anosmin 1
Ultimo aggiornamento 18 Ago 2020
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L ANOS1 gene, also known as KAL1, provides instructions for making a protein called anosmin-1. This protein is involved in development before birth. Anosmin-1 is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. Anosmin-1 is active in many parts of the developing embryo, including the respiratory tract, kidneys, digestive system, and certain regions of the brain.
Normal function
L ANOS1 gene, also known as KAL1, provides instructions for making a protein called anosmin-1. This protein is involved in development before birth. Anosmin-1 is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. Anosmin-1 is active in many parts of the developing embryo, including the respiratory tract, kidneys, digestive system, and certain regions of the brain.
Researchers are working to determine the functions of anosmin-1. They have discovered that, in the developing brain, this protein is involved in the movement (migration) of nerve cells and the outgrowth of axons, which are specialized extensions of nerve cells that transmit nerve impulses. The protein also plays a role in regulating contact between nerve cells (cell adhesion).
Anosmin-1 appears to help control the growth and migration of a group of nerve cells that are specialized to process the sense of smell (olfactory neurons). These nerve cells originate in the developing nose and then migrate together to a structure in the front of the brain called the olfactory bulb, which is critical for the perception of odors. Studies suggest that anosmin-1 is also involved in the migration of neurons that produce a hormone called gonadotropin-releasing hormone (GnRH). Like olfactory neurons, GnRH-producing neurons migrate from the developing nose to the front of the brain. GnRH controls the production of several hormones that direct sexual development before birth and during puberty. These hormones are important for the normal function of the ovaries in women and testes in men.
Conditions referring to this gene or chromosome
Altri nomi
adhesion molecule-like X-linked
ADMLX
anosmin-1
HHA
KAL
KAL1
KALIG-1
Kallmann syndrome 1 protein
Kallmann syndrome protein
KALM_HUMAN
KMS
WFDC19
Related patient information and medicines
Patient information leaflet
Viaggiare verso località remote
The risk of malaria can be reduced by taking tablets. Self-treatment is a last resort as it is very difficult for anyone to make treatment decisions about themselves. Reference book Pocket First Aid e Wilderness Medicine: Drs Jim Duff and Peter Gormly (2010). This is an excellent handbook covering what to do as a layperson in most medical.
Patient information leaflet
Trattamento del diabete di tipo 2
If any of the above risk factors apply to you: If you are not currently on glucose-lowering treatment, your doctor will usually recommend you start taking metformin first. As soon as you are settled on metformin (and don't have significant side-effects), they will add the SGLT-2 inhibitor. If you are already taking metformin, your doctor should.
Patient information leaflet
Bupropione per smettere di fumare
If you want to stop smoking, taking bupropion (trade name Zyban®) roughly doubles your chance of success. What is bupropion. Bupropion (Zyban®) è a medicine that was primo developed to treat depression. It was found that it helped smokers to stop smoking. It seems to relieve the withdrawal symptoms that you experience when you stop smoking (such.
Patient information leaflet
Emorragia subaracnoidea
A subarachnoid haemorrhage (SAH) is a form of stroke in which bleeding occurs into the fluid-filled space surrounding the brain (called the. It is usually caused by the rupture of a small berry-like swelling (called a berry aneurysm) on one of the arteries in the brain. SAH is a medical emergency. The risk of a further bleed is greatest during the.
Patient information leaflet
Emocromatosi
Emocromatosi è an inherited (genetic) disorder which causes the body to absorb too much iron from the diet. This excess iron causes damage to organs in which it builds up. The main treatment is the regular removal of blood which helps to remove the excess iron from the body. If treatment is started early, before complications occur, then the.
Patient information leaflet
Posso prendere Atorvastatina e integratori di fibre insieme?
Taking fibre supplements at the same time as atorvastatin can lower the amount of medicine your body absorbs. Nostro Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Avvertenza This information is for general educational purposes only and should not be.
Ulteriori letture e riferimenti
- anosmin 1; MedlinePlus, National Library of Medicine.
- Balasubramanian R, Crowley WF Jr. Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1334/
- Cariboni A, Pimpinelli F, Colamarino S, Zaninetti R, Piccolella M, Rumio C, Piva F, Rugarli EI, Maggi R. The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons. Hum Mol Genet. 2004 Nov 15;13(22):2781-91. doi: 10.1093/hmg/ddh309. Epub 2004 Oct 7.
- Choy C, Kim SH. Biological actions and interactions of anosmin-1. Front Horm Res. 2010;39:78-93. doi: 10.1159/000312695. Epub 2010 Apr 8.
- de Castro F, Esteban PF, Bribian A, Murcia-Belmonte V, Garcia-Gonzalez D, Clemente D. The adhesion molecule anosmin-1 in neurology: Kallmann syndrome and beyond. Adv Neurobiol. 2014;8:273-92. doi: 10.1007/978-1-4614-8090-7_12.
- Hardelin JP, Julliard AK, Moniot B, Soussi-Yanicostas N, Verney C, Schwanzel-Fukuda M, Ayer-Le Lievre C, Petit C. Anosmin-1 is a regionally restricted component of basement membranes and interstitial matrices during organogenesis: implications for the developmental anomalies of X chromosome-linked Kallmann syndrome. Dev Dyn. 1999 May;215(1):26-44. doi: 10.1002/(SICI)1097-0177(199905)215:13.0.CO;2-D.
- Hardelin JP, Levilliers J, del Castillo I, Cohen-Salmon M, Legouis R, Blanchard S, Compain S, Bouloux P, Kirk J, Moraine C, et al. X chromosome-linked Kallmann syndrome: stop mutations validate the candidate gene. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8190-4. doi: 10.1073/pnas.89.17.8190.
- Legouis R, Hardelin JP, Levilliers J, Claverie JM, Compain S, Wunderle V, Millasseau P, Le Paslier D, Cohen D, Caterina D, et al. The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell. 1991 Oct 18;67(2):423-35. doi: 10.1016/0092-8674(91)90193-3.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.