Can I take Fexofenadine and Pregabalin together?

Why this happens

This is an 'additive' effect. While fexofenadine is a non-drowsy antihistamine, it can still cause mild sleepiness in some people. Pregabalin commonly affects the central nervous system. When combined, their individual effects on your alertness can add together.

What you should do

It is generally safe to take these together, but you should be cautious when you first start the combination. See how they affect you before driving or using machinery. If you feel very drowsy or dizzy, speak to your pharmacist or doctor.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Pregnancy

Pregabalin must not be used during pregnancy unless specifically advised by a specialist, as it has been linked to an increased risk of major birth defects. Effective contraception must be used during treatment.

History of substance misuse

Pregabalin carries a significant risk of dependence and addiction. It is a controlled drug because it can be misused or lead to withdrawal symptoms if stopped suddenly.

Respiratory depression

Pregabalin can cause severe breathing problems, especially if you already have lung disease or if you take it with other medicines that cause drowsiness or contain opioids.

Indigestion remedies (antacids)

Do not take indigestion remedies containing aluminium or magnesium within 2 hours of taking fexofenadine. These can lower the amount of medicine your body absorbs.

Food and drink warnings

Alcohol

While fexofenadine is a non-drowsy antihistamine, it is best to avoid or strictly limit alcohol while taking it. Combining the two can increase the risk of side effects like dizziness or sleepiness, and may affect your ability to perform tasks safely.

It is best to avoid or strictly limit alcohol when taking pregabalin. Both alcohol and pregabalin affect the central nervous system; combining them increases the risk of severe drowsiness, dizziness, and breathing difficulties. This can also increase the risk of falls.

Fruit juices (Grapefruit, Orange, Apple)

Drinking fruit juices, particularly grapefruit, orange, or apple juice, can significantly reduce the amount of fexofenadine absorbed by your body. This makes the medicine less effective. It is best to take fexofenadine with water and avoid drinking these juices for at least 2 hours before or after taking your dose.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.