Can I take Lion's mane and Royal sun together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Both Lion's Mane (Hericium erinaceus) and Royal Sun (Agaricus blazei) may have mild blood-thinning effects and can lower blood sugar levels. Taking them together might increase the risk of bruising or bleeding, and could potentially cause your blood sugar to drop lower than expected.
Why this happens
Both fungi contain compounds that may interfere with blood clotting (anti-platelet activity) and improve insulin sensitivity. When combined, these effects can be additive, meaning they reinforce each other.
What you should do
This combination is usually fine for healthy individuals, but you should use caution if you are already taking blood-thinning medications (like aspirin or warfarin) or diabetes medication. Monitor your blood sugar levels if you are diabetic, and watch for signs of easy bruising or prolonged bleeding from small cuts. If you have a scheduled surgery, stop taking both supplements at least two times weeks beforehand.
Important precautions
Surgery
Stop taking these supplements at least 2 weeks before scheduled surgery as they may increase the risk of bleeding and interfere with blood sugar control during and after the procedure.
Bleeding disorders
These supplements may slow blood clotting and increase the risk of bruising or bleeding, especially if you are already taking anticoagulant or antiplatelet medications.
Diabetes
These mushrooms can lower blood sugar levels. Monitor your blood glucose closely if you take insulin or oral diabetes medications, as a dose adjustment may be necessary to prevent hypoglycaemia.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Lion's Mane and Royal Sun are processed by the liver; combining them with alcohol may increase the strain on your liver and potentially lead to liver damage. Additionally, alcohol can interfere with the immune-modulating effects of these medicinal mushrooms.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Warfarin and Ibuprofen together?
Taking ibuprofen while on warfarin significantly increases your risk of serious bleeding, particularly in the stomach or gut. This combination can cause internal bleeding that may be difficult to stop.

Drug interactions checker
Can I take Magnesium and Wegovy flextouch together?
There is no known direct interaction between magnesium supplements and Wegovy (semaglutide). However, both can affect your digestive system. Wegovy slows down how quickly your stomach empties, which could theoretically change how quickly your body absorbs magnesium, though this is rarely a clinical concern. Additionally, both can cause side effects like nausea or changes in bowel habits (magnesium often softens stools, while Wegovy can cause constipation or diarrhoea).
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Trazodone together?
- Can I take Amlodipine and Cod liver oil together?
- Can I take Aspirin and Methotrexate together?
- Can I take Atorvastatin and Ezetimibe together?
- Can I take Atorvastatin and Reishi together?
- Can I take Atorvastatin and Sertraline together?
- Can I take Bactrim and Venlafaxine together?
- Can I take Clopidogrel and Fenofibrate together?
- Can I take Esomeprazole and Fexofenadine together?
- Can I take Fluanxol and Venlafaxine together?
- Can I take Losartan and Vitamin B12 together?
- Can I take Magnesium and St John's wort together?
- Can I take Paracetamol and Quinine together?
- Can I take Sertraline and Alcohol together?
- Can I take Shiitake and Turkey tail together?
- Can I take Simvastatin and Vitamin B12 together?
- Can I take St John's wort and Vitamin B2 together?
- Can I take Vitamin B complex and Vitamin C together?
- Can I take Warfarin and Ibuprofen together?