transcription factor AP-2 alpha
Ultimo aggiornamento 29 Set 2025
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L TFAP2A gene provides instructions for making a protein called transcription factor AP-2 alpha (AP-2α). As its name suggests, this protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Transcription factor AP-2α is one of a group of related proteins called AP-2 transcription factors. These proteins regulate genes that help control cell division and the self-destruction (apoptosis) of cells that are no longer needed.
Normal function
L TFAP2A gene provides instructions for making a protein called transcription factor AP-2 alpha (AP-2α). As its name suggests, this protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Transcription factor AP-2α is one of a group of related proteins called AP-2 transcription factors. These proteins regulate genes that help control cell division and the self-destruction (apoptosis) of cells that are no longer needed.
Transcription factor AP-2α is involved in development before birth. In particular, this protein is active in the neural crest, which is a group of cells in the early embryo that give rise to many tissues and organs. Among the embryonic structures formed from neural crest cells are the branchial arches, which develop into the bones and other tissues of the head and neck. The TFAP2A gene appears to be especially important for the development of tissues derived from the first and second branchial arches.
Conditions referring to this gene or chromosome
Altri nomi
activating enhancer-binding protein 2-alpha
activator protein 2
AP-2
AP-2 transcription factor
AP-2alpha
AP2-alpha
AP2A_HUMAN
AP2TF
BOFS
TFAP2
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
transcription factor AP-2-alpha
Related patient information and medicines
Patient information leaflet
Sindrome delle gambe senza riposo
Also after a time on dopamine agonists, symptoms can suddenly become much worse. If this is the case, you will need to stop or change your medication. Alpha-2-delta ligands This is another group of recommended medicines (although they do not have a licence for this condition). The two possible options are gabapentin and pregabalin. These are less.
Patient information leaflet
Posso prendere Apixaban e Atorvastatina insieme?
C'è no significant interaction between apixaban and atorvastatin. Using other medicines Taking multiple medi... Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about.
Patient information leaflet
Posso prendere Apixaban ed Empagliflozin insieme?
C'è no known direct interaction between apixaban and empagliflozin. Perché succede Apixaban (a blood thinner) and empagliflozin (a diabetes medication) are processed by different pathways in the body. Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, e supplements are safe to take.
Patient information leaflet
Posso prendere Apixaban e Metformina insieme?
Perché succede Apixaban è a blood thinner (anticoagulant) and metformin è a medicine for type 2 diabetes. They work in completely different ways in the body and are processed by different organs and enzym... Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, e supplements are safe to.
Patient information leaflet
Posso prendere Alogliptin e Apixaban insieme?
Non ci sono no known significant interactions between alogliptin and apixaban. Perché succede Alogliptin (a diabetes medication) and apixaban (a blood thinner) are processed by different pathways in the body. Alogliptin is primarily excreted unchanged by the kidneys, while apixaban is processed by specific liver enzymes (CYP3A4) and a transport.
Patient information leaflet
Cancro ai testicoli
Testicular cancer is a cancer that arises from a testicle (testis). Around half of all cases occur in men aged under 35 but testicular cancer rarely occurs before puberty. Another useful test i... The tumour markers commonly tested for are alpha-fetoprotein (AFP), beta human chorionic gonadotrophin (beta-hCG), lactic dehydrogenase (LDH) and.
Ulteriori letture e riferimenti
- transcription factor AP-2 alpha; MedlinePlus, National Library of Medicine.
- de Croze N, Maczkowiak F, Monsoro-Burq AH. Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):155-60. doi: 10.1073/pnas.1010740107. Epub 2010 Dec 15.
- Developmental Biology (sixth edition, 2000): The Neural Crest
- Haldeman-Englert CR, Lin AE, Milunsky JM. Branchiooculofacial Syndrome. 2011 May 31 [updated 2025 Aug 14]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK55063/
- Hilger-Eversheim K, Moser M, Schorle H, Buettner R. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene. 2000 Dec 30;260(1-2):1-12. doi: 10.1016/s0378-1119(00)00454-6.
- Milunsky JM, Maher TA, Zhao G, Roberts AE, Stalker HJ, Zori RT, Burch MN, Clemens M, Mulliken JB, Smith R, Lin AE. TFAP2A mutations result in branchio-oculo-facial syndrome. Am J Hum Genet. 2008 May;82(5):1171-7. doi: 10.1016/j.ajhg.2008.03.005.
- Wang WD, Melville DB, Montero-Balaguer M, Hatzopoulos AK, Knapik EW. Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Dev Biol. 2011 Dec 1;360(1):173-85. doi: 10.1016/j.ydbio.2011.09.019. Epub 2011 Sep 22.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.