Colite ulcerosa
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Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterised by abnormal inflammation of the inner surface (epithelium) of the rectum and colon. The rectum and colon make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between the age of 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout a person's life, which causes recurring signs and symptoms.
Descrizione
Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterised by abnormal inflammation of the inner surface (epithelium) of the rectum and colon. The rectum and colon make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between the age of 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout a person's life, which causes recurring signs and symptoms.
The most common symptoms of ulcerative colitis are cramping abdominal pain and frequent diarrhea, often with blood, pus, or mucus in the stool. Other signs and symptoms include nausea, loss of appetite, bowel urgency, fatigue, and fevers. Chronic bleeding from the inflamed and ulcerated intestinal tissue can cause a shortage of red blood cells (anaemia) in some affected individuals. People with this disorder have difficulty absorbing enough fluids and nutrients from their diet and often experience weight loss. Affected children usually grow more slowly than normal. Less commonly, ulcerative colitis causes problems with the skin, joints, eyes, kidneys, or liver, which are most likely due to abnormal inflammation.
Toxic megacolon is a rare complication of ulcerative colitis that can be life-threatening. Toxic megacolon involves a widening (dilation) of the colon and an overwhelming inflammatory response. Ulcerative colitis also increases the risk of developing colon cancer, especially in people whose entire colon is inflamed and in those who have had ulcerative colitis for 8 years or more.
Ulcerative colitis is one common form of inflammatory bowel disease (IBD). Another type of IBD, Crohn's disease, also causes chronic inflammation of the intestines. Unlike ulcerative colitis, which affects only the inner surface of the large intestine, Crohn's disease can cause inflammation in any part of the digestive system, and the inflammation extends deeper into the intestinal tissue.
Modelli di ereditarietà
The source lists the following possible inheritance patterns: Pattern unknown. More than one pattern can apply in different cases.
Related genes
Altri nomi
Colitis gravis
Idiopathic proctocolitis
Inflammatory bowel disease, ulcerative colitis type
UC
Related patient information and medicines
Patient information leaflet
Colite ulcerosa
Ulcerative colitis is a disease where inflammation develops in the colon and the rectum (the large intestine). The most common symptom when the disease flares up is diarrhoea mixed with blood. Ulcerative colitis is a disease of the colon and the rectum (the large intestine). Ulcers that occur in ulcerative colitis develop in the large intestine.
Medicine leaflet
Compresse di beclometasone per colite ulcerosa
Beclometasone belongs to a class of medicines known as corticosteroids (m... About beclometasone tablets for colite ulcerosa Type of medicine A corticosteroid, also commonly called an oral steroid Used for Colite ulcerosa (in adults) Also called Beclomethasone (in US); Clipper® Available as Modified-release tablets (made to pass through your.
Medicine leaflet
Olsalazina per la colite ulcerosa
About olsalazine Type of medicine Aminosalicylate Used for Colite ulcerosa in adults and in children aged over 12 years Available as Capsules and tablets Ulcerative colitis causes inflammation of the large intestine. This can lead to damage to the lining of your intestine (ulceration) and bleeding, and causes symptoms of tummy (abdominal) pain.
Patient information leaflet
Sanguinamento rettale
See the separ... Colite ulcerosa and other forms of colitis Ulcerative colitis (UC) is a disease where inflammation develops in the colon and rectum. A common symptom when the disease flares up is diarrhoea mixed with blood. The blood comes from ulcers that develop on the lining of the inflamed gut. There are other rare causes of inflammation.
Patient information leaflet
Malattia infiammatoria intestinale
Inflammatory Bowel Disease (IBD) is a term used to descr... Ulcerative colitis only affects the intestinal wall of the colon and rectum, whereas Crohn's disease can affect any part of the gut. Surgery Ulcerative colitis solo affects the colon and rectum so an operation per remove the large bowel (total colectomy) will cure the condition. Ulcerative.
Patient information leaflet
Steroidi
Steroid medicines are used for many different medical conditions. Colite ulcerosa . Arthritis. These should only ever be started by a specialist eye doctor (ophthalmologist) who will usually have used a machine called a slit lamp to look into the bac... Rectal foam or suppositories to treat colite ulcerosa (proctitis) or for Crohn's disease.
Ulteriori letture e riferimenti
- Colite ulcerosa; MedlinePlus, National Library of Medicine.
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- Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011 Nov 3;365(18):1713-25. doi: 10.1056/NEJMra1102942. No abstract available.
- Di Sabatino A, Biancheri P, Rovedatti L, Macdonald TT, Corazza GR. Recent advances in understanding ulcerative colitis. Intern Emerg Med. 2012 Apr;7(2):103-11. doi: 10.1007/s11739-011-0719-z. Epub 2011 Nov 9.
- Fairbrass KM, Costantino SJ, Gracie DJ, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020 Dec;5(12):1053-1062. doi: 10.1016/S2468-1253(20)30300-9. Epub 2020 Oct 2.
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- Shim JO, Seo JK. Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations. J Hum Genet. 2014 Jun;59(6):337-41. doi: 10.1038/jhg.2014.32. Epub 2014 May 1.
- UK IBD Genetics Consortium; Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG; Wellcome Trust Case Control Consortium 2; Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, Spencer CC, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet. 2009 Dec;41(12):1330-4. doi: 10.1038/ng.483. Epub 2009 Nov 15.
- Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007 Jul 26;448(7152):427-34. doi: 10.1038/nature06005.
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