Personalized Anti-Inflammatory Fibres in Ulcerative Colitis

This study is looking for people who have been diagnosed with ulcerative colitis and currently have some active inflammation, even if they aren't experiencing many symptoms. You might be eligible if a specific test for inflammation in your stool shows active disease, or if your doctor has assessed your symptoms as active.

To join, you need to be at least 14 years old and weigh more than 40kg. It's important that your ulcerative colitis medication has been stable for at least three months before the study starts. This means no big changes to your treatment plan, although minor adjustments (like for weight changes) are usually fine.

However, you wouldn't be able to join if you have other bowel conditions like Crohn's disease, or if you have any blockages or serious problems with your digestive system. People with other significant health issues, such as severe heart, kidney, or lung disease, uncontrolled diabetes, or a severe ongoing infection, would also not be eligible.

If you decide to take part, you'll be asked to add a specific fibre supplement (either acacia gum, microcrystalline cellulose, or a placebo) to your daily diet for six weeks. This will be alongside your usual diet and medications. You'll need to visit the clinic three times in total: once at the beginning of the study, another visit after three weeks, and a final visit at the end of the six weeks.

During these clinic visits, you'll provide small samples of your stool and blood. You'll also be asked to complete some questionnaires about your health and how you're feeling. The total duration of your active participation in the study will be six weeks.