platelet derived growth factor subunit B
Ultimo aggiornamento 18 Ago 2020
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L PDGFB gene provides instructions for making one version (isoform) of the platelet derived growth factor (PDGF) protein. This protein is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), and movement. The PDGFB gene provides instructions for a precursor protein that must be processed to be able to perform its function. Before processing, the precursor PDGFB protein attaches (binds) to another PDGFB protein or a similar protein called the PDGFA precursor protein, forming a structure known as a dimer. Once the dimer is formed, the precursor proteins are processed by being cut at specific locations, which forms the functional (active) PDGF proteins, called PDGF-BB and PDGF-AB.
Normal function
L PDGFB gene provides instructions for making one version (isoform) of the platelet derived growth factor (PDGF) protein. This protein is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), and movement. The PDGFB gene provides instructions for a precursor protein that must be processed to be able to perform its function. Before processing, the precursor PDGFB protein attaches (binds) to another PDGFB protein or a similar protein called the PDGFA precursor protein, forming a structure known as a dimer. Once the dimer is formed, the precursor proteins are processed by being cut at specific locations, which forms the functional (active) PDGF proteins, called PDGF-BB and PDGF-AB.
The active PDGF-BB or PDGF-AB protein binds to a PDGF receptor, which initiates cellular signaling. PDGF signaling activates many pathways important in cell proliferation, differentiation, and movement.
Conditions referring to this gene or chromosome
Altri nomi
becaplermin
c-sis
FLJ12858
PDGF subunit B
PDGF, B chain
PDGF-2
PDGF2
platelet-derived growth factor 2
platelet-derived growth factor beta polypeptide
platelet-derived growth factor subunit B
platelet-derived growth factor, B chain
SIS
SSV
Related patient information and medicines
Patient information leaflet
Policitemia rubra vera
Polycythaemia rubra vera (PRV) is a myeloproliferative disorder, which means the bone marrow makes too many blood cells. It is also sometimes just called polycythaemia (PV). There is an abnormally high number of red blood cells in your blood. Various factors help to maintain this balance. For example, certain hormones in the bloodstream and.
Patient information leaflet
Trombofilia
When a blood vessel is injured, the clotting process is triggered. This is called the clotting cascade. It is a chain ... The clotting cascade makes the blood solidify into a clot, which sticks to the injured part of the blood vessel. Small particles in the blood, called platelets, also help to form the clot. There are also natural chemicals in.
Patient information leaflet
Emofilia
Emofilia is a rare bleeding disorder that affects your ability to make a clot. The blood contains substances called clotting factors that work with platelets to form a clot. When you injure yourself the clot stops you bleeding. Haemophilia is a condition where there is a deficiency of clotting factors, so people with this condition usually have.
Patient information leaflet
Test di coagulazione del sangue
Test di coagulazione del sangue are used to diagnose and assess bleeding problems and to monitor people who take warfarin or other anticoagulant medicines. You may be advised to have blood clotting tests: If you have a suspected bleeding disorder. For example, if you bleed a lot after cuts, or if you bruise easily. If you have certain liver diseases that can.
Patient information leaflet
Leucemia linfoblastica acuta
Acute lymphoblastic leukaemia (ALL) is a condition where the bone marrow makes large numbers of abnormal immature lymphocytes. What is acute lymphoblastic leukaemia. Acute lymphoblastic leukaemia (ALL) is a condition where the bone marrow makes large numbers of abnormal immature lymphocytes. The immature cells are called lymphoblasts. There are.
Patient information leaflet
Leucemia mieloide cronica
Many blast cells spill out into the bloodstre... In this phase there are more than 30% blast cells in the blood and bone marrow. Very rarely, CML develops into a condition called myelofibrosis. This means that the bone marrow can no longer make red cells, white cells or platelets because it is replaced by scar tissue (fibrosis). How is chronic.
Ulteriori letture e riferimenti
- platelet derived growth factor subunit B; MedlinePlus, National Library of Medicine.
- Greco A, Fusetti L, Villa R, Sozzi G, Minoletti F, Mauri P, Pierotti MA. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene. 1998 Sep 10;17(10):1313-9. doi: 10.1038/sj.onc.1202051.
- Heldin CH, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998 Aug 19;1378(1):F79-113. doi: 10.1016/s0304-419x(98)00015-8.
- Shimizu A, O'Brien KP, Sjoblom T, Pietras K, Buchdunger E, Collins VP, Heldin CH, Dumanski JP, Ostman A. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 1999 Aug 1;59(15):3719-23.
- Simon MP, Navarro M, Roux D, Pouyssegur J. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP). Oncogene. 2001 May 24;20(23):2965-75. doi: 10.1038/sj.onc.1204426.
- Simon MP, Pedeutour F, Sirvent N, Grosgeorge J, Minoletti F, Coindre JM, Terrier-Lacombe MJ, Mandahl N, Craver RD, Blin N, Sozzi G, Turc-Carel C, O'Brien KP, Kedra D, Fransson I, Guilbaud C, Dumanski JP. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet. 1997 Jan;15(1):95-8. doi: 10.1038/ng0197-95.
- Sirvent N, Maire G, Pedeutour F. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer. 2003 May;37(1):1-19. doi: 10.1002/gcc.10202.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.