Can I take Amitriptyline and Fexofenadine together?

Perché succede

Both amitriptyline and fexofenadine have 'anticholinergic' properties (though fexofenadine's effect is very weak). When combined, these effects can add up. Additionally, both can cause drowsiness, which may be more noticeable when they are taken at the same time.

It is generally safe to take these together, but you should be aware of increased side effects. If you feel very sleepy or dizzy, do not drive or operate machinery. If you find the dry mouth or constipation bothersome, speak to your pharmacist or doctor. Taking fexofenadine in the morning and amitriptyline at night may help reduce daytime drowsiness.

Suicidal thoughts and behaviour

Amitriptyline can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment or when the dose is changed. Patients and carers should monitor for any sudden changes in mood or behaviour.

Heart rhythm disorders (Long QT syndrome)

Amitriptyline can affect your heart rhythm. You must inform your doctor if you have a history of heart problems or are taking other medicines that affect the heart, as this can lead to a serious condition called an arrhythmia.

Indigestion remedies (Antacids)

Do not take indigestion remedies containing aluminium or magnesium within two hours of taking fexofenadine. These can significantly reduce the amount of medicine your body absorbs, making it less effective.

Alcol

Bere alcolici mentre si assume amitriptilina può far sentire molto assonnati e instabili sulle gambe. È meglio evitare l'alcol, soprattutto quando si inizia il trattamento o se la dose viene aumentata.

Fruit juices (Grapefruit, Orange, Apple)

Drinking large amounts of grapefruit, orange, or apple juice can reduce the amount of fexofenadine your body absorbs, making the medicine less effective. It is best to drink water when taking your tablet and avoid these juices for a few hours before and after taking your dose.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.