Can I take Amlodipine and Lansoprazole together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelinesEst. 2 min reading time

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There is no known significant interaction between amlodipine and lansoprazole. These two medicines are commonly prescribed together and are generally considered safe to take at the same time.

Why this happens

Amlodipine (a blood pressure medicine) and lansoprazole (a stomach acid reducer) are processed by different pathways in the body and do not interfere with how the other works.

What you should do

You can continue to take both medicines as prescribed by your doctor. You do not need to change the timing of your doses or take any special precautions regarding this specific combination.

Important precautions

Liver disease

Amlodipine is broken down by the liver; if your liver is not working fully, the medicine can build up to toxic levels. Your doctor must monitor you closely and may need to use a much lower starting dose.

Severe diarrhoea

Lansoprazole can increase the risk of serious bacterial bowel infections (such as Campylobacter or C. difficile). If you develop severe or persistent watery diarrhoea, seek medical advice immediately and do not use anti-diarrhoeal medicines.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swelling. Avoid drinking large amounts of grapefruit juice.

Alcohol

While alcohol does not directly interact with amlodipine, both can lower your blood pressure. Drinking alcohol while taking this medicine may make you feel dizzy, lightheaded, or sleepy. It is best to keep alcohol intake to a minimum.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.

25 Jan 2026 | Originally published

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