troponin T2, cardiac type
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L TNNT2 gene provides instructions for making a protein called cardiac troponin T, which is found solely in the heart (cardiac) muscle. Cardiac troponin T is one of three proteins that make up the troponin protein complex in cardiac muscle cells. The troponin complex is part of a structure called the sarcomere, which is the basic unit of muscle contraction. Sarcomeres are made up of thick and thin filaments. The overlapping thick and thin filaments attach (bind) to each other and release, which allows the filaments to move relative to one another so that muscles can contract. The troponin complex, along with calcium, helps regulate contraction of cardiac muscle.
Normal function
L TNNT2 gene provides instructions for making a protein called cardiac troponin T, which is found solely in the heart (cardiac) muscle. Cardiac troponin T is one of three proteins that make up the troponin protein complex in cardiac muscle cells. The troponin complex is part of a structure called the sarcomere, which is the basic unit of muscle contraction. Sarcomeres are made up of thick and thin filaments. The overlapping thick and thin filaments attach (bind) to each other and release, which allows the filaments to move relative to one another so that muscles can contract. The troponin complex, along with calcium, helps regulate contraction of cardiac muscle.
For the heart to beat normally, cardiac muscle must contract and relax in a coordinated way. Cardiac troponin T helps coordinate contraction of the heart muscle. When calcium levels are low, the troponin complex binds to the thin filament in sarcomeres, which blocks the interaction between the thick and thin filaments that is needed for muscle contraction. An increase in calcium levels causes structural changes in the troponin complex, which allows the thick and thin filaments to interact, leading to contraction of the heart muscle.
Conditions referring to this gene or chromosome
Altri nomi
cardiac muscle troponin T
cTnT
LVNC6
RCM3
TNNT2_HUMAN
TnTC
troponin T type 2 (cardiac)
troponin T, cardiac muscle
troponin T2, cardiac
Related patient information and medicines
Patient information leaflet
Enzimi cardiaci
Enzimi cardiaci sono substances released by the heart muscle when it is injured - for example, during a heart attack or a severe case of angina. ...enzymes are also sometimes called cardiac biomarkersThe cardiac enzyme levels that are tested are called cardiac troponins. Normal (skeletal) muscle also produces troponins ma troponins T and I are.
Patient information leaflet
Attacco di cuore
There are typical changes to... However, it is possible to have a heart attack without having these ECG changes. Blood tests. A blood test that measures a chemical called troponin is the usual test that confirms a attacco di cuore. An angiography of the coronary arteries may also be performed to find the blockage in the artery. Other tests may be done.
Patient information leaflet
Dolore toracico
Based on what they find, he or she may advise you... Investigations for chest pain can include: An ECG (electrocardiogram or 'heart tracing') There are often typical changes to the normal pattern of the 'heart tracing' (electrocardiogram, or ECG) in a heart attack. Blood tests A blood test that measures a chemical called troponin is the usual test.
Patient information leaflet
Posso assumere Biotina e Collagene insieme?
If you are due to have a blood test, tell your doctor or the lab staff that you are taking a biotin supplement. Important precautions Blood test interference Biotin can significantly interfere with laboratory blood tests, including funzione tiroidea e heart attack markers (troponin), leading to dangerously incorrect results. You must stop taking.
Patient information leaflet
Insufficienza respiratoria
They may help to work out the cause and also to detect any factors that may be worsening the respiratory failure, such as a low blood haemoglobin level (anaemia). Troponin blood tests : these are used to determine if there has been recent heart injury - for example, a heart attack which may have caused the respiratory failure. Thyroid function.
Patient information leaflet
Posso prendere Atorvastatina e Biotina insieme?
Muscle pain or weakness - atorvastatin Contact your doctor immediately if you ... In rare cases, this can lead to serious kidney problems. Laboratory blood tests Biotin can significantly interfere with certain lab tests, including heart attack markers (troponin) and thyroid tests, leading to incorrect results. Stop taking biotin at least 72 hours.
Ulteriori letture e riferimenti
- troponin T2, cardiac type; MedlinePlus, National Library of Medicine.
- Bashyam MD, Savithri GR, Kumar MS, Narasimhan C, Nallari P. Molecular genetics of familial hypertrophic cardiomyopathy (FHC). J Hum Genet. 2003;48(2):55-64. doi: 10.1007/s100380300007.
- Gomes AV, Barnes JA, Harada K, Potter JD. Role of troponin T in disease. Mol Cell Biochem. 2004 Aug;263(1-2):115-29. doi: 10.1023/B:MCBI.0000041853.20588.a0.
- Hershberger RE, Pinto JR, Parks SB, Kushner JD, Li D, Ludwigsen S, Cowan J, Morales A, Parvatiyar MS, Potter JD. Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. Circ Cardiovasc Genet. 2009 Aug;2(4):306-13. doi: 10.1161/CIRCGENETICS.108.846733. Epub 2009 May 15.
- Keren A, Syrris P, McKenna WJ. Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression. Nat Clin Pract Cardiovasc Med. 2008 Mar;5(3):158-68. doi: 10.1038/ncpcardio1110. Epub 2008 Jan 29.
- Marston SB. How do mutations in contractile proteins cause the primary familial cardiomyopathies? J Cardiovasc Transl Res. 2011 Jun;4(3):245-55. doi: 10.1007/s12265-011-9266-2. Epub 2011 Mar 22.
- Otten E, Lekanne Dit Deprez RH, Weiss MM, van Slegtenhorst M, Joosten M, van der Smagt JJ, de Jonge N, Kerstjens-Frederikse WS, Roofthooft MT, Balk AH, van den Berg MP, Ruiter JS, van Tintelen JP. Recurrent and founder mutations in the Netherlands: mutation p.K217del in troponin T2, causing dilated cardiomyopathy. Neth Heart J. 2010 Oct;18(10):478-85. doi: 10.1007/BF03091819.
- Rodriguez JE, McCudden CR, Willis MS. Familial hypertrophic cardiomyopathy: basic concepts and future molecular diagnostics. Clin Biochem. 2009 Jun;42(9):755-65. doi: 10.1016/j.clinbiochem.2009.01.020. Epub 2009 Feb 9.
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