukaryotic translation initiation factor 2 alpha kinase 4
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L EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Normal function
L EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Conditions referring to this gene or chromosome
Altri nomi
E2AK4_HUMAN
eukaryotic translation initiation factor 2-alpha kinase 4
GCN2
GCN2 eIF2alpha kinase
GCN2-like protein
general control nonderepressible 2
KIAA1338
PVOD2
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Ulteriori letture e riferimenti
- eukaryotic translation initiation factor 2 alpha kinase 4; MedlinePlus, National Library of Medicine.
- Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, Milenkovic D, Ferrara M, Bruhat A, Jousse C, Fafournoux P. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS J. 2009 Feb;276(3):707-18. doi: 10.1111/j.1742-4658.2008.06818.x. Epub 2008 Dec 19.
- Donnelly N, Gorman AM, Gupta S, Samali A. The eIF2alpha kinases: their structures and functions. Cell Mol Life Sci. 2013 Oct;70(19):3493-511. doi: 10.1007/s00018-012-1252-6. Epub 2013 Jan 26.
- Eyries M, Montani D, Girerd B, Perret C, Leroy A, Lonjou C, Chelghoum N, Coulet F, Bonnet D, Dorfmuller P, Fadel E, Sitbon O, Simonneau G, Tregouet DA, Humbert M, Soubrier F. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension. Nat Genet. 2014 Jan;46(1):65-9. doi: 10.1038/ng.2844. Epub 2013 Dec 1.
- Murguia JR, Serrano R. New functions of protein kinase Gcn2 in yeast and mammals. IUBMB Life. 2012 Dec;64(12):971-4. doi: 10.1002/iub.1090. Epub 2012 Nov 5.
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