Compresse di Leflunomide per l'artrite

About leflunomide

Arthritis means inflammation of joints. Artrite reumatoide (RA) is a common form of arthritis. It is thought to be an autoimmune disease. The immune system normally makes small proteins (antibodies) to attack bacteria, viruses and other germs. In people with autoimmune diseases, the immune system makes antibodies against tissues of the body. In people with RA, antibodies are formed against the tissues that surround the joints. This causes inflammation, pain, and swelling around the affected joints. Over time, it causes damage. Medicines called disease-modifying antirheumatic drugs (DMARDs) are prescribed to suppress the inflammation.

Artrite psoriasica is a particular type of arthritis that develops in some people who also have a skin condition called psoriasis.

Leflunomide is a DMARD. It eases pain and stiffness associated with both of the conditions mentioned above, and it also reduces the damaging effect of the disease on joints. It is thought to work by blocking the way inflammation develops in joints.

Before taking leflunomide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking leflunomide it is important that your doctor knows:

• Se sei incinta, stai cercando di avere un bambino o stai allattando.

• Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.

• If you currently have an infection, or if you have ever had tuberculosis (TB).

• If you have been told by a doctor that you have low numbers of proteins in your blood.

• If you know you have a blood or bone marrow disorder.

• If you have a problem which affects your immune system, such as AIDS.

• Se hai mai avuto una reazione allergica a un medicinale.

• Se stai assumendo altri medicinali. Questo include qualsiasi medicinale disponibile per l'acquisto senza prescrizione, così come i medicinali a base di erbe e complementari.

How to take leflunomide

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about leflunomide and how to take it, and it will also provide you with a full list of the side-effects which you could experience

• If you have recently taken another DMARD, your doctor will want to make sure that all of this medicine has gone from your bloodstream before you start taking leflunomide. This is called a washout procedure. It is important that you follow any directions that you are given to do this.

• Take leflunomide exactly as your doctor tells you to. It is taken once a day. Your doctor will prescribe a high-strength (100 mg) tablet for the first three days. After this, the strength of your tablets will be reduced to 10 mg or 20 mg, and you will stay on this lower dose.

• Swallow the tablet with a drink of water. You can take leflunomide either with or without food. Swallow the tablet whole - do not chew or break it.

• Try to take leflunomide at the same time of day each day, as this will help you to remember to take it regularly, every day. If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses at the same time to make up for a missed dose.

Ottenere il massimo dal tuo trattamento

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have some blood tests before and during the treatment.

• Leflunomide may have no immediate effect on pain or inflammation. It can take several weeks before you notice any effect, and several months before you notice the full benefit. It is, however, important that you keep taking it as prescribed, even if it does not seem to be working at first.

• Your doctor will recommend that you do not drink alcohol while you are on leflunomide. This is because it can increase the risk of side-effects, such as liver problems.

• This medicine can harm an unborn baby:
  

  • If you are femminile, you must not get pregnant while you are taking leflunomide and for at least two years afterwards. Make sure you have discussed with your doctor what contraception is suitable for you and your partner. If you wish to have a baby after finishing treatment, you should discuss this with your doctor, as the medicine continues in your bloodstream for up to two years.

  • If you are maschio you must not father a child while you are taking leflunomide and for at least three months afterwards. Ask your doctor about suitable contraception. If you wish to become a father, you should discuss this with your doctor. It is important that it is confirmed that leflunomide has been sufficiently removed from your body before you father a child.

• Your doctor will discuss with you the possibility of unwanted side-effects, such as that you could become more susceptible to infections. Also, that there is a slightly increased risk of cancer associated with this medicine. If you have any concerns about your general health, discuss these with your doctor straightaway.

• While you are taking leflunomide, do not have any immunisations (vaccinations) without talking to your doctor first. Leflunomide lowers your body's resistance and there is a chance that you may get an infection from the vaccine. Also, some vaccines may be less effective.

• Before you have any kind of medical treatment, tell the doctor, dentist or surgeon that you are taking leflunomide. People taking leflunomide may be more likely to have problems with wound-healing after surgery.

• Treatment with leflunomide is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise.

Can leflunomide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with leflunomide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.

How to store leflunomide

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali