Can I take Chaga and Cordyceps together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking chaga and cordyceps together may increase the risk of bruising or bleeding. Both supplements can also lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both chaga and cordyceps have 'anti-platelet' effects, meaning they slow down blood clotting. When used together, this effect is additive. Additionally, both fungi can mimic or enhance the effects of insulin, leading to a combined lowering of blood glucose.
What you should do
It is generally safe for healthy individuals to take these together in moderate amounts, but you should use caution. If you are scheduled for surgery, stop taking both at least two weeks beforehand. If you take medication for diabetes or blood-thinning drugs (like warfarin or aspirin), speak to your doctor before combining these supplements.
Important precautions
Kidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
Chaga may significantly lower blood sugar levels, increasing the risk of hypoglycaemia (dangerously low blood sugar) if you are taking insulin or other diabetes medications.
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
These mushrooms can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Both mushrooms have significant anti-platelet effects and can increase the risk of bruising and bleeding; they must be stopped at least 2 weeks before any planned surgery.
Food and drink warnings
Alcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Caffeine
Cordyceps may have mild stimulant properties and can interact with adenosine receptors. Combining it with caffeine (coffee, tea, energy drinks) may increase heart rate, jitteriness, or palpitations in sensitive individuals.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Flecainide and Wegovy together?
Wegovy (semaglutide) can slow down how quickly your stomach empties. This might change how your body absorbs flecainide, which is a medicine that needs to be kept at very specific levels in your blood to work safely and effectively. Additionally, both medications can occasionally affect your heart rhythm or heart rate.

Drug interactions checker
Can I take Sertraline and Fluoxetine together?
Taking sertraline and fluoxetine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens because both medicines work by increasing the level of a chemical called serotonin in your brain. If levels get too high, it can cause symptoms like shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, fluoxetine can slow down how your body breaks down sertraline, leading to a build-up of the drug in your system and increasing the risk of side effects.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amlodipine and Citalopram together?
- Can I take Aspirin and Evolocumab together?
- Can I take Atorvastatin and Colecalciferol together?
- Can I take Atorvastatin and Paracetamol together?
- Can I take Bisoprolol and Rybelsus (semaglutide) together?
- Can I take Clopidogrel and Gabapentin together?
- Can I take Cod liver oil and Garlic supplements together?
- Can I take Esomeprazole and Indapamide together?
- Can I take Esomeprazole and Sertraline together?
- Can I take Fluanxol and Iron supplements together?
- Can I take Glucosamine and Vitamin D together?
- Can I take Levothyroxine and Omeprazole together?
- Can I take Losartan and Vitamin B12 together?
- Can I take Magnesium and Warfarin together?
- Can I take Naproxen and Uribel together?
- Can I take Pregabalin and Tizanidine together?
- Can I take Reishi and Turkey tail together?
- Can I take Shiitake and Turkey tail together?
- Can I take Simvastatin and Vitamin B12 together?